| 词条 | Maitansine |
| 释义 |
| Verifiedfields = changed | verifiedrevid = 387461214 | ImageFile=Maitansine2DCSD.svg | ImageSize=200px | IUPACName= | OtherNames=Maytansin |Section1={{Chembox Identifiers | CASNo_Ref = {{cascite|correct|??}} | CASNo=35846-53-8 | PubChem=5281828 | ChEBI_Ref = {{ebicite|changed|EBI}} | ChEBI = 6701 | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 488931 | UNII_Ref = {{fdacite|changed|FDA}} | UNII = 14083FR882 | SMILES=C/C(CC1=CC(OC)=C(Cl)C(N3C)=C1)=C\\C=C\\[C@@H](OC)[C@@]2(O)C[C@]([C@@H](C)[C@H]4[C@](O4)(C)[C@@H](OC([C@H](C)N(C)C(C)=O)=O)CC3=O)([H])OC(N2)=O | ChemSpiderID = 10274768 | StdInChI = 1S/C34H46ClN3O10/c1-18-11-10-12-26(45-9)34(43)17-25(46-32(42)36-34)19(2)30-33(5,48-30)27(47-31(41)20(3)37(6)21(4)39)16-28(40)38(7)23-14-22(13-18)15-24(44-8)29(23)35/h10-12,14-15,19-20,25-27,30,43H,13,16-17H2,1-9H3,(H,36,42)/b12-10+,18-11+/t19-,20+,25+,26-,27+,30+,33+,34+/m1/s1 | StdInChIKey = WKPWGQKGSOKKOO-RSFHAFMBSA-N |Section2={{Chembox Properties | Formula=C34H46ClN3O10 | MolarMass=692.20 g/mol | Appearance= | Density= | MeltingPt= | BoilingPt= | Solubility= |Section3={{Chembox Hazards | MainHazards= | FlashPt= | AutoignitionPt = }}Maitansine (INN), or maytansine (USAN), is a cytotoxic agent. It inhibits the assembly of microtubules by binding to tubulin at the rhizoxin binding site.[1] It is a macrolide of the ansamycin type and can be isolated from plants of the genus Maytenus.[1] Derivatives are known as maytansinoids.[2] See also
References1. ^1 National Cancer Institute: Definition of Maytansine {{organic-compound-stub}}2. ^{{cite journal | last1 = Yu | first1 = T.-W. | last2 = Bai | first2 = L | last3 = Clade | first3 = D | last4 = Hoffmann | first4 = D | last5 = Toelzer | first5 = S | last6 = Trinh | first6 = KQ | last7 = Xu | first7 = J | last8 = Moss | first8 = SJ | last9 = Leistner | first9 = E | title = The biosynthetic gene cluster of the maytansinoid antitumor agent ansamitocin from Actinosynnemapretiosum | journal = Proceedings of the National Academy of Sciences | volume = 99 | issue = 12 | pages = 7968–7973 | year = 2002 | pmid = 12060743 | pmc = 123004 | doi = 10.1073/pnas.092697199 }} 8 : Ansamycins|Epoxides|Halogen-containing natural products|Lactams|Chloroarenes|Acetamides|Microtubule inhibitors|Carbamates |
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