KSEP may refer to:

• KSEP-LP, a low-power radio station (99.9 FM) licensed to Brookings, Oregon, United States
• Stephenville Clark Regional Airport in Stephenville, Texas (ICAO: KSEP)

• Trouble In Mind (Jodie Marie album)
• Trouble in Mind (TV series)
• Trouble in Paradise (1950 film)
• Trouble in Paradise (1989 TV film)
• Trouble in Paradise (Anri album)
• Trouble in Store (1934 film)
• Trouble in the Air
• Trouble in the Works
• Trouble In The Works
• Trouble in Twin Town
• Trouble Is a Woman
• Trouble Is My Middle Name
• Trouble (Lost Frequencies song)
• Troublemake
• Trouble Maker (album)
• Trouble Maker (car)
• Trouble Maker discography
• Trouble-Maker (film)
• Trouble Makers
• Trouble Makers (1917 film)
• Troublemakers (2015 film)
• Troublemakers (film)
• Troublemaker: Surviving Hollywood and Scientology
• Trouble (Mark Chesnutt song)
• Trouble (Matt Terry album)