The show broadcasts Sundays through Thursdays, with no show on Friday or Saturday. Since it broadcasts at 10 p.m. to 12 a.m PT occasionally shows will be listed incorrectly with the next day's date. If a show's date corresponds to a Friday or a Saturday, it is almost certainly incorrect. Sunday episodes are identified in the table by gray shading.
| Date | Guest(s) | Notes |
|---|
| 2006-01-01 | Best of Loveline, with Steve-O |
| 2006-01-02 | Joel McHale | From the TV show The Soup |
| 2006-01-03 | Rob Schneider |
| 2006-01-04 | John Hensley | From the TV show Nip-Tuck |
| 2006-01-05 | Rob Schneider |
| 2006-01-08 | Lisa Guerrero | From the TV show Monday Night Football |
| 2006-01-09 | Lisa Guerrero | From the TV show The Best Damn Sports Show Period |
| 2006-01-10 | Seth Green | From the TV show Four Kings |
| 2006-01-11 | Alanis Morissette |
| 2006-01-12 | Jay Hernandez | From the movie Hostel |
| 2006-01-15 | Steve-O | From the TV show Wildboyz |
| 2006-01-16 | Alex Hooser & Alex Murrel | From the TV show The Real Orange County |
| 2006-01-17 | Elisha Cuthbert | From the movie Captivity |
| 2006-01-18 | Jenna Fischer | From the TV show The Office |
| 2006-01-19 | Justin Warfield & Adam Bravin | From the band She Wants Revenge |
| 2006-01-22 | Steve-O | From the TV show Wildboyz |
| 2006-01-23 | Joe Rogan | From the TV show Fear Factor |
| 2006-01-24 | Adam Goldstein | aka DJ AM |
| 2006-01-25 | Danny Bonaduce | From the TV show Breaking Bonaduce |
| 2006-01-26 | Danny & Gretchen Bonaduce | From the TV show Breaking Bonaduce |
| 2006-01-29 | Joel McHale | From the TV show The Soup |
| 2006-01-30 | Paul "Sonny" Sandoval & Noah "Wuv" Bernardo | From the band P.O.D. |
| 2006-01-31 | Busy Philipps | From the TV show Love, Inc. |
| 2006-02-01 | Rainn Wilson & B.J. Novak | From the TV show The Office |
| 2006-02-02 | Alex Borstein | From the TV show Family Guy |
| 2006-02-05 | Dan Layus, Jared Palomar & Justin South | From the band Augustana |
| 2006-02-06 | Ryan Key | From the band Yellowcard |
| 2006-02-07 | Rob Schneider |
| 2006-02-08 | Andy Milonakis | From the movie Waiting... |
| 2006-02-09 | Patrick Stump & Pete Wentz | From the band Fall Out Boy |
| 2006-02-12 | David Martin Blake | aka DJ Quik |
| 2006-02-13 | Nick Hexum | From the band 311 |
| 2006-02-14 | Best of Loveline, with Jonathan Davis, Mike Shinoda, B-Real |
| 2006-02-15 | David Alan Grier |
| 2006-02-16 | Shanna Moakler | From the TV show Meet the Barkers |
| 2006-02-19 | Hosted by Dr. Drew & Fred Durst |
| 2006-02-20 | Hosted by Dr. Drew & Fred Durst |
| 2006-02-21 | Hosted by Dr. Drew & Fred Durst |
| 2006-02-22 | Scott Thomas, Brian Bell & Wes Scantlin | From the bands Ringside, Weezer & Puddle of Mudd. Hosted by Dr. Drew & Fred Durst |
| 2006-02-23 | Joel McHale | From the TV show The Soup |
| 2006-02-26 | Ville Valo | From the band HIM |
| 2006-02-27 | No Guest |
