This is a list of the number-one hits of 2001 on Italian Hit Parade Singles Chart.[1]
| Issue date | Song | Artist | Album | Artist | | 5 January | "Goodnight Moon" | Shivaree | 1 | The Beatles |
| 12 January | "Love Don't Cost a Thing" | Jennifer Lopez |
| 19 January | "Io sono Francesco" | Tricarico | Amore nel pomeriggio | Francesco De Gregori |
| 26 January | "Stuck in a Moment You Can't Get Out Of" | U2 |
| 2 February | "Goodnight Moon" | Shivaree | Esco di rado e parlo ancora meno | Adriano Celentano |
| 9 February |
| 16 February |
| 23 February | "Stan" | Eminem featuring Dido |
| 2 March | "Luce (tramonti a nord est)" | Elisa | Il cammino dell'età | Gigi D'Alessio |
| 9 March |
| 16 March | Esco di rado e parlo ancora meno | Adriano Celentano |
| 23 March |
| 30 March | "Down Down Down" | Lollipop | Live in New York City | Bruce Springsteen & the E Street Band |
| 6 April | Stupido hotel | Vasco Rossi |
| 13 April |
| 20 April | "Dream On" | Depeche Mode |
| 27 April | "Down Down Down" | Lollipop |
| 4 May | "It's Raining Men" | Geri Halliwell |
| 11 May | "Me Gustas Tú" | Manu Chao | Reveal | R.E.M. |
| 18 May | "Clint Eastwood" | Gorillaz |
| 25 May | "It's Raining Men" | Geri Halliwell | Stupido hotel | Vasco Rossi |
| 1 June | Esperanza | Manu Chao |
| 8 June |
| 15 June |
| 22 June | Uno in più | 883 |
| 29 June |
| 6 July | "Infinito" | Raf |
| 13 July | "Baila (Sexy Thing)" | Zucchero | Stupido hotel | Vasco Rossi |
| 20 July | "Tre parole" | Valeria Rossi |
| 27 July | Circo Massimo 2001 | Antonello Venditti |
| 3 August | Stupido hotel | Vasco Rossi |
| 10 August |
| 17 August |
| 24 August |
| 31 August | A Funk Odyssey | Jamiroquai |
| 7 September | "Xdono" | Tiziano Ferro |
| 14 September | Shake | Zucchero |
| 21 September |
| 28 September |
| 5 October | "Can't Get You Out of My Head" | Kylie Minogue |
| 12 October | E ritorno da te | Laura Pausini |
| 19 October |
| 26 October | LU*CA | Luca Carboni |
| 2 November | The Best of Pink Floyd | Pink Floyd |
| 9 November | La curva dell'angelo | Renato Zero |
| 16 November | Echoes: The Best of Pink Floyd | Pink Floyd |
| 23 November |
| 30 November |
| 7 December |
| 14 December | "Somethin' Stupid" | Robbie Williams and Nicole Kidman |
| 21 December | "Paid My Dues" | Anastacia |
| 28 December | The Best of Laura Pausini: E ritorno da te | Laura Pausini |
1. ^Hit Parade Italia