| 释义 |
- Function
- See also
- References
- Further reading
- External links
{{Infobox_gene}}Leukocyte immunoglobulin-like receptor subfamily A member 2 (LILRA2, CD85H, ILT1) is a protein that in humans is encoded by the LILRA2 gene.[1][2][3]{{PBB_Summary
| section_title =
| summary_text = Leukocyte Ig-like receptors (LIRs) are a family of immunoreceptors expressed predominantly on monocytes and B cells and at lower levels on dendritic cells and natural killer (NK) cells. All LIRs in subfamily B have an inhibitory function (see, e.g., LILRB1, MIM 604811). LIRs in subfamily A, with short cytoplasmic domains lacking an immunoreceptor tyrosine-based inhibitory motif (ITIM) and with transmembrane regions containing a charged arginine residue, may initiate stimulatory cascades. One member of subfamily A (LILRA3; MIM 604818) lacks a transmembrane region and is presumed to be a soluble receptor.[supplied by OMIM][4]
}} Function LILRA2 senses microbially cleaved immunoglobulin to activate human myeloid cells.[5] See also- Cluster of differentiation
References1. ^{{cite journal |vauthors=Samaridis J, Colonna M | title = Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways | journal = Eur J Immunol | volume = 27 | issue = 3 | pages = 660–5 |date=Apr 1997 | pmid = 9079806 | pmc = | doi =10.1002/eji.1830270313 }}
2. ^{{cite journal |vauthors=Borges L, Hsu ML, Fanger N, Kubin M, Cosman D | title = A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules | journal = J Immunol | volume = 159 | issue = 11 | pages = 5192–6 |date=Apr 1998 | pmid = 9548455 | pmc = | doi = }}
3. ^{{cite web | title = Entrez Gene: LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11027| accessdate = }}
4. ^{{cite web | title = Entrez Gene: LILRA2 leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11027| accessdate = }}
5. ^{{cite journal | vauthors = Hirayasu K, Saito F, Suenaga T, Shida K, Arase N, Oikawa K, Yamaoka T, Murota H, Chibana H, Nagai H, Nakamura Y, Katayama I, Colonna M, Arase H | title = LILRA2 is an innate immune sensor for microbially cleaved immunoglobulins | journal = Nature Microbiology | volume = 1 | issue = 6 | pages = 16054 | date = Apr 2016 | doi =10.1038/NMICROBIOL.2016.54}}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
- {{cite journal |vauthors=Rojo S, Burshtyn DN, Long EO, Wagtmann N |title=Type I transmembrane receptor with inhibitory function in mouse mast cells and NK cells. |journal=J. Immunol. |volume=158 |issue= 1 |pages= 9–12 |year= 1997 |pmid= 8977169 |doi= }}
- {{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Tedla N, Bandeira-Melo C, Tassinari P, etal |title=Activation of human eosinophils through leukocyte immunoglobulin-like receptor 7. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 3 |pages= 1174–9 |year= 2003 |pmid= 12529506 |doi= 10.1073/pnas.0337567100 | pmc=298746 }}
- {{cite journal |vauthors=Nakajima H, Asai A, Okada A, etal |title=Transcriptional regulation of ILT family receptors. |journal=J. Immunol. |volume=171 |issue= 12 |pages= 6611–20 |year= 2004 |pmid= 14662864 |doi= 10.4049/jimmunol.171.12.6611}}
- {{cite journal |vauthors=Sloane DE, Tedla N, Awoniyi M, etal |title=Leukocyte immunoglobulin-like receptors: novel innate receptors for human basophil activation and inhibition. |journal=Blood |volume=104 |issue= 9 |pages= 2832–9 |year= 2004 |pmid= 15242876 |doi= 10.1182/blood-2004-01-0268 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
{{refend}}External links- {{MeshName|LILRA2+protein,+human}}
{{NLM content}}{{Clusters of differentiation}}{{membrane-protein-stub}}{{immunology-stub}} 2 : Clusters of differentiation|Immunoglobulin superfamily |