| 词条 | Malcolm Casadaban |
| 释义 |
| name = Malcolm John Casadaban | image = | caption = | birth_date = {{birth date|1949|8|12}} | birth_place = New Orleans, Louisiana, U.S.A. | death_date = {{death date and age|2009|9|13|1949|8|12}} | death_place = Chicago, Illinois, U.S.A. | occupation = Genetic and Cell Biology Professor | known_for = Death caused by plague }}Malcolm Casadaban (12 August 1949 – 13 September 2009) was Associate Professor of Molecular Genetics and Cell Biology and of Microbiology at the University of Chicago.[1] Casadaban died following an accidental laboratory exposure to an attenuated strain of Yersinia pestis, a bacterium that causes the plague.[2][3] According to a CDC report on the incident, the strain that killed Casadaban (KIM D27) had never been known to infect laboratory workers as it was an "attenuated" or weakened strain that had defective genes for iron uptake. On autopsy, Casadaban was found to have undiagnosed hereditary hemochromatosis (iron overload) which likely played a role in his death.[4] After receiving degrees at MIT and Harvard University, he became Assistant Professor at Chicago in 1980, and Associate Professor in 1985. He had also been associated with Thermogen, a company he formed with two of his former graduate students in 1998, to commercialize his work with thermophilic bacteria. The company expanded to an annual revenue of about $2 million, but was sold to MediChem, in 2000; this company in turn was later purchased by DeCODE Genetics. He had 17 scientific publications cited over 100 times. References1. ^{{cite web| title = Malcolm Casadaban, molecular genetics specialist, 1949-2009 | url = https://news.uchicago.edu/news.php?asset_id=1716 | work = uchicago.edu | date = 2009-09-25 | accessdate = 2009-10-04}} {{DEFAULTSORT:Casadaban, Malcolm}}{{US-scientist-stub}}2. ^{{cite web| title = CDPH: Plague death not a threat to public health | url = http://www.chicagobreakingnews.com/2009/09/yersenia-pestis-malcolm-j-casadaban-university-of-chicago-medical-center-genetics-research-antibioti.html | work = chicagobreakingnews.com | date = 2009-09-20 | accessdate = 2009-10-04}} 3. ^[https://www.bloomberg.com/news/2011-02-25/plague-kills-u-s-scientist-in-first-laboratory-case-in-50-years-cdc-says.html Plague Death Came Within Hours, Spurred by Scientist's Medical Condition], Bloomberg News, Feb 25, 2011 4. ^{{cite web|url=https://www.cdc.gov/mmwr/preview/mmwrhtml/mm6007a1.htm|title=Fatal Laboratory-Acquired Infection with an Attenuated Yersinia pestis Strain --- Chicago, Illinois, 2009, MMWR, 60(07);201-205 (February 25, 2011)|accessdate=2011-02-25}} 6 : 1949 births|2009 deaths|University of Chicago faculty|Harvard University alumni|Massachusetts Institute of Technology alumni|21st-century deaths from plague (disease) |
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