| 词条 | LY-307,452 |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 424946645 | IUPAC_name = (2S,4S)-2-amino-4-(4,4-diphenylbut-1-yl)pentan-1,5-dioic acid | image = LY-307,452.svg | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | IUPHAR_ligand = 3350 | CAS_number = | ATC_prefix = | ATC_suffix = | PubChem = 6324634 | DrugBank = | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 4884363 | C=21 | H=25 | N=1 | O=4 | molecular_weight = 355.428 g/mol | smiles = C1=CC=C(C=C1)C(CCC[C@@H](C[C@@H](C(=O)O)N)C(=O)O)C2=CC=CC=C2 | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C21H25NO4/c22-19(21(25)26)14-17(20(23)24)12-7-13-18(15-8-3-1-4-9-15)16-10-5-2-6-11-16/h1-6,8-11,17-19H,7,12-14,22H2,(H,23,24)(H,25,26)/t17-,19-/m0/s1 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = DWLOVDOPFJPWNE-HKUYNNGSSA-N }} LY-307,452 is a drug used in neuroscience research, which was among the first compounds found that acts as a selective antagonist for the group II metabotropic glutamate receptors (mGluR2/3),[1] and was useful in early studies of this receptor family,[2][3] although it has largely been replaced by newer drugs such as LY-341,495. References1. ^{{cite journal |vauthors=Wermuth CG, Mann A, Schoenfelder A, Wright RA, Johnson BG, Burnett JP, Mayne NG, Schoepp DD |title=(2S,4S)-2-amino-4-(4,4-diphenylbut-1-yl)-pentane-1,5-dioic acid: a potent and selective antagonist for metabotropic glutamate receptors negatively linked to adenylate cyclase |journal=Journal of Medicinal Chemistry |volume=39 |issue=4 |pages=814–6 |date=February 1996 |pmid=8632404 |doi=10.1021/jm9508144 |url=}} {{Metabotropic glutamate receptor modulators}}{{nervous-system-drug-stub}}2. ^{{cite journal |vauthors=Li XC, Beart PM, Monn JA, Jones NM, Widdop RE |title=Type I and II metabotropic glutamate receptor agonists and antagonists evoke cardiovascular effects after intrathecal administration in conscious rats |journal=British Journal of Pharmacology |volume=128 |issue=3 |pages=823–9 |date=October 1999 |pmid=10516668 |pmc=1571690 |doi=10.1038/sj.bjp.0702850 |url=}} 3. ^{{cite journal |vauthors=Sung KW, Choi S, Lovinger DM |title=Activation of group I mGluRs is necessary for induction of long-term depression at striatal synapses |journal=Journal of Neurophysiology |volume=86 |issue=5 |pages=2405–12 |date=November 2001 |pmid=11698530 |doi= |url=}} 3 : Eli Lilly and Company|MGlu2 receptor antagonists|MGlu3 receptor antagonists |
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