| 词条 | Leteprinim |
| 释义 |
| verifiedrevid = 444252852 | IUPAC_name = 4- | image = Leteprinim.png | width = 240 | tradename = | routes_of_administration = | elimination_half-life = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 138117-50-7 | ATC_prefix = none | ATC_suffix = | PubChem = 132123 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | UNII_Ref = {{fdacite|correct|FDA}} | UNII = NBY3IU407M | C=15 | H=13 | N=5 | O=4 | molecular_weight = 327.295 | smiles = C1=CC(=CC=C1C(=O)O)NC(=O)CCN2C=NC3=C2NC=NC3=O | ChemSpiderID = 116710 | StdInChI = 1S/C15H13N5O4/c21-11(19-10-3-1-9(2-4-10)15(23)24)5-6-20-8-18-12-13(20)16-7-17-14(12)22/h1-4,7-8H,5-6H2,(H,19,21)(H,23,24)(H,16,17,22) | StdInChIKey = JMPOIZCOJJMTHI-UHFFFAOYSA-N }}Leteprinim (Neotrofin, AIT-082) is a hypoxanthine derivative drug with neuroprotective and nootropic effects.[1][2][3] It stimulates release of nerve growth factors and enhances survival of neurons in the brain,[4][5][6][7][8] and is under development as a potential treatment for neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease and stroke.[9][10] References1. ^{{Cite journal|pmid=11358452|year=2001|author1=Di Iorio|first1=P|title=AIT-082 is neuroprotective against kainate-induced neuronal injury in rats|journal=Experimental Neurology|volume=169|issue=2|pages=392–9|last2=Virgilio|first2=A|last3=Giuliani|first3=P|last4=Ballerini|first4=P|last5=Vianale|first5=G|last6=Middlemiss|first6=P. J.|last7=Rathbone|first7=M. P.|last8=Ciccarelli|first8=R|doi=10.1006/exnr.2001.7654}} 2. ^{{Cite journal|pmid=10818529|year=2000|author1=Lahiri|first1=D. K.|title=Effect of a memory-enhancing drug, AIT-082, on the level of synaptophysin|journal=Annals of the New York Academy of Sciences|volume=903|pages=387–93|last2=Ge|first2=Y. W.|last3=Farlow|first3=M. R.|bibcode=2000NYASA.903..387L|doi=10.1111/j.1749-6632.2000.tb06390.x}} 3. ^{{Cite journal|pmid=12605287|year=2003|author1=Yan|first1=R|title=Reversal of cycloheximide-induced memory disruption by AIT-082 (Neotrofin) is modulated by, but not dependent on, adrenal hormones|journal=Psychopharmacology|volume=166|issue=4|pages=400–7|last2=Nguyen|first2=Q|last3=Gonzaga|first3=J|last4=Johnson|first4=M|last5=Ritzmann|first5=R. F.|last6=Taylor|first6=E. M.|doi=10.1007/s00213-002-1350-5}} 4. ^{{Cite journal|pmid=15992149|year=1999|author1=Rathbone|first1=M. P.|title=AIT-082 as a potential neuroprotective and regenerative agent in stroke and central nervous system injury|journal=Expert Opinion on Investigational Drugs|volume=8|issue=8|pages=1255–62|last2=Middlemiss|first2=P. J.|last3=Crocker|first3=C. E.|last4=Glasky|first4=M. S.|last5=Juurlink|first5=B. H.|last6=Ramirez|first6=J. J.|last7=Ciccarelli|first7=R|last8=Di Iorio|first8=P|last9=Caciagli|first9=F|doi=10.1517/13543784.8.8.1255}} 5. ^{{Cite journal|pmid=12237496|year=2002|author1=Ramirez|first1=J. J.|title=The effects of Neotrofin on septodentate sprouting after unilateral entorhinal cortex lesions in rats|journal=Restorative neurology and neuroscience|volume=20|issue=1–2|pages=51–9|last2=Parakh|first2=T|last3=George|first3=M. N.|last4=Freeman|first4=L|last5=Thomas|first5=A. A.|last6=White|first6=C. C.|last7=Becton|first7=A}} 6. ^{{Cite journal|pmid=14664808|year=2003|author1=Holmes|first1=M|title=Neotrofin, a novel purine that induces NGF-dependent nociceptive nerve sprouting but not hyperalgesia in adult rat skin|journal=Molecular and Cellular Neurosciences|volume=24|issue=3|pages=568–80|last2=Maysinger|first2=D|last3=Foerster|first3=A|last4=Pertens|first4=E|last5=Barlas|first5=C|last6=Diamond|first6=J|doi=10.1016/s1044-7431(03)00217-3}} 7. ^{{Cite journal|pmid=15461869|year=2004|author1=Jiang|first1=S|title=AIT-082 and methylprednisolone singly, but not in combination, enhance functional and histological improvement after acute spinal cord injury in rats|journal=International journal of immunopathology and pharmacology|volume=17|issue=3|pages=353–66|last2=Khan|first2=M. I.|last3=Middlemiss|first3=P. J.|last4=Lu|first4=Y|last5=Werstiuk|first5=E. S.|last6=Crocker|first6=C. E.|last7=Ciccarelli|first7=R|last8=Caciagli|first8=F|last9=Rathbone|first9=M. P.|doi=10.1177/039463200401700315}} 8. ^{{Cite journal|pmid=16507305|year=2006|author1=Calcutt|first1=N. A.|title=Protection of sensory function in diabetic rats by Neotrofin|journal=European Journal of Pharmacology|volume=534|issue=1–3|pages=187–93|last2=Freshwater|first2=J. D.|last3=Hauptmann|first3=N|last4=Taylor|first4=E. M.|last5=Mizisin|first5=A. P.|doi=10.1016/j.ejphar.2006.01.047}} 9. ^{{Cite journal|pmid=12231461|year=2002|author1=Potkin|first1=S. G.|title=Brain metabolic effects of Neotrofin in patients with Alzheimer's disease|journal=Brain Research|volume=951|issue=1|pages=87–95|last2=Alva|first2=G|last3=Keator|first3=D|last4=Carreon|first4=D|last5=Fleming|first5=K|last6=Fallon|first6=J. H.|doi=10.1016/s0006-8993(02)03140-2}} 10. ^{{Cite journal|pmid= 15298067|year= 2004|author1= Johnston|first1= T. H.|title= Drugs in development for Parkinson's disease|journal= Current Opinion in Investigational Drugs|volume= 5|issue= 7|pages= 720–6|last2= Brotchie|first2= J. M.}} External links
4 : Anilides|Benzoic acids|Nootropics|Purines |
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