| 2006-02-28 | Best of Loveline, with Elisha Cuthbert, Joe Rogan |
| 2006-03-01 | Danny Bonaduce | From the TV show Breaking Bonaduce |
| 2006-03-02 | Andy Milonakis | From the TV show The Andy Milonakis Show |
| 2006-03-05 | Steve-O |
| 2006-03-06 | Tom Green & Loni Anderson |
| 2006-03-07 | Jon Lovitz |
| 2006-03-08 | Dave Attell | From the TV show Insomniac with Dave Attell |
| 2006-03-09 | Lisa Edelstein | From the TV show House |
| 2006-03-12 | Josh Meyers | From the TV show That '70s Show |
| 2006-03-13 | Eric Balfour | From the TV show Conviction |
| 2006-03-14 | No Guest |
| 2006-03-15 | Danny Bonaduce | From the TV show Breaking Bonaduce |
| 2006-03-16 | Christian Finnegan | From the TV show Best Week Ever |
| 2006-03-19 | Joel McHale | From the TV show The Soup |
| 2006-03-20 | Carson Daly | From the TV show Last Call with Carson Daly |
| 2006-03-21 | Carson Daly | From the TV show Last Call with Carson Daly |
| 2006-03-22 | Gregory Itzin | From the TV show 24 |
| 2006-03-23 | Amanda Walsh, Randy Wayne & Greg Pitts | From the TV show Sons & Daughters |
| 2006-03-26 | Best of Loveline, with Jack Osbourne, Rob Schneider |
| 2006-03-27 | Best of Loveline, with Ville Valo, Rainn Wilson & B.J. Novak |
| 2006-03-28 | Best of Loveline, with Fred Durst, Joel McHale |
| 2006-03-29 | Best of Loveline, with DJ-AM, The All-American Rejects, Busy Philipps |
| 2006-03-30 | Best of Loveline, with AFI, Alex Borstein, Seth Green |
| 2006-04-02 | Taylor Hawkins & Chris Chaney | From the band Taylor Hawkins and the Coattail Riders |
| 2006-04-03 | JT Woodruff, Micah Carli & Matt Ridenour | From the band Hawthorne Heights |
| 2006-04-04 | Seth Green | From the TV show Robot Chicken |
| 2006-04-05 | Anna Faris | From the movie Scary Movie 4 |
| 2006-04-06 | Adam de la Peña | From the TV show Minoriteam |
| 2006-04-09 | Daniel Tosh |
| 2006-04-10 | Daniel Tosh |
| 2006-04-11 | Andrew McMahon & Jon "Dr. J" Sullivan | From the band Jack's Mannequin |
| 2006-04-12 | Autumn Reeser | From the TV show The O.C. |
| 2006-04-13 | Joel McHale | From the TV show The Soup |
| 2006-04-16 | David Alan Grier |
| 2006-04-17 | Tom Green |
| 2006-04-18 | Tom Green |
| 2006-04-19 | John Dolmayan | From the band System of a Down. Hosted by Dr. Drew & Nicole Alvarez |
| 2006-04-20 | Hosted by Dr. Drew & Nicole Alvarez |
| 2006-04-23 | No Guest |
| 2006-04-24 | Joel McHale | From the TV show The Soup |
| 2006-04-25 | Steve-O |
| 2006-04-26 | Steve-O | Hosted by Dr. Drew & Nicole Alvarez |
| 2006-04-27 | Hosted by Dr. Drew & Nicole Alvarez |
| 2006-04-30 | Daniel Tosh |
| 2006-05-01 | Daniel Tosh |
| 2006-05-02 | B-Real | From the band Cypress Hill |
| 2006-05-03 | Sully Erna & Shannon Larkin | From the band Godsmack |
| 2006-05-04 | Danny Bonaduce | From the TV show Breaking Bonaduce |
| 2006-05-07 | Joel McHale | From the TV show The Soup |
| 2006-05-08 | Kyle Cease | From the TV show Comedy Central Presents Kyle Cease |
