| 词条 | Lara Mahal |
| 释义 |
| name = | native_name = | native_name_lang = | image = | image_size = | caption = | birth_date = | birth_place = | death_date = | death_place = | death_cause = | citizenship = | nationality = | fields = | workplaces = {{plainlist|
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}} | known_for = | awards = | spouse = | children = }} Dr. Lara K. Mahal is a Professor of Chemistry and Biochemistry at New York University.[1] She is notable both for her pioneering work establishing lectin microarrays as a new technology for glycomics,[2][3] her work on miRNA regulation of glycosylation [4][5][6][7] and her graduate work with Professor Carolyn R. Bertozzi on unnatural carbohydrate incorporation.[8] Work in her laboratory focuses on understanding the role of carbohydrates in signaling and on using systems-based approaches to decode the role of glycosylation in cell differentiation and pathogenesis.[9] AcademiaProfessor Mahal received her B.A. in Chemistry at the University of California, Santa Cruz in 1995. As an undergraduate, she worked on organic free radical chemistry in the laboratory of Professor Rebecca Braslau. In 1995, Professor Mahal joined the newly formed laboratory of Professor Bertozzi at the University of California, Berkeley where she worked on the incorporation of unnatural functionalized sialic acid derivatives onto the surface of cells. For this landmark work, Professor Mahal was awarded and American Chemical Society Medicinal Chemistry Pre-doctoral Fellowship. After graduating in 2001, Professor Mahal did postdoctoral research on neuronal exocytosis in the laboratory of Professor Jim Rothman at Memorial Sloan-Kettering Cancer Research Center. During this time Professor Mahal was a Jane Coffins Child Cancer Research Fellow. In 2003, Professor Mahal joined the faculty of the University of Texas at Austin as an Assistant Professor of Chemistry and Biochemistry. Tenured in 2009, she then joined the faculty of New York University as an Associate Professor of Chemistry in the Biomedical Chemistry Institute. She was promoted to Professor in 2016. Professor Mahal has received several major awards, including the Beckman Young Investigators Award (2004),[10] an NSF Career Award (2007), the Sloan Foundation Fellowship (2008), the 2008 NIH Director's New Innovator Award[11] and the Horace S. Isbell Award in Carbohydrate Chemistry (2017).[12] References1. ^http://chemistry.fas.nyu.edu/page/people 2. ^Pilobello, K.T.; Slawek, D.; Mahal, L.K. A ratiometric lectin microarray approach to analysis of the dynamic mammalian glycome, Proc. Natl. Acad. Sci., USA, 2007, 104, 10534-10539. 3. ^Krishnamoorthy L.; Mahal L.K. Glycomic analysis: an array of technologies. ACS Chem Biol. 2009, 4, 715-732. 4. ^Agrawal, P.; Kurcon, T.; Pilobello, K.T.; Rakus, J.F.; Koppolu, S.; Liu, Z.; Batista, B.S.; Eng, W.S., Hsu, K.-L.; Liang, Y.; Mahal, L.K. Mapping posttranscriptional regulation of the human glycome uncovers microRNA defining the glycocode. Proc. Natl. Acad. Sci., USA, 2014, 111, 4338-43. doi: 10.1073/pnas.1321524111 5. ^Kasper, B.T.; Koppolu, S.; Mahal, L.K. Insights into MiRNA Regulation of the Human Glycome. Biochem. Biophys. Res. Commun. 2014, 445, 774-9. doi: 10.1016/j.bbrc.2014.01.034. 6. ^Kurcon, T.; Liu, Z.; Paradkar, A.V.; Vaiana, C.A.; Koppolu, S.; Agrawal, P.; Mahal, L.K. miRNA proxy approach reveals hidden functions of glycosylation. Proc. Natl. Acad. Sci., USA, 2015, 112, 7327-32. doi: 10.1073/pnas.1502076112. 7. ^Vaiana, C.A.; Kurcon, T.; Mahal, L.K. MicroRNA-424 Predicts a Role for β-1,4 Branched Glycosylation in Cell Cycle Progression. J. Biol. Chem., 2016, 291, 1529-37. doi: 10.1074/jbc.M115.672220. 8. ^Mahal, L.K.; Yarema, K.J.; Bertozzi, C.R. Engineering Chemical Reactivity on Cell Surfaces Through Oligosaccharide Biosynthesis. Science 1997, 276, 1125-1128. 9. ^Lara Mahal's Research page at NYU 10. ^{{cite web|title=Lara K. Mahal |url=http://www.beckman-foundation.org/beckman-young-investigators/lara-k-mahal?A=SearchResult&SearchID=3907328&ObjectID=4732100&ObjectType=35|website=Arnold and Mabel Beckman Foundation|accessdate=9 March 2017}} 11. ^NIH Director's New Innovator Award 12. ^{{cite web |title=Horace S. Isbell Awardees |url=https://carb.sites.acs.org/isbellawardees.htm |website=Division of Carbohydrate Chemistry ACS CARB |accessdate=1 August 2018}} External links 6 : Living people|Year of birth missing (living people)|University of Texas at Austin faculty|University of California, Santa Cruz alumni|University of California, Berkeley alumni|New York University faculty |
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