| 释义 |
- Function
- References
- Further reading
{{Infobox_gene}}Low-density lipoprotein receptor-related protein 1B is a protein that in humans is encoded by the LRP1B gene.[1][2] Function LRP1B belongs to the LDL receptor gene family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands.[3] References1. ^{{cite journal |vauthors=Liu CX, Musco S, Lisitsina NM, Forgacs E, Minna JD, Lisitsyn NA | title = LRP-DIT, a putative endocytic receptor gene, is frequently inactivated in non-small cell lung cancer cell lines | journal = Cancer Res | volume = 60 | issue = 7 | pages = 1961–7 |date=May 2000 | pmid = 10766186 | pmc = | doi = }}
2. ^{{cite web | title = Entrez Gene: LRP1B low density lipoprotein-related protein 1B (deleted in tumors)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53353| accessdate = }}
3. ^{{cite journal |vauthors=Liu CX, Li Y, Obermoeller-McCormick LM, Schwartz AL, Bu G | title = The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein | journal = J. Biol. Chem. | volume = 276 | issue = 31 | pages = 28889–96 |date=August 2001 | pmid = 11384978 | doi = 10.1074/jbc.M102727200 | url = | issn = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Liu CX, Musco S, Lisitsina NM, etal |title=Genomic organization of a new candidate tumor suppressor gene, LRP1B |journal=Genomics |volume=69 |issue= 2 |pages= 271–4 |year= 2001 |pmid= 11031110 |doi= 10.1006/geno.2000.6331 }}
- {{cite journal |vauthors=Langbein S, Szakacs O, Wilhelm M, etal |title=Alteration of the LRP1B gene region is associated with high grade of urothelial cancer |journal=Lab. Invest. |volume=82 |issue= 5 |pages= 639–43 |year= 2002 |pmid= 12004004 |doi=10.1038/labinvest.3780458 }}
- {{cite journal |vauthors=Li Y, Knisely JM, Lu W, etal |title=Low density lipoprotein (LDL) receptor-related protein 1B impairs urokinase receptor regeneration on the cell surface and inhibits cell migration |journal=J. Biol. Chem. |volume=277 |issue= 44 |pages= 42366–71 |year= 2003 |pmid= 12194987 |doi= 10.1074/jbc.M207705200 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
- {{cite journal |vauthors=Cam JA, Zerbinatti CV, Knisely JM, etal |title=The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production |journal=J. Biol. Chem. |volume=279 |issue= 28 |pages= 29639–46 |year= 2004 |pmid= 15126508 |doi= 10.1074/jbc.M313893200 }}
- {{cite journal |vauthors=Tanaga K, Bujo H, Zhu Y, etal |title=LRP1B attenuates the migration of smooth muscle cells by reducing membrane localization of urokinase and PDGF receptors |journal=Arterioscler. Thromb. Vasc. Biol. |volume=24 |issue= 8 |pages= 1422–8 |year= 2005 |pmid= 15166012 |doi= 10.1161/01.ATV.0000133607.80554.09 }}
- {{cite journal |vauthors=Sonoda I, Imoto I, Inoue J, etal |title=Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma |journal=Cancer Res. |volume=64 |issue= 11 |pages= 3741–7 |year= 2004 |pmid= 15172977 |doi= 10.1158/0008-5472.CAN-04-0172 }}
- {{cite journal |vauthors=Li Y, Lu W, Bu G |title=Striking differences of LDL receptor-related protein 1B expression in mouse and human |journal=Biochem. Biophys. Res. Commun. |volume=333 |issue= 3 |pages= 868–73 |year= 2005 |pmid= 15963947 |doi= 10.1016/j.bbrc.2005.05.170 }}
- {{cite journal |vauthors=Pastrana DV, Hanson AJ, Knisely J, etal |title=LRP 1 B functions as a receptor for Pseudomonas exotoxin |journal=Biochim. Biophys. Acta |volume=1741 |issue= 3 |pages= 234–9 |year= 2006 |pmid= 16095885 |doi= 10.1016/j.bbadis.2005.06.007 }}
- {{cite journal |vauthors=Nakagawa T, Pimkhaokham A, Suzuki E, etal |title=Genetic or epigenetic silencing of low density lipoprotein receptor-related protein 1B expression in oral squamous cell carcinoma |journal=Cancer Sci. |volume=97 |issue= 10 |pages= 1070–4 |year= 2006 |pmid= 16918994 |doi= 10.1111/j.1349-7006.2006.00283.x }}
- {{cite journal |vauthors=Liu CX, Ranganathan S, Robinson S, Strickland DK |title=gamma-Secretase-mediated release of the low density lipoprotein receptor-related protein 1B intracellular domain suppresses anchorage-independent growth of neuroglioma cells |journal=J. Biol. Chem. |volume=282 |issue= 10 |pages= 7504–11 |year= 2007 |pmid= 17227771 |doi= 10.1074/jbc.M608088200 }}
{{refend}}{{Lipoprotein metabolism}}{{gene-2-stub}} |