| 2006-05-09 | Patton Oswalt | From the TV show The King of Queens |
| 2006-05-10 | Jeff Probst | From the TV show Survivor |
| 2006-05-11 | Ville Valo | From the band HIM. Hosted by Dr. Drew & Nicole Alvarez |
| 2006-05-14 | Hosted by Dr. Drew & Danny Bonaduce |
| 2006-05-15 | Hosted by Dr. Drew & Danny Bonaduce |
| 2006-05-16 | Doug Robb & Dan Estrin | From the band Hoobastank. Hosted by Dr. Drew & Danny Bonaduce |
| 2006-05-17 | Hosted by Dr. Drew & Danny Bonaduce |
| 2006-05-18 | Hosted by Dr. Drew & Danny Bonaduce |
| 2006-05-21 | Tim McIlrath, Brandon Barnes, Joe Principe & Chris Chasse | From the band Rise Against |
| 2006-05-22 | Alanna Ubach |
| 2006-05-23 | Steve-O |
| 2006-05-24 | Steve-O |
| 2006-05-25 | Best of Loveline, with Joel McHale, Daniel Tosh |
| 2006-05-28 | Best of Loveline, with Carson Daly, Patton Oswalt |
| 2006-05-29 | Alanna Ubach, Skyler Stone | From the TV show Con |
| 2006-05-30 | Ian Watkins & Jamie Oliver | From the band Lostprophets |
| 2006-05-31 | Dane Cook |
| 2006-06-01 | Jamie Kennedy | From the TV show Blowin' Up |
| 2006-06-04 | Davey Havok & Hunter Burgan | From the band AFI |
| 2006-06-05 | Bert Kreischer | From the movie Best in Town |
| 2006-06-06 | Joe Rogan | From the TV show Fear Factor. Stryker's first show as (unofficial) co-host. |
| 2006-06-07 | Harland Williams |
| 2006-06-08 | Best of Loveline |
| 2006-06-11 | Justin Warfield & Adam Bravin | From the band She Wants Revenge |
| 2006-06-12 | Tom Green |
| 2006-06-13 | Matt Rubano & Adam Lazzara | From the band Taking Back Sunday |
| 2006-06-14 | Brian Deegan |
| 2006-06-15 | Jared Leto & Shannon Leto | From the band Thirty Seconds to Mars |
| 2006-06-18 | Adam de la Peña | From the TV show Minoriteam |
| 2006-06-19 | Jay Mohr didn't show up |
| 2006-06-20 | Jeff Ross | From the TV show Where My Dogs At? |
| 2006-06-21 | Best of Loveline, with Dane Cook, AFI, Danny Bonaduce, Fall Out Boy, Jamie Kennedy |
| 2006-06-22 | Best of Loveline, with Jeff Probst, Shanna Moakler, Carson Daly. Seth Green |
| 2006-06-25 | Brandon Saller, Dan Jacobs & Travis Miguel | From the band Atreyu |
| 2006-06-26 | Bert Kreischer | From the movie Best in Town |
| 2006-06-27 | Justin Furstenfeld & Ryan Delahoussaye | From the band Blue October |
| 2006-06-28 | Evan Seinfeld & Tera Patrick | From the TV show SuperGroup |
| 2006-06-29 | No Guest |
| 2006-07-02 | Best of Loveline, with Andy Milonakis, Dave Attell |
| 2006-07-03 | Best of Loveline, with Joel McHale, Tom Green |
| 2006-07-04 | No episode was broadcast |
| 2006-07-05 | The Pink Spiders |
| 2006-07-06 | Chris Cheney, Scott Owen & Andy Strachan | From the band The Living End |
| 2006-07-09 | Stormy Daniels |
| 2006-07-10 | No Guest |
| 2006-07-11 | No Guest |
| 2006-07-12 | Chris Dudley, Aaron Gillespie, Spencer Chamberlain, Grant Brandell, Tim McTague & James Smith | From the band Underoath |
