| Name | Nationality | Anderlecht career | Matches | Honours | | Sylva Brébart | {{BEL}} | 1920–22 | 51 | Promotion to First Division (3rd in Promotion in 1920–21) |
| Charles Bunyan, Sr. | {{ENG}} | 1922 | 0 | In charge for 10 days before dying |
| Cyrille Bunyan | {{ENG}} | 1922–25 | 78 | Promotion to First Division (1st in Promotion in 1923–24) |
| Lee Thomas | {{ENG}} | 1926–28[2] | 55 | Promotion to Premier Division (2nd in First Division in 1926–27) |
| Florimond Plasch | {{BEL}} | 1928–31 | 78 | Promotion to Premier Division (2nd in First Division in 1928–29) |
| Ferdinand Adams | {{BEL}} | 1930–32[3] and 1940–43[4] | 65 |
| Maurice Versé | {{BEL}} | 1931–33 | 52 |
| Charles Gilis | {{BEL}} | 1932–35[3] and 1935–36 | 46 | Promotion to Premier Division (1st in First Division in 1934–35) |
| Claude Leclercq | {{BEL}} | 1933–34[5] | 32 |
| Ernest Churchill Smith | {{IRL}} | 1936–39 and 1948–50 | 138 | 2 Premier Division titles in 1948–49 and 1949–50 |
| Robert Wijckaert | {{BEL}} | 1939–45[4] | 162 |
| Emile Defevere | {{BEL}} | 1939–45[4] | 178 |
| Paul Schuppen | {{BEL}} | 1945–46[6] | 6 |
| John Kennedy | {{ENG}} | 1946 | 14 |
| Martin McLaren | {{ENG}} | 1946 | 8 |
| Georges Perino | {{FRA}} | 1946–48 | 58 | The first Premier Division title of RSC Anderlecht in 1946–47 |
| Bill Gormlie | {{ENG}} | 1950–59 | 294 | 5 First Division titles in 1950–51, 1953–54, 1954–55, 1955–56 and 1958–59 |
| Arnold Deraeymaeker | {{BEL}} | 1959–60[6] and 1968[6] | 43 |
| Pierre Sinibaldi | {{FRA}} | 1960–66 and 1969–71 | 293 | 4 First Division titles in 1961–62, 1963–64, 1964–65 and 1965–66 and 1 Cup in 1964–65 |
| Andras Beres | {{HUN}}
{{BEL}} | 1966–68 | 59 | 1 First Division title in 1966–67 |
| Norberto Höfling | {{ROM}}
{{BEL}} | 1968–69 | 22 |
| Hippolyte Van Den Bosch | {{BEL}} | 1971[6] and 1972–73[6] | 29 | 1 Cup in 1972–73 |
| Georg Keßler | {{FRG}} | 1971–72 | 58 | 1 First Division title in 1971–72 and 1 Cup in 1971–72 |
| Urbain Braems | {{BEL}} | 1973–75 and 1979–80 | 127 | 1 First Division title in 1973–74 and 1 Cup in 1974–75 |
| Hans Croon | {{NED}} | 1975–76 | 51 | 1 Cup in 1975–76 and 1 European Cup Winners' Cup in 1975–76 |
| Raymond Goethals | {{BEL}} | 1976–79, 1988–89 and 1995[6] | 213 | 2 Cups in 1987–88 and 1988–89 and 1 European Cup Winners' Cup in 1977–78 and 2 UEFA Super Cups in 1976 and 1978 |
| Tomislav Ivić | {{YUG}} | 1980–82 | 94 | 1 First Division title in 1980–81 |
| Paul Van Himst | {{BEL}} | 1982–85 | 155 | 1 First Division title in 1984–85, 1 Belgian Supercup in 1985 and 1 UEFA Cup in 1982–83 |
| Martin Lippens | {{BEL}} | 1985–86[6] and 1988–89 | 69 | 2 Cups in 1987–88 and 1988–89 |
| Jean Dockx | {{BEL}} | 1985–86,[6] 1995,[6] 1997[6] and 1998–99 | 36 |
| Arie Haan | {{NED}} | 1986–87 and
Dec 1997–Sept 98 | 100 | 2 First Division titles in 1985–86 and 1986–87 |
| Georges Leekens | {{BEL}} | 1987–88 | 32 | 1 Belgian Supercup in 1987 |
| Aad de Mos | {{NED}} | 1989–92 | 141 | 1 First Division title in 1990–91 |
| Luka Peruzović | {{CRO}} | 1992–93 | 26 |
| Johan Boskamp | {{NED}} | 1993–95 and 1995–97 | 198 | 3 First Division titles in 1992–93, 1993–94 and 1994–95, 1 Cup in 1993–94 and 1 Belgian Supercup in 1993 |
| Herbert Neumann | {{GER}} | 1995 | 4 |
| René Vandereycken | {{BEL}} | July 1997–Dec 97 | 20 |
| Franky Vercauteren | {{BEL}} | 1998–99 and
Feb 2005–Nov 07 | 156 | 2 First Division titles in 2005–06 and 2006–07 and 2 Belgian Supercups in 2006 and 2007 |
| Aimé Anthuenis | {{BEL}} | 1999–July 02 | 141 | 2 First Division titles in 1999–00 and 2000–01 and 2 Belgian Supercups in 2000 and 2001 |
| Hugo Broos | {{BEL}} | July 2002–Feb 05 | 126 | 1 First Division title in 2003–04 |
| Ariel Jacobs | {{BEL}} | Nov 2007–May 12 | 175 | 2 First Division titles in 2009–10 and 2011–12, 1 Cup title in 2007–08 and 1 Belgian Supercup in 2010 |
| John van den Brom | {{NED}} | July 2012–March 14 |
| Besnik Hasi | {{ALB}}
{{KOS}} | March 2014–May 2015 | | 1 First Division title in 2013-14 and 1 Belgian Supercup in 2014 |
| René Weiler | {{SUI}} | July 2016–September 2017 | | 1 First Division title in 2016-17 and 1 Belgian Supercup in 2017 |
| Hein Vanhaezebrouck | {{BEL}} | October 2017-December 2018 | |
| Fred Rutten | {{NED}} | January 2019-Present |
1. ^{{cite book |first=Marcel|last=Gallez|author2=Serkijn, Johan | year=2008 | title=Le dictionnaire du RSC Anderlecht (tome 2) | publisher=Magnad|isbn=978-2-9600723-3-4}}
2. ^No manager was appointed during the 1925–26 season
3. ^1 Served as trainer during this period
4. ^1 2 During the 1941–42 and 1942–43 seasons 3 managers were working together: Ferdinand Adams, Robert Wijckaert and Emile Defevere. Before the next season, Ferdinand Adams left the trio and Robert Wijckaert left before the 1945–46 season.
5. ^After Claude Leclercq was sacked during the 1934–35 season, a committee used to select the players until the end of the season
6. ^1 2 3 4 5 6 7 8 9 Served as caretaker manager.
{{R.S.C. Anderlecht}} 2 : R.S.C. Anderlecht managers|Lists of association football managers