| 词条 | Lopirazepam |
| 释义 |
| IUPAC_name = (RS)-7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-2H-pyrido[3,2-e][1,4]diazepin-2-one | image = Lopirazepam.svg | width = 222 | chirality = Racemic mixture | drug_name = | tradename = | pregnancy_category = D | legal_US = Schedule IV | routes_of_administration = Oral | bioavailability = | metabolism = | elimination_half-life = | excretion = | CAS_number = 42863-81-0 | ATC_prefix = none | PubChem = 68672 | ChemSpiderID = 61926 | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 8PDI6DY6GV | C=14 | H=9 | Cl=2 | N=3 | O=2 | molecular_weight = 322.146 g/mol | smiles = ClC1=CC=CC=C1C2=NC(C(NC3=C2N=C(Cl)C=C3)=O)O }}Lopirazepam (INN)[1] is a short-acting benzodiazepine analog of the pyridodiazepine type (specifically, the pyridodiazepine analog of lorazepam) with anxiolytic and hypnotic properties.[2][3] It has never been marketed.[4] See also
References1. ^US Patent 4008223 {{Benzodiazepines}}{{GABAAR PAMs}}{{sedative-stub}}2. ^{{cite journal |vauthors=Saletu M, Saletu B, Grünberger J, Mader R, Karobath M |title=Clinical symptomatology and computer analyzed EEG before, during and after anxiolytic therapy of alcohol withdrawal patients |journal=Neuropsychobiology |volume=9 |issue=2–3 |pages=119–34 |year=1983 |pmid=6353268 |doi= 10.1159/000117949|url=}} 3. ^{{cite journal |vauthors=Fabian A, Röhmel R, Kubicki S |title=[Changes in the length of sleep cycles during administration of flurazepam and lopirazepam] |language=German |journal=EEG EMG Z Elektroenzephalogr Elektromyogr Verwandte Geb |volume=15 |issue=3 |pages=151–8 |date=September 1984 |pmid=6435999 |doi= |url=}} 4. ^{{cite book |author=David J. Triggle |author2=C. R. Ganellin |author3=F. MacDonald |title=Dictionary of Pharmacological Agents |publisher=Chapman & Hall/CRC |location=Boca Raton |year=1996 |volume=2 |page=1232 |isbn=0-412-46630-9 |url=https://books.google.com/books?id=A0THacd46ZsC&pg=PA1232&lpg=PA1232}} Retrieved on December 31, 2008 through Google Book Search. 7 : Abandoned drugs|Alcohols|Benzodiazepines|Chloroarenes|GABAA receptor positive allosteric modulators|Lactams|Pyridodiazepenes |
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