| 释义 |
- See also
- References
- Further reading
- External links
{{Infobox_gene}}Leukocyte immunoglobulin-like receptor subfamily A member 3 (LILR-A3) also known as CD85 antigen-like family member E (CD85e), immunoglobulin-like transcript 6 (ILT-6), and leukocyte immunoglobulin-like receptor 4 (LIR-4) is a protein that in humans is encoded by the LILRA3 gene located within the eukocyte receptor complex on chromosome 19q13.4. Unlike many of its family, LILRA3 lacks a transmembrane domain. The function of LILRA3 is currently unknown. however it is highly homologous to other LILR genes,[1] and can bind human leukocyte antigen (HLA) class I. Therefore, if secreted, the LILRA3 might impair interactions of membrane-bound LILRs (such as LILRB1, an inhibitory receptor expressed on effector and memory CD8 T cells) with their HLA ligands, thus modulating immune reactions and influencing susceptibility to disease.[2][3][4]Like the closely related LILRA1, LILRA3 binds to both normal and 'unfolded' free heavy chains of HLA class I, with a preference for free heavy chains of HLA-C alleles [5] See also - Cluster of differentiation
References 1. ^{{cite journal | vauthors = Torkar M, Haude A, Milne S, Beck S, Trowsdale J, Wilson MJ | title = Arrangement of the ILT gene cluster: a common null allele of the ILT6 gene results from a 6.7-kbp deletion | journal = European Journal of Immunology | volume = 30 | issue = 12 | pages = 3655–62 | date = December 2000 | pmid = 11169408 | pmc = | doi = 10.1002/1521-4141(200012)30:12<3655::aid-immu3655>3.0.co;2-y }}
2. ^{{cite journal | vauthors = Arm JP, Nwankwo C, Austen KF | title = Molecular identification of a novel family of human Ig superfamily members that possess immunoreceptor tyrosine-based inhibition motifs and homology to the mouse gp49B1 inhibitory receptor | journal = Journal of Immunology | volume = 159 | issue = 5 | pages = 2342–9 | date = September 1997 | pmid = 9278324 | pmc = | doi = }}
3. ^{{cite journal | vauthors = Borges L, Hsu ML, Fanger N, Kubin M, Cosman D | title = A family of human lymphoid and myeloid Ig-like receptors, some of which bind to MHC class I molecules | journal = Journal of Immunology | volume = 159 | issue = 11 | pages = 5192–6 | date = December 1997 | pmid = 9548455 | pmc = | doi = }}
4. ^{{cite web | title = Entrez Gene: LILRA3 leukocyte immunoglobulin-like receptor, subfamily A (without TM domain), member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11026| accessdate = }}
5. ^{{cite journal | vauthors = Jones DC, Kosmoliaptsis V, Apps R, Lapaque N, Smith I, Kono A, Chang C, Boyle LH, Taylor CJ, Trowsdale J, Allen RL | title = HLA class I allelic sequence and conformation regulate leukocyte Ig-like receptor binding | journal = Journal of Immunology | volume = 186 | issue = 5 | pages = 2990–7 | date = March 2011 | pmid = 21270408 | pmc = | doi = 10.4049/jimmunol.1003078 }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = Samaridis J, Colonna M | title = Cloning of novel immunoglobulin superfamily receptors expressed on human myeloid and lymphoid cells: structural evidence for new stimulatory and inhibitory pathways | journal = European Journal of Immunology | volume = 27 | issue = 3 | pages = 660–5 | date = March 1997 | pmid = 9079806 | doi = 10.1002/eji.1830270313 }}
- {{cite journal | vauthors = Cella M, Döhring C, Samaridis J, Dessing M, Brockhaus M, Lanzavecchia A, Colonna M | title = A novel inhibitory receptor (ILT3) expressed on monocytes, macrophages, and dendritic cells involved in antigen processing | journal = The Journal of Experimental Medicine | volume = 185 | issue = 10 | pages = 1743–51 | date = May 1997 | pmid = 9151699 | pmc = 2196312 | doi = 10.1084/jem.185.10.1743 }}
- {{cite journal | vauthors = Colonna M, Navarro F, Bellón T, Llano M, García P, Samaridis J, Angman L, Cella M, López-Botet M | title = A common inhibitory receptor for major histocompatibility complex class I molecules on human lymphoid and myelomonocytic cells | journal = The Journal of Experimental Medicine | volume = 186 | issue = 11 | pages = 1809–18 | date = December 1997 | pmid = 9382880 | pmc = 2199153 | doi = 10.1084/jem.186.11.1809 }}
- {{cite journal | vauthors = Wiśniewski A, Łuszczek W, Mańczak M, Jasek M, Kubicka W, Cislo M, Kuśnierczyk P | title = Distribution of LILRA3 (ILT6/LIR4) deletion in psoriatic patients and healthy controls | journal = Human Immunology | volume = 64 | issue = 4 | pages = 458–61 | date = April 2003 | pmid = 12651072 | doi = 10.1016/S0198-8859(03)00025-9 }}
- {{cite journal | vauthors = Norman PJ, Carey BS, Stephens HA, Vaughan RW | title = DNA sequence variation and molecular genotyping of natural killer leukocyte immunoglobulin-like receptor, LILRA3 | journal = Immunogenetics | volume = 55 | issue = 3 | pages = 165–71 | date = June 2003 | pmid = 12750859 | doi = 10.1007/s00251-003-0561-1 }}
- {{cite journal | vauthors = Zhang Z, Henzel WJ | title = Signal peptide prediction based on analysis of experimentally verified cleavage sites | journal = Protein Science | volume = 13 | issue = 10 | pages = 2819–24 | date = October 2004 | pmid = 15340161 | pmc = 2286551 | doi = 10.1110/ps.04682504 }}
{{refend}} External links - {{MeshName|LILRA3+protein,+human}}
{{NLM content}}{{Clusters of differentiation}}{{immunology-stub}}{{membrane-protein-stub}}{{gene-19-stub}} 2 : Clusters of differentiation|Immunoglobulin superfamily |