| 释义 |
- References
- Further reading
{{Infobox_gene}}Probable leucyl-tRNA synthetase, mitochondrial is an enzyme that in humans is encoded by the LARS2 gene.[1][2]{{PBB_Summary
| section_title =
| summary_text = This gene encodes a class 1 aminoacyl-tRNA synthetase, mitochondrial leucyl-tRNA synthetase. Each of the twenty aminoacyl-tRNA synthetases catalyzes the aminoacylation of a specific tRNA or tRNA isoaccepting family with the cognate amino acid.[3]
}}References1. ^{{cite journal |vauthors=Sohm B, Sissler M, Park H, King MP, Florentz C | title = Recognition of human mitochondrial tRNALeu(UUR) by its cognate leucyl-tRNA synthetase | journal = J Mol Biol | volume = 339 | issue = 1 | pages = 17–29 |date=May 2004 | pmid = 15123417 | pmc = | doi = 10.1016/j.jmb.2004.03.066 }}
2. ^{{cite web | title = Entrez Gene: LARS2 leucyl-tRNA synthetase 2, mitochondrial| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23395| accessdate = }}
3. ^{{cite web | title = Entrez Gene: LARS2 leucyl-tRNA synthetase 2, mitochondrial| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23395| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Olsson P, Wennberg AL |title=[Midwife and research. Conference report] |journal=Jordemodern |volume=104 |issue= 11 |pages= 408–9, 404 |year= 1992 |pmid= 1684970 |doi= }}
- {{cite journal |vauthors=Nomura N, Miyajima N, Sazuka T, etal |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. |journal=DNA Res. |volume=1 |issue= 1 |pages= 27–35 |year= 1995 |pmid= 7584026 |doi=10.1093/dnares/1.1.27 }}
- {{cite journal |vauthors=Nomura N, Miyajima N, Sazuka T, etal |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement). |journal=DNA Res. |volume=1 |issue= 1 |pages= 47–56 |year= 1995 |pmid= 7584028 |doi=10.1093/dnares/1.1.47 }}
- {{cite journal |vauthors=Szeles A, Yang Y, Sandlund AM, etal |title=Human/mouse microcell hybrid based elimination test reduces the putative tumor suppressor region at 3p21.3 to 1.6 cM. |journal=Genes Chromosomes Cancer |volume=20 |issue= 4 |pages= 329–36 |year= 1998 |pmid= 9408748 |doi=10.1002/(SICI)1098-2264(199712)20:4<329::AID-GCC3>3.0.CO;2-3 }}
- {{cite journal |vauthors=Kiss H, Kedra D, Yang Y, etal |title=A novel gene containing LIM domains (LIMD1) is located within the common eliminated region 1 (C3CER1) in 3p21.3. |journal=Hum. Genet. |volume=105 |issue= 6 |pages= 552–9 |year= 2000 |pmid= 10647888 |doi=10.1007/s004390051144 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Yao YN, Wang L, Wu XF, Wang ED |title=The processing of human mitochondrial leucyl-tRNA synthetase in the insect cells. |journal=FEBS Lett. |volume=534 |issue= 1–3 |pages= 139–42 |year= 2004 |pmid= 12527375 |doi=10.1016/S0014-5793(02)03833-4 }}
- {{cite journal |vauthors=Park H, Davidson E, King MP |title=The pathogenic A3243G mutation in human mitochondrial tRNALeu(UUR) decreases the efficiency of aminoacylation |journal=Biochemistry |volume=42 |issue= 4 |pages= 958–64 |year= 2003 |pmid= 12549915 |doi= 10.1021/bi026882r }}
- {{cite journal |vauthors=Yao YN, Wang L, Wu XF, Wang ED |title=Human mitochondrial leucyl-tRNA synthetase with high activity produced from Escherichia coli |journal=Protein Expr. Purif. |volume=30 |issue= 1 |pages= 112–6 |year= 2004 |pmid= 12821328 |doi=10.1016/S1046-5928(03)00097-4 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Munakata K, Iwamoto K, Bundo M, Kato T |title=Mitochondrial DNA 3243A>G mutation and increased expression of LARS2 gene in the brains of patients with bipolar disorder and schizophrenia |journal=Biol. Psychiatry |volume=57 |issue= 5 |pages= 525–32 |year= 2005 |pmid= 15737668 |doi= 10.1016/j.biopsych.2004.11.041 }}
- {{cite journal |vauthors='t Hart LM, Hansen T, Rietveld I, etal |title=Evidence that the mitochondrial leucyl tRNA synthetase (LARS2) gene represents a novel type 2 diabetes susceptibility gene |journal=Diabetes |volume=54 |issue= 6 |pages= 1892–5 |year= 2005 |pmid= 15919814 |doi=10.2337/diabetes.54.6.1892 }}
{{refend}}{{gene-3-stub}} 1 : Biology of bipolar disorder |