| 释义 |
- Function
- Interactions
- References
- Further reading
{{Infobox_gene}}LIM homeobox transcription factor 1, alpha, also known as LMX1A, is a protein which in humans is encoded by the LMX1A gene.[1][2] Function Insulin is produced exclusively by the beta cells in the islets of Langerhans in the pancreas. The level and beta-cell specificity of insulin gene expression are regulated by a set of nuclear genes that bind to specific sequences within the promoter of the insulin gene INS and interact with RNA polymerase to activate or repress transcription. LMX1 is a LIM homeobox transcription factor that binds an A/T-rich sequence in the insulin promoter and stimulates transcription of insulin.[3] Interactions LMX1A has been shown to interact with TCF3[4] and LHX3.[5] References 1. ^{{cite web | title = Entrez Gene: LMX1A LIM homeobox transcription factor 1, alpha| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4009| accessdate = }}
2. ^{{cite journal | vauthors = German MS, Wang J, Fernald AA, Espinosa R, Le Beau MM, Bell GI | title = Localization of the genes encoding two transcription factors, LMX1 and CDX3, regulating insulin gene expression to human chromosomes 1 and 13 | journal = Genomics | volume = 24 | issue = 2 | pages = 403–4 | date = November 1994 | pmid = 7698771 | doi = 10.1006/geno.1994.1639 }}
3. ^{{cite web | title = Entrez Gene: LMX1A | url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4009 | accessdate = }}
4. ^{{cite journal | vauthors = Johnson JD, Zhang W, Rudnick A, Rutter WJ, German MS | title = Transcriptional synergy between LIM-homeodomain proteins and basic helix-loop-helix proteins: the LIM2 domain determines specificity | journal = Mol. Cell. Biol. | volume = 17 | issue = 7 | pages = 3488–96 | date = Jul 1997 | pmid = 9199284 | pmc = 232202 | doi=10.1128/mcb.17.7.3488}}
5. ^{{cite journal | vauthors = Jurata LW, Pfaff SL, Gill GN | title = The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors | journal = J. Biol. Chem. | volume = 273 | issue = 6 | pages = 3152–7 | date = Feb 1998 | pmid = 9452425 | doi = 10.1074/jbc.273.6.3152 }}
Further reading {{refbegin | 2}}- {{cite journal | vauthors = German MS, Wang J, Chadwick RB, Rutter WJ | title = Synergistic activation of the insulin gene by a LIM-homeo domain protein and a basic helix-loop-helix protein: building a functional insulin minienhancer complex | journal = Genes Dev. | volume = 6 | issue = 11 | pages = 2165–76 | year = 1992 | pmid = 1358758 | doi = 10.1101/gad.6.11.2165 }}
- {{cite journal | vauthors = German MS, Wang J, Fernald AA, Espinosa R, Le Beau MM, Bell GI | title = Localization of the genes encoding two transcription factors, LMX1 and CDX3, regulating insulin gene expression to human chromosomes 1 and 13 | journal = Genomics | volume = 24 | issue = 2 | pages = 403–4 | year = 1994 | pmid = 7698771 | doi = 10.1006/geno.1994.1639 }}
- {{cite journal | vauthors = Jurata LW, Gill GN | title = Functional analysis of the nuclear LIM domain interactor NLI | journal = Mol. Cell. Biol. | volume = 17 | issue = 10 | pages = 5688–98 | year = 1997 | pmid = 9315627 | pmc = 232417 | doi = }}
- {{cite journal | vauthors = Iannotti CA, Inoue H, Bernal E, Aoki M, Liu L, Donis-Keller H, German MS, Permutt MA | title = Identification of a human LMX1 (LMX1.1)-related gene, LMX1.2: tissue-specific expression and linkage mapping on chromosome 9 | journal = Genomics | volume = 46 | issue = 3 | pages = 520–4 | year = 1997 | pmid = 9441763 | doi = 10.1006/geno.1997.5075 }}
- {{cite journal | vauthors = Jurata LW, Pfaff SL, Gill GN | title = The nuclear LIM domain interactor NLI mediates homo- and heterodimerization of LIM domain transcription factors | journal = J. Biol. Chem. | volume = 273 | issue = 6 | pages = 3152–7 | year = 1998 | pmid = 9452425 | doi = 10.1074/jbc.273.6.3152 }}
- {{cite journal | vauthors = Thameem F, Wolford JK, Wang J, German MS, Bogardus C, Prochazka M | title = Cloning, expression and genomic structure of human LMX1A, and variant screening in Pima Indians | journal = Gene | volume = 290 | issue = 1-2 | pages = 217–25 | year = 2002 | pmid = 12062816 | doi = 10.1016/S0378-1119(02)00582-6 }}
- {{cite journal | vauthors = Millen KJ, Millonig JH, Hatten ME | title = Roof plate and dorsal spinal cord dl1 interneuron development in the dreher mutant mouse | journal = Dev. Biol. | volume = 270 | issue = 2 | pages = 382–92 | year = 2004 | pmid = 15183721 | doi = 10.1016/j.ydbio.2004.03.008 }}
- {{cite journal | vauthors = Hassel S, Eichner A, Yakymovych M, Hellman U, Knaus P, Souchelnytskyi S | title = Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel electrophoresis and mass spectrometry | journal = Proteomics | volume = 4 | issue = 5 | pages = 1346–58 | year = 2004 | pmid = 15188402 | doi = 10.1002/pmic.200300770 }}
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