| 词条 | Lodenafil |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 451225761 | IUPAC_name = 5-(2-Ethoxy-5- | image = Lodenafil.svg | width = 250 | tradename = Helleva | pregnancy_category = Not for use in women | legal_status = Unscheduled | routes_of_administration = By mouth | bioavailability = | metabolism = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 398507-55-6 | DrugBank = | PubChem = 4742795 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 3929995 | C=23 | H=32 | N=6 | O=5 | S=1 | molecular_weight = 504.602 g/mol | smiles = CCCc1c2c(c(=O)nc([nH]2)c3cc(ccc3OCC)S(=O)(=O)N4CCN(CC4)CCO)n(n1)C | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C23H32N6O5S/c1-4-6-18-20-21(27(3)26-18)23(31)25-22(24-20)17-15-16(7-8-19(17)34-5-2)35(32,33)29-11-9-28(10-12-29)13-14-30/h7-8,15,30H,4-6,9-14H2,1-3H3,(H,24,25,31) | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = NEYKRKVLEWKOBI-UHFFFAOYSA-N }} Lodenafil (also known as hydroxyhomosildenafil, trade name Helleva) is a drug belonging to a class of drugs called PDE5 inhibitor, which many other erectile dysfunction drugs such as sildenafil, tadalafil, and vardenafil also belong to. Like udenafil and avanafil it belongs to a new generation of PDE5 inhibitors. Lodenafil is formulated as a prodrug in the form of the carbonate ester dimer, lodenafil carbonate, which breaks down in the body to form two molecules of the active drug lodenafil. This formulation has higher oral bioavailability than the parent drug.[1] It is manufactured by Cristália Produtos Químicos e Farmacêuticos in Brazil and sold there under the brand-name Helleva.[2] It has undergone Phase III clinical trials,[3][4] but is not yet approved for use in the United States by the U.S. Food and Drug Administration. See also
References1. ^{{cite journal |vauthors=Toque HA, Teixeira CE, Lorenzetti R, Okuyama CE, Antunes E, De Nucci G |title=Pharmacological characterization of a novel phosphodiesterase type 5 (PDE5) inhibitor lodenafil carbonate on human and rabbit corpus cavernosum |journal=European Journal of Pharmacology |volume=591 |issue=1–3 |pages=189–95 |date=September 2008 |pmid=18593576 |doi=10.1016/j.ejphar.2008.06.055 |url=}} {{Sexual dysfunction pharmacotherapies}}{{Phosphodiesterase inhibitors}}{{Piperazines}}{{genito-urinary-drug-stub}}2. ^Cristália {{webarchive|url=https://web.archive.org/web/20150315222530/http://2cristalia.com.br/lerNoticia.php?idN=776 |date=2015-03-15 }} Product page. Retrieved on September 16, 2009. 3. ^{{cite journal |vauthors=Glina S, Toscano I, Gomatzky C, de Góes PM, Júnior AN, Claro JF, Pagani E |title=Efficacy and tolerability of lodenafil carbonate for oral therapy in erectile dysfunction: a phase II clinical trial |journal=The Journal of Sexual Medicine |volume=6 |issue=2 |pages=553–7 |date=February 2009 |pmid=19040623 |doi=10.1111/j.1743-6109.2008.01079.x |url=}} 4. ^{{cite journal |vauthors=Glina S, Fonseca GN, Bertero EB, Damião R, Rocha LC, Jardim CR, Cairoli CE, Teloken C, Torres LO, Faria GE, da Silva MB, Pagani E |title=Efficacy and Tolerability of Lodenafil Carbonate for Oral Therapy of Erectile Dysfunction: A Phase III Clinical Trial |journal=The Journal of Sexual Medicine |volume= 7|issue= 5|pages= 1928–1936|date=February 2010 |pmid=20214718 |doi=10.1111/j.1743-6109.2010.01711.x |url=}} 1 : PDE5 inhibitors |
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