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词条 Kv channel interacting protein
释义

  1. References

Kv channel interacting proteins are members of a family of voltage-gated potassium (Kv) channel-interacting proteins (KCNIPs, also frequently called "KChIP"), which belong to the recoverin branch of the EF-hand superfamily.[1] Members of the KCNIP family are small calcium binding proteins. They all have EF-hand-like domains, and differ from each other in the N-terminus. They are integral subunit components of native Kv4 channel complexes. They may regulate A-type currents, and hence neuronal excitability, in response to changes in intracellular calcium. Alternative splicing results in multiple transcript variant encoding different isoforms.[2]

Members of this family include:

  • KCNIP1, a protein that in humans is encoded by the KCNIP1 gene.[3][2]
  • KCNIP2, a protein that in humans is encoded by the KCNIP2 gene.[3][2]
  • KCNIP3, more commonly known as Calsenilin, a protein that in humans is encoded by the KCNIP3 gene.[4][5][2]
  • KCNIP4, a protein that in humans is encoded by the KCNIP4 gene.[6][7][2]

References

1. ^{{cite journal | author = Burgoyne RD| title = Neuronal calcium sensor proteins: generating diversity in neuronal Ca2+ signalling| journal = Nat. Rev. Neurosci. | volume = 8 | issue = 3 |pages = 182–193 | year = 2007 | pmid = 17311005 | pmc = 1887812 | doi = 10.1038/nrn2093 }}
2. ^1 2 3 4 {{cite web | title = Entrez Gene: KCNIP1 Kv channel interacting protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=30820| accessdate = }}
3. ^1 {{cite journal |vauthors=An WF, Bowlby MR, Betty M, Cao J, Ling HP, Mendoza G, Hinson JW, Mattsson KI, Strassle BW, Trimmer JS, Rhodes KJ | title = Modulation of A-type potassium channels by a family of calcium sensors | journal = Nature | volume = 403 | issue = 6769 | pages = 553–556 |date=Feb 2000 | pmid = 10676964 | pmc = | doi = 10.1038/35000592 }}
4. ^{{cite journal | vauthors = Buxbaum JD, Choi EK, Luo Y, Lilliehook C, Crowley AC, Merriam DE, Wasco W | title = Calsenilin: a calcium-binding protein that interacts with the presenilins and regulates the levels of a presenilin fragment | journal = Nat Med | volume = 4 | issue = 10 | pages = 1177–81 | date = October 1998 | pmid = 9771752 | pmc = | doi = 10.1038/2673 }}
5. ^{{cite journal | vauthors = Carrión AM, Link WA, Ledo F, Mellström B, Naranjo JR | title = DREAM is a Ca2+-regulated transcriptional repressor | journal = Nature | volume = 398 | issue = 6722 | pages = 80–4 | date = March 1999 | pmid = 10078534 | pmc = | doi = 10.1038/18044 }}
6. ^{{cite journal |vauthors=Holmqvist MH, Cao J, Hernandez-Pineda R, Jacobson MD, Carroll KI, Sung MA, Betty M, Ge P, Gilbride KJ, Brown ME, Jurman ME, Lawson D, Silos-Santiago I, Xie Y, Covarrubias M, Rhodes KJ, Distefano PS, An WF | title = Elimination of fast inactivation in Kv4 A-type potassium channels by an auxiliary subunit domain | journal = Proc Natl Acad Sci U S A | volume = 99 | issue = 2 | pages = 1035–40 |date=Jan 2002 | pmid = 11805342 | pmc = 117799 | doi = 10.1073/pnas.022509299 }}
7. ^{{cite journal |vauthors=Morohashi Y, Hatano N, Ohya S, Takikawa R, Watabiki T, Takasugi N, Imaizumi Y, Tomita T, Iwatsubo T | title = Molecular cloning and characterization of CALP/KChIP4, a novel EF-hand protein interacting with presenilin 2 and voltage-gated potassium channel subunit Kv4 | journal = J Biol Chem | volume = 277 | issue = 17 | pages = 14965–75 |date=Apr 2002 | pmid = 11847232 | pmc = | doi = 10.1074/jbc.M200897200 }}
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1 : EF-hand-containing proteins
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