“LL37”的意思、由来-开放百科全书

NOTE: This article appears to be split into two parts; more on cathelicidin's clinical significance can be found on the cathelicidin page.

Patients with rosacea have elevated levels of cathelicidin. Cathelicidin is cleaved into the antimicrobial peptide LL-37 by both kallikrein 5 and kallikrein 7 serine proteases. Excessive production of LL-37 is suspected to be a contributing cause in all subtypes of Rosacea.^[3]

Higher plasma levels of LL-37, which are up-regulated by vitamin D, appear to significantly reduce the risk of death from infection in dialysis patients. Patients with a high level of LL-37 were 3.7 times more likely to survive kidney dialysis for a year without a fatal infection.^[4] Vitamin D up-regulates genetic expression of cathelicidin, which exhibits broad-spectrum microbicidal activity against bacteria, fungi, and viruses.^[5]^[6]

SAAP-148 (a synthetic antimicrobial and antibiofilm peptide) is a modified version of LL-37 that has enhanced antimicrobial activities compared to LL-37. In particular, SAAP-148 was more efficient in killing bacteria under physiological conditions.^[7]

See also

References

1. ^{{cite web | title = Entrez Gene: CAMP cathelicidin antimicrobial peptide| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=820| accessdate = }}
2. ^{{cite journal | vauthors = Zanetti M | title = Cathelicidins, multifunctional peptides of the innate immunity | journal = Journal of Leukocyte Biology | volume = 75 | issue = 1 | pages = 39–48 | date = Jan 2004 | pmid = 12960280 | doi = 10.1189/jlb.0403147 }}
3. ^{{cite journal | vauthors = Reinholz M, Ruzicka T, Schauber J | title = Cathelicidin LL-37: an antimicrobial peptide with a role in inflammatory skin disease | journal = Ann Dermatol | volume = 24 | issue = 2 | pages = 126–35 | year = 2012 | pmid = 22577261 | pmc = 3346901 | doi = 10.5021/ad.2012.24.2.126 | url = }}
4. ^{{cite journal | vauthors = Gombart AF, Bhan I, Borregaard N, Tamez H, Camargo CA, Koeffler HP, Thadhani R | title = Low plasma level of cathelicidin antimicrobial peptide (hCAP18) predicts increased infectious disease mortality in patients undergoing hemodialysis | journal = Clinical Infectious Diseases | volume = 48 | issue = 4 | pages = 418–24 | date = Feb 2009 | pmid = 19133797 | doi = 10.1086/596314 | last5 = Camargo }}
5. ^{{cite journal | vauthors = Zasloff M | title = Antimicrobial peptides of multicellular organisms | journal = Nature | volume = 415 | issue = 6870 | pages = 389–95 | date = Jan 2002 | pmid = 11807545 | doi = 10.1038/415389a }}
6. ^{{cite journal | vauthors = Kamen DL, Tangpricha V | title = Vitamin D and molecular actions on the immune system: modulation of innate and autoimmunity | journal = Journal of Molecular Medicine | volume = 88 | issue = 5 | pages = 441–50 | date = May 2010 | pmid = 20119827 | pmc = 2861286 | doi = 10.1007/s00109-010-0590-9 }}
7. ^{{Cite journal|last=Breij|first=Anna de|last2=Riool|first2=Martijn|last3=Cordfunke|first3=Robert A.|last4=Malanovic|first4=Nermina|last5=Boer|first5=Leonie de|last6=Koning|first6=Roman I.|last7=Ravensbergen|first7=Elisabeth|last8=Franken|first8=Marnix|last9=Heijde|first9=Tobias van der|date=2018-01-10|title=The antimicrobial peptide SAAP-148 combats drug-resistant bacteria and biofilms|journal=Science Translational Medicine|language=en|volume=10|issue=423|pages=eaan4044|doi=10.1126/scitranslmed.aan4044|issn=1946-6234|pmid=29321257}}

Clinical significance

See also

References