| Year | Winner | Other nominees | | 2006 | Shakira — "Hips Don't Lie (featuring Wyclef Jean)" | - James Blunt — "You're Beautiful"
- Julieta Venegas — "Me Voy"
- Madonna — "Hung Up"
- Maná — "Labios Compartidos"
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| 2007 | Avril Lavigne — "Girlfriend" | - Enrique Iglesias — "Dímelo"
- Julieta Venegas — "Eres para Mí (featuring Anita Tijoux)"
- Ricky Martin — "Tu Recuerdo (featuring La Mari from Chambao and Tommy Torres)"
- Rihanna — "Umbrella (featuring Jay-Z)"
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| 2008 | Tokio Hotel — "Monsoon" | - Jonas Brothers — "When You Look Me in the Eyes"
- Juanes — "Me Enamora"
- Julieta Venegas — "El Presente"
- Katy Perry — "I Kissed a Girl"
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| 2009 | Lady Gaga — "Poker Face" | - Kings of Leon — "Use Somebody"
- Nelly Furtado — "Manos al Aire"
- Shakira — "Loba"
- Wisin & Yandel — "Abusadora"
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{{PremiosMTVLatinoamérica}}{{DEFAULTSORT:Los Premios MTV Latinoamerica for Song of the Year}}