| 词条 | Lerisetron |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 462090141 | IUPAC_name = 1-Benzyl-2-piperazin-1-yl-1H-benzimidazole | image = Lerisetron.svg | width = 175 | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|changed|??}} | CAS_number = 143257-98-1 | ATC_prefix = None | ATC_suffix = | PubChem = 65997 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}} | ChemSpiderID = 59389 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = Q36R82SXRG | ChEMBL_Ref = {{ebicite|correct|EBI}} | ChEMBL = 56900 | C=18 | H=20 | N=4 | molecular_weight = 292.378 g/mol | StdInChI_Ref = {{stdinchicite|correct|chemspider}} | StdInChI = 1S/C18H20N4/c1-2-6-15(7-3-1)14-22-17-9-5-4-8-16(17)20-18(22)21-12-10-19-11-13-21/h1-9,19H,10-14H2 | StdInChIKey_Ref = {{stdinchicite|correct|chemspider}} | StdInChIKey = PWWDCRQZITYKDV-UHFFFAOYSA-N | synonyms = F-0930-RS }}Lerisetron (code name F-0930-RS) is a drug which acts as an antagonist at the 5-HT3 receptor.[1] It is a potent antiemetic[2][3] and was in clinical trials for the treatment of nausea associated with cancer chemotherapy.[4] See also
References1. ^{{cite journal|last1=Orjales|first1=A|last2=Mosquera|first2=R|last3=Labeaga|first3=L|last4=Rodes|first4=R|title=New 2-Piperazinylbenzimidazole Derivatives as 5-HT3 Antagonists. Synthesis and Pharmacological Evaluation|journal=Journal of Medicinal Chemistry|date=14 February 1997|volume=40|issue=4|pages=586–93|doi=10.1021/jm960442e|pmid=9046349}} {{Serotonergics}}{{gastrointestinal-drug-stub}}2. ^{{cite journal|last1=Gomez-de-Segura|first1=IA|last2=Grande|first2=AG|last3=De Miguel|first3=E|title=Antiemetic Effects of Lerisetron in Radiation-Induced Emesis in the Dog|journal=Acta Oncologica|date=1998|volume=37|issue=7–8|pages=759–63|pmid=10050999}} 3. ^{{cite journal|last1=Cooper|first1=M|last2=Sologuren|first2=A|last3=Valiente|first3=R|last4=Smith|first4=J|title=Effects of Lerisetron, a New 5-HT3 Receptor Antagonist, on Ipecacuanha-Induced Emesis in Healthy Volunteers|journal=Arzneimittel-Forschung|date=2002|volume=52|issue=9|pages=689–94|doi=10.1055/s-0031-1299952|pmid=12404884}} 4. ^{{cite journal|last1=Huckle|first1=R|title=Lerisetron. FAES|journal=Current Opinion in Investigational Drugs|date=July 2003|volume=4|issue=7|pages=874–7|pmid=14619411}} 4 : 5-HT3 antagonists|Antiemetics|Benzimidazoles|Piperazines |
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