| 2006-07-13 | Matthew Bellamy & Dominic Howard | From the band Muse |
| 2006-07-16 | Rainn Wilson | From the TV show The Office |
| 2006-07-17 | Christopher Knight & Adrianne Curry |
| 2006-07-18 | Joe Francis | Of Girls Gone Wild infamy |
| 2006-07-19 | Tom Delonge & Atom Willard | From the band Angels & Airwaves |
| 2006-07-20 | Jonathan Davis | From the band Korn |
| 2006-07-23 | Stryker now "officially" hired as co-host. |
| 2006-07-24 | No Guest |
| 2006-07-25 | Mike Patton & Rahzel Brown | From the band Peeping Tom |
| 2006-07-26 | Akil & DJ Nu-Mark | From the band Jurassic 5 |
| 2006-07-27 | Art Alexakis | From the band Everclear |
| 2006-07-30 | Best of Loveline, with Angels & Airwaves, Christopher Knight & Adrianne Curry, Joe Francis |
| 2006-07-31 | Flavor Flav & Heidi Montag |
| 2006-08-01 | Mike Metzger |
| 2006-08-02 | Ryan Key | From the band Yellowcard |
| 2006-08-03 | Justin Long | From the movie Accepted. Hosted by Dr. Bruce & Stryker |
| 2006-08-06 | Hosted by Dr. Rey & Stryker |
| 2006-08-07 | Harland Williams | From the movie Employee of the Month. Hosted by Dr. Bruce & Stryker |
| 2006-08-08 | Cedric Yarbrough | From the TV show Reno 911!. Hosted by Dr. Bruce & Stryker |
| 2006-08-09 | Hosted by Dr. Alter & Stryker |
| 2006-08-10 | Torrie Wilson | Hosted by Dr. Bruce & Stryker |
| 2006-08-13 | Hosted by Dr. Bruce & Stryker |
| 2006-08-14 | Joanna Angel |
| 2006-08-15 | Gabe Saporta, Maja Ivarsson, Travis McCoy & William Beckett | From the bands Cobra Starship, Midtown, The Sounds, Gym Class Heroes & The Academy Is.... Hosted by Dr. Bruce & Stryker |
| 2006-08-16 | Hosted by Dr. Bruce & Stryker |
| 2006-08-17 | Dave Navarro & Steve Isaacs | From the band The Panic Channel |
| 2006-08-20 | No Guest |
| 2006-08-21 | Adam Goldstein | aka DJ AM |
| 2006-08-22 | Chelsea Handler | From the TV show The Chelsea Handler Show |
| 2006-08-23 | Tommy & Shelby Chong |
| 2006-08-24 | Adam Gontier & Brad Walst | From the band Three Days Grace |
| 2006-08-27 | Elisha Cuthbert | From the movie The Quiet |
| 2006-08-28 | Josh Todd & Keith Nelson | From the band Buckcherry |
| 2006-08-29 | Efren Ramirez | From the movie Crank |
| 2006-08-30 | Kendra Wilkinson, Holly Madison & Bridget Marquardt | From the TV show The Girls Next Door |
| 2006-08-31 | No Guest |
| 2006-09-03 | Replay of 2006-08-20 |
| 2006-09-04 | No Guest |
| 2006-09-05 | Norm Macdonald |
| 2006-09-06 | No Guest |
| 2006-09-07 | David Buckner & Jacoby Shaddix | From the band Papa Roach |
| 2006-09-10 | Tim Pagnotta & Marko 72 | From the band Sugarcult |
| 2006-09-11 | No Guest |
| 2006-09-12 | No Guest |
| 2006-09-13 | Affion Crockett |
| 2006-09-14 | Plain White T's |
| 2006-09-17 | Joel McHale | From the TV show The Soup |
| 2006-09-18 | No Guest |
| 2006-09-19 | Seth Green | From the TV show Robot Chicken |
| 2006-09-20 | Bam Margera |
| 2006-09-21 | Atreyu |
