| 词条 | Levophenacylmorphan |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 411037806 | IUPAC_name = (−)-3-Hydroxy-N-phenacylmorphinan | image = Levophenacylmorphan.svg | width = 150 | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = Schedule I | legal_UK = | legal_US = Schedule I | legal_DE = Anlage I | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 10061-32-2 | ATC_prefix = none | ATC_suffix = | PubChem = 5362482 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | UNII_Ref = {{fdacite|changed|FDA}} | UNII = 7Q24AL2BR2 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 16736786 | C=24 | H=27 | N=1 | O=2 | molecular_weight = 361.48 g/mol | smiles = C1CC[C@@]23CCN([C@@H]([C@@H]2C1)CC4=C3C=C(C=C4)O)CC(=O)C5=CC=CC=C5 | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C24H27NO2/c26-19-10-9-18-14-22-20-8-4-5-11-24(20,21(18)15-19)12-13-25(22)16-23(27)17-6-2-1-3-7-17/h1-3,6-7,9-10,15,20,22,26H,4-5,8,11-14,16H2/t20-,22+,24+/m0/s1 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = RCYBMSQOSGJZLO-BGWNEDDSSA-N | synonyms = Levophenacylmorphan }}Levophenacylmorphan is a morphinan derivative that acts as an opioid agonist. It has potent analgesic effects and is around 10x more potent than morphine.[1] Adverse effects associated with its use are those of the opioids as a whole, including pruritus, nausea, respiratory depression, euphoria and development of tolerance and dependence to its effects.[2] See also
References1. ^MAY, E.L. & EDDY, N.B., A New Potent Synthetic Analgesic, J. Org. Chem., 24 : 294, 1959. {{Opioidergics}}2. ^Fraser HF, Isbell H. Human pharmacology and addiction liabilities of phenazocine and levophenacylmorphan. UN Bulletin on Narcotics. 1960 Issue 2 5 : Ketones|Morphinans|Mu-opioid agonists|Phenols|Synthetic opioids |
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