The table below shows the ten tallest buildings in Jackson, Mississippi, United States.
The city has the third-tallest building (Regions Plaza, at {{convert|318|ft}}) in the state of Mississippi. The two tallest buildings in the state are the {{convert|348|ft|m|adj=mid|-tall}} Beau Rivage Hotel and the {{convert|335|ft|m|adj=mid|-tall}} IP Casino Hotel, both located in Biloxi.
See: List of tallest buildings in Mississippi.
| Rank | Name | Image | Height
ft (m) | Floors | Year | Notes |
|---|
| 1 | Regions Plaza | 318 (97) | 22 | 1975 | Tallest building in Jackson since its completion in 1975. |
| 2 | Jackson Marriott Downtown | 255 (78) | 21 | 1975 |
| 3 | Regions Bank Building | 254 (77) | 18 | 1929 | Tallest building in Jackson from 1929 to 1975. |
| 4 | Walter Sillers State Office Building | 250 (76) | 20 | 1972 |
| 5 | Standard Life Building | 250 (76) | 22 | 1929 | Renovated and converted into residential and retail in 2010. |
| 6 | Capital Towers Building | 245 (74) | 20 | 1965 |
| 7 | Trustmark National Bank Building | 215 (66) | 14 | 1955 |
| 8 | Lamar Life Building | 191 (58) | 10 | 1924 | Tallest building in Jackson from 1924 to 1929. |
| 9 | Dr. A. H. McCoy Federal Building | - | 189 (58) | 15 | 1979 | Renovated in 2013. |
| 10 | Mississippi State Capitol | 180 (55) | 4 | 1903 | Tallest building in Jackson from 1903 to 1924. |
| 11 | St. Dominic's Ambulatory Surgery Center | - | 176 (54) | 14 | 1973 | Tallest building outside of Downtown Jackson. |
| 12 | Hilton Hotel Jackson | - | 176 (54) | 14 | 1985 | Second-tallest building outside of Downtown Jackson. |
| 13 | One Jackson Place | - | 176 (54) | 14 | 1987 |
| 14 | Woolfolk State Office Building | 169 (52) | 16 | 1949 |
| 15 | King Edward Hotel (Jackson, Mississippi) | - | 156 (48) | 12 | 1923 | Renovated and converted into hotel, residential, and retail in 2009. |
| 16 | The Pinnacle at Jackson Place | - | 144 (44) | 9 | 2008 |
| 17 | City Centre South | - | 143 (44) | 12 | 1958 | Renovated in 1987. |
| 18 | Electric 308 | - | 126 (38) | 10 | 1927 | Renovated and converted into residential and office in 2005. |
|