| 2006-09-24 | Dr. Rey |
| 2006-09-25 | Ron Livingston & Rosemarie DeWitt | From the TV show Standoff |
| 2006-09-26 | Steve-O & Jason Acuna | From the movie Jackass Number Two |
| 2006-09-27 | Andy Dick | From the movie Employee of the Month |
| 2006-09-28 | No Guest |
| 2006-10-01 | Brandon Flowers & Dave Keuning | From the band The Killers |
| 2006-10-02 | John Hensley | From the TV show Nip/Tuck |
| 2006-10-03 | Pepper |
| 2006-10-04 | Jeremy McGrath |
| 2006-10-05 | Dane Cook canceled |
| 2006-10-08 | Chester Bennington | From the band Linkin Park |
| 2006-10-09 | Dax Shepard | From the movie Employee of the Month |
| 2006-10-10 | Jeff Probst | From the TV show Survivor |
| 2006-10-11 | Diora Baird |
| 2006-10-12 | No Guest |
| 2006-10-15 | No Guest |
| 2006-10-16 | Xzibit |
| 2006-10-17 | Damian Kulash | From the band OK Go |
| 2006-10-18 | Elijah Blue Allman | From the band Deadsy |
| 2006-10-19 | Jamie Kennedy |
| 2006-10-22 | No Guest |
| 2006-10-23 | Mercedes McNab |
| 2006-10-24 | Angela Kinsey & Brian Baumgartner | From the TV show The Office |
| 2006-10-25 | No Guest |
| 2006-10-26 | No Guest |
| 2006-10-29 | No Guest |
| 2006-10-30 | James Van Praagh |
| 2006-10-31 | Best of Loveline |
| 2006-11-01 | Rise Against |
| 2006-11-02 | Travis Barker | From the band +44 |
| 2006-11-05 | Cisco Adler |
| 2006-11-06 | Deftones |
| 2006-11-07 | Tony Hawk |
| 2006-11-08 | No Guest |
| 2006-11-09 | No Guest |
| 2006-11-12 | Ice-T & Coco |
| 2006-11-13 | Bridget Marquardt |
| 2006-11-14 | Sean Avery |
| 2006-11-15 | Jenna Fischer & James Gunn | From the TV show The Office |
| 2006-11-16 | No Guest |
| 2006-11-19 | No Guest |
| 2006-11-20 | Greg Behrendt |
| 2006-11-21 | Jeffrey Sebelia | From the TV show Project Runway |
| 2006-11-22 | No Guest |
| 2006-11-23 | Replay of 2006-11-09 |
| 2006-11-26 | Cindy Margolis |
| 2006-11-27 | Paige Hemmis | From the TV show Home Edition |
| 2006-11-28 | No Guest |
| 2006-11-29 | Incubus |
| 2006-11-30 | Adam Goldberg | From the movie Déjà Vu |
| 2006-12-03 | No Guest |
| 2006-12-04 | No Guest |
| 2006-12-05 | John Dolmayan | From the band System of a Down |
| 2006-12-06 | She Wants Revenge |
| 2006-12-07 | No Guest |
| 2006-12-10 | No Guest |
| 2006-12-11 | Wolfmother |
| 2006-12-12 | Brian Deegan |
| 2006-12-13 | Adrienne Curry & Christopher Knight | From the TV show Celebrity Paranormal Project |
| 2006-12-14 | Spike Feresten | From the TV show Talkshow with Spike Feresten |
| 2006-12-17 | No Guest |
| 2006-12-18 | No Guest |
| 2006-12-19 | Sen Dog & Mellow Man Ace | From the band Cypress Hill |
| 2006-12-20 | Ken Davitian | From the movie Borat |
| 2006-12-21 | Replay of 2006-12-11 |
| 2006-12-24 | Best of Loveline |
| 2006-12-25 | No episode was broadcast |
| 2006-12-26 | Best of Loveline |
| 2006-12-27 | Best of Loveline |
| 2006-12-28 | Best of Loveline |
| 2006-12-31 | No episode was broadcast |