| 释义 |
- Role in hair growth/loss
- See also
- References
- Further reading
- External links
{{Infobox_gene}}Lysophosphatidic acid receptor 6 also known as LPA6, P2RY5, and GPR87, is a protein that in humans is encoded by the LPAR6 gene.[1][2][3][4] LPA6 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).[4][5]The protein encoded by this gene belongs to the family of G-protein coupled receptors, that are preferentially activated by adenosine and uridine nucleotides. This gene aligns with an internal intron of the retinoblastoma susceptibility gene in the reverse orientation.[6] Role in hair growth/loss In February 2008 researchers at the University of Bonn announced they have found the genetic basis of two distinct forms of inherited hair loss, opening a broad path to treatments for baldness. They found that mutations in the gene P2RY5 causes a rare, inherited form of hair loss called Hypotrichosis simplex. It is the first receptor in humans known to play a role in hair growth. The fact that any receptor plays a specific role in hair growth was previously unknown to scientists and with this new knowledge a focus on finding more of these genes may be able to lead to therapies for many different types of hair loss.[4] See also- Lysophospholipid receptor
- P2Y receptor
References1. ^{{cite journal |vauthors=Adrian K, Bernhard MK, Breitinger HG, Ogilvie A | title = Expression of purinergic receptors (ionotropic P2X1-7 and metabotropic P2Y1-11) during myeloid differentiation of HL60 cells | journal = Biochim Biophys Acta | volume = 1492 | issue = 1 | pages = 127–38 |date=Sep 2000 | pmid = 11004484 | pmc = | doi = 10.1016/S0167-4781(00)00094-4}}
2. ^{{cite journal |vauthors=Ralevic V, Burnstock G | title = Receptors for purines and pyrimidines | journal = Pharmacol Rev | volume = 50 | issue = 3 | pages = 413–92 |date=Nov 1998 | pmid = 9755289 | pmc = | doi = }}
3. ^{{cite journal |vauthors=Yanagida K, Masago K, Nakanishi H, Kihara Y, Hamano F, Tajima Y, Taguchi R, Shimizu T, Ishii S | title = Identification and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA6 | journal = J Biol Chem | volume = 284 | issue = 26 | pages = 17731–41 |date=Jun 2009 | pmid = 19386608 | pmc = 2719412 | doi = 10.1074/jbc.M808506200 }}
4. ^1 {{cite journal |vauthors=Pasternack SM, von Kügelgen I, Aboud KA, Lee YA, Rüschendorf F, Voss K, Hillmer AM, Molderings GJ, Franz T, Ramirez A, Nürnberg P, Nöthen MM, Betz RC | title = G protein-coupled receptor P2Y5 and its ligand LPA are involved in maintenance of human hair growth | journal = Nat. Genet. | volume = 40 | issue = 3 | pages = 329–34 |date=March 2008 | pmid = 18297070 | doi = 10.1038/ng.84 | url = | issn = }}
5. ^{{cite journal |vauthors=Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J |date=January 2010 | title = LPA Receptors: Subtypes and Biological Actions | journal = Annual Review of Pharmacology and Toxicology | volume=50 | issue = 1 | pages = 157–186 | doi = 10.1146/annurev.pharmtox.010909.105753 | pmid=20055701}}
6. ^1 {{cite web | title = Entrez Gene: P2RY5 purinergic receptor P2Y, G-protein coupled, 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10161| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Toguchida J, McGee TL, Paterson JC, etal |title=Complete genomic sequence of the human retinoblastoma susceptibility gene. |journal=Genomics |volume=17 |issue= 3 |pages= 535–43 |year= 1993 |pmid= 7902321 |doi= 10.1006/geno.1993.1368 }}
- {{cite journal |vauthors=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1–2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8 }}
- {{cite journal |vauthors=Herzog H, Darby K, Hort YJ, Shine J |title=Intron 17 of the human retinoblastoma susceptibility gene encodes an actively transcribed G protein-coupled receptor gene. |journal=Genome Res. |volume=6 |issue= 9 |pages= 858–61 |year= 1997 |pmid= 8889552 |doi=10.1101/gr.6.9.858 }}
- {{cite journal |vauthors=Li Q, Schachter JB, Harden TK, Nicholas RA |title=The 6H1 orphan receptor, claimed to be the p2y5 receptor, does not mediate nucleotide-promoted second messenger responses. |journal=Biochem. Biophys. Res. Commun. |volume=236 |issue= 2 |pages= 455–60 |year= 1997 |pmid= 9240460 |doi= 10.1006/bbrc.1997.6984 }}
- {{cite journal |vauthors=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1–2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 | pmc=139241 |doi= 10.1073/pnas.242603899 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
- {{cite journal |vauthors=Dunham A, Matthews LH, Burton J, etal |title=The DNA sequence and analysis of human chromosome 13. |journal=Nature |volume=428 |issue= 6982 |pages= 522–8 |year= 2004 |pmid= 15057823 | pmc=2665288 |doi= 10.1038/nature02379 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 | pmc=528928 |doi= 10.1101/gr.2596504 }}
- {{cite journal |vauthors=Ihara H, Hirukawa K, Goto S, Togari A |title=ATP-stimulated interleukin-6 synthesis through P2Y receptors on human osteoblasts. |journal=Biochem. Biophys. Res. Commun. |volume=326 |issue= 2 |pages= 329–34 |year= 2005 |pmid= 15582581 |doi= 10.1016/j.bbrc.2004.11.037 }}
{{refend}}External links- {{UCSC genome browser|LPAR6}}
- {{UCSC gene details|LPAR6}}
{{NLM content}}{{G protein-coupled receptors}}{{Purinergics}}{{transmembranereceptor-stub}} 1 : G protein-coupled receptors |