| 释义 |
- References
- Further reading
{{Infobox_gene}}Leucine-rich repeat-containing protein 4 is a protein that in humans is encoded by the LRRC4 gene.[1][2]{{PBB_Summary
| section_title =
| summary_text = This gene is significantly downregulated in primary brain tumors. The exact function of the protein encoded by this gene is unknown.[2]
}}References1. ^{{cite journal |vauthors=Wang JR, Li XL, Fan SQ, Tan C, Xiang JJ, Tang K, Wang R, Li GY | title = Expression of LRRC4 has the potential to decrease the growth rate and tumorigenesis of glioblastoma cell line U251 | journal = AI Zheng | volume = 22 | issue = 9 | pages = 897–902 |date=Sep 2003 | pmid = 12969517 | pmc = | doi = }}
2. ^1 {{cite web | title = Entrez Gene: LRRC4 leucine rich repeat containing 4| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=64101| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
- {{cite journal |vauthors=Nakashiba T, Ikeda T, Nishimura S, etal |title=Netrin-G1: a novel glycosyl phosphatidylinositol-linked mammalian netrin that is functionally divergent from classical netrins. |journal=J. Neurosci. |volume=20 |issue= 17 |pages= 6540–50 |year= 2000 |pmid= 10964959 |doi= 10.1523/JNEUROSCI.20-17-06540.2000}}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Scherer SW, Cheung J, MacDonald JR, etal |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767–72 |year= 2003 |pmid= 12690205 | pmc=2882961 |doi= 10.1126/science.1083423 }}
- {{cite journal |vauthors=Clark HF, Gurney AL, Abaya E, etal |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 | pmc=403697 }}
- {{cite journal |vauthors=Lin JC, Ho WH, Gurney A, Rosenthal A |title=The netrin-G1 ligand NGL-1 promotes the outgrowth of thalamocortical axons. |journal=Nat. Neurosci. |volume=6 |issue= 12 |pages= 1270–6 |year= 2004 |pmid= 14595443 |doi= 10.1038/nn1148 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Zhang Q, Wang J, Fan S, etal |title=Expression and functional characterization of LRRC4, a novel brain-specific member of the LRR superfamily. |journal=FEBS Lett. |volume=579 |issue= 17 |pages= 3674–82 |year= 2005 |pmid= 15967442 |doi= 10.1016/j.febslet.2005.05.058 }}
- {{cite journal |vauthors=Zhang QH, Wang LL, Cao L, etal |title=Study of a novel brain relatively specific gene LRRC4 involved in glioma tumorigenesis suppression using the Tet-on system. |journal=Acta Biochim. Biophys. Sin. (Shanghai) |volume=37 |issue= 8 |pages= 532–40 |year= 2005 |pmid= 16077900 |doi=10.1111/j.1745-7270.2005.00079.x }}
- {{cite journal |vauthors=Fan SQ, Wang JR, Huang H, etal |title=[Function of a novel brain-specific gene LRRC4] |journal=Zhonghua Zhong Liu Za Zhi |volume=27 |issue= 7 |pages= 393–6 |year= 2007 |pmid= 16188120 |doi= }}
- {{cite journal |vauthors=Zhang QH, Wu MH, Wang LL, etal |title=Profiling of differentially expressed genes in LRRC4 overexpressed glioblastoma cells by cDNA array. |journal=Acta Biochim. Biophys. Sin. (Shanghai) |volume=37 |issue= 10 |pages= 680–7 |year= 2005 |pmid= 16215635 |doi=10.1111/j.1745-7270.2005.00100.x }}
- {{cite journal |vauthors=Wu M, Huang C, Gan K, etal |title=LRRC4, a putative tumor suppressor gene, requires a functional leucine-rich repeat cassette domain to inhibit proliferation of glioma cells in vitro by modulating the extracellular signal-regulated kinase/protein kinase B/nuclear factor-kappaB pathway. |journal=Mol. Biol. Cell |volume=17 |issue= 8 |pages= 3534–42 |year= 2006 |pmid= 16723503 |doi= 10.1091/mbc.E05-11-1082 | pmc=1525233 }}
- {{cite journal |vauthors=Wu M, Gan K, Huang C, etal |title=LRRC4 controls in vitro invasion of glioblastoma cells through inhibiting RPTP-zeta expression. |journal=J. Neurooncol. |volume=80 |issue= 2 |pages= 133–42 |year= 2007 |pmid= 16941076 |doi= 10.1007/s11060-006-9173-6 }}
- {{cite journal |vauthors=Wu M, Huang C, Li X, etal |title=LRRC4 inhibits glioblastoma cell proliferation, migration, and angiogenesis by downregulating pleiotropic cytokine expression and responses. |journal=J. Cell. Physiol. |volume=214 |issue= 1 |pages= 65–74 |year= 2007 |pmid= 17541939 |doi= 10.1002/jcp.21163 }}
{{refend}}{{PDB Gallery|geneid=64101}}{{gene-7-stub}} 1 : LRR proteins |