| 词条 | Lysidine (nucleoside) |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 455181097 | ImageFile = lysidine.svg | ImageSize = 240px | IUPACName = 2-Amino-6-[4-amino-1-(3,4-dihydroxy-5-hydroxymethyloxolan-2-yl)-1H-pyrimidin-2-ylideneamino]hexanoic acid | OtherNames = 4-Amino-2-(N(6)-lysino)-1-ribofuranosylpyrimidine |Section1={{Chembox Identifiers | CASNo_Ref = {{cascite|correct|??}} | CASNo = 144796-96-3 | PubChem = 44124149 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 24604124 | SMILES = OC[C@H]1O[C@@H](N2C=CC(N)=N/C2=N\\CCCC[C@H](N)C(O)=O)[C@H](O)[C@@H]1O | InChI = 1S/C15H25N5O6/c16-8(14(24)25)3-1-2-5-18-15-19-10(17)4-6-20(15)13-12(23)11(22)9(7-21)26-13/h4,6,8-9,11-13,21-23H,1-3,5,7,16H2,(H,24,25)(H2,17,18,19)/t8-,9+,11+,12+,13+/m0/s1 | InChIKey = MDWUIKMWKDMPDE-IINAIABHSA-N }} |Section2={{Chembox Properties | Formula = C15H25N5O6 | MolarMass = 371.39 g/mol | Appearance = | Density = | MeltingPt = | BoilingPt = | Solubility = }} |Section3={{Chembox Hazards | MainHazards = | FlashPt = | AutoignitionPt = }} }}Lysidine is an uncommon nucleoside, rarely seen outside of tRNA. It is a derivative of cytidine in which the carbonyl is replaced by the amino acid lysine. The third position in the anti-codon of the Isoleucine-specific tRNA, is typically changed from a cytidine which would pair with guanosine to a lysidine which will base pair with adenosine. Uridine could not be used at this position even though it is a conventional partner for adenosine since it will also "wobble base pair" with guanosine. So lysidine allows better translation fidelity.[1][2] References1. ^{{cite journal |title=Structural basis for lysidine formation by ATP pyrophosphatase accompanied by a lysine-specific loop and a tRNA-recognition domain |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue=21 |pages=7487–7492 |date=May 2005 |pmid=15894617 |pmc=1140429 |doi=10.1073/pnas.0501003102 |url= |display-authors=3 |author1=Nakanishi K |author2=Fukai S |author3=Ikeuchi Y |name-list-format=vanc |last4=Soma |first4=A |last5=Sekine |first5=Y |last6=Suzuki |first6=T |last7=Nureki |first7=O}} 2. ^{{cite journal|journal=J Biol Chem|title=The Catalytic Flexibility of tRNAIle-lysidine Synthetase Can Generate Alternative tRNA Substrates for Isoleucyl-tRNA Synthetase |date= Apr 10, 2009| volume=284| issue=15|vauthors=Salowe SP, Wiltsie J, Hawkins JC, Sonatore LM | pages=9656–9662|pmid=19233850|doi=10.1074/jbc.M809013200|pmc=2665086}} 2 : Nucleosides|Pyrimidines |
| 随便看 |
|
开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。