| 释义 |
- Function
- References
- Further reading
{{Infobox_gene}}Alpha-mannosidase 2 is an enzyme that in humans is encoded by the MAN2A1 gene.[1][2][3] Function This gene encodes a protein which is a member of family 38 of the glycosyl hydrolases. The protein is located in the Golgi apparatus and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-linked glycosylation) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus.[3] References 1. ^{{cite journal | vauthors = Moremen KW, Robbins PW | title = Isolation, characterization, and expression of cDNAs encoding murine alpha-mannosidase II, a Golgi enzyme that controls conversion of high mannose to complex N-glycans | journal = The Journal of Cell Biology | volume = 115 | issue = 6 | pages = 1521–34 | date = Dec 1991 | pmid = 1757461 | pmc = 2289207 | doi = 10.1083/jcb.115.6.1521 }}
2. ^{{cite journal | vauthors = Oka T, Ungar D, Hughson FM, Krieger M | title = The COG and COPI complexes interact to control the abundance of GEARs, a subset of Golgi integral membrane proteins | journal = Molecular Biology of the Cell | volume = 15 | issue = 5 | pages = 2423–35 | date = May 2004 | pmid = 15004235 | pmc = 404034 | doi = 10.1091/mbc.E03-09-0699 }}
3. ^1 {{cite web | title = Entrez Gene: MAN2A1 mannosidase, alpha, class 2A, member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4124| accessdate = }}
{{-}} Further reading {{refbegin|33em}}- {{cite journal | vauthors = Land A, Braakman I | title = Folding of the human immunodeficiency virus type 1 envelope glycoprotein in the endoplasmic reticulum | journal = Biochimie | volume = 83 | issue = 8 | pages = 783–90 | date = Aug 2001 | pmid = 11530211 | doi = 10.1016/S0300-9084(01)01314-1 }}
- {{cite journal | vauthors = Dedera DA, Gu RL, Ratner L | title = Role of asparagine-linked glycosylation in human immunodeficiency virus type 1 transmembrane envelope function | journal = Virology | volume = 187 | issue = 1 | pages = 377–82 | date = Mar 1992 | pmid = 1736542 | doi = 10.1016/0042-6822(92)90331-I }}
- {{cite journal | vauthors = Moremen KW, Touster O, Robbins PW | title = Novel purification of the catalytic domain of Golgi alpha-mannosidase II. Characterization and comparison with the intact enzyme | journal = The Journal of Biological Chemistry | volume = 266 | issue = 25 | pages = 16876–85 | date = Sep 1991 | pmid = 1885615 | doi = | authorlink2 = Oscar Touster }}
- {{cite journal | vauthors = Kalyanaraman VS, Rodriguez V, Veronese F, Rahman R, Lusso P, DeVico AL, Copeland T, Oroszlan S, Gallo RC, Sarngadharan MG | title = Characterization of the secreted, native gp120 and gp160 of the human immunodeficiency virus type 1 | journal = AIDS Research and Human Retroviruses | volume = 6 | issue = 3 | pages = 371–80 | date = Mar 1990 | pmid = 2187500 | doi = 10.1089/aid.1990.6.371 }}
- {{cite journal | vauthors = Shimizu H, Tsuchie H, Honma H, Yoshida K, Tsuruoka T, Ushijima H, Kitamura T | title = Effect of N-(3-phenyl-2-propenyl)-1-deoxynojirimycin on the lectin binding to HIV-1 glycoproteins | journal = Japanese Journal of Medical Science & Biology | volume = 43 | issue = 3 | pages = 75–87 | date = Jun 1990 | pmid = 2283726 | doi = 10.7883/yoken1952.43.75 }}
- {{cite journal | vauthors = Leonard CK, Spellman MW, Riddle L, Harris RJ, Thomas JN, Gregory TJ | title = Assignment of intrachain disulfide bonds and characterization of potential glycosylation sites of the type 1 recombinant human immunodeficiency virus envelope glycoprotein (gp120) expressed in Chinese hamster ovary cells | journal = The Journal of Biological Chemistry | volume = 265 | issue = 18 | pages = 10373–82 | date = Jun 1990 | pmid = 2355006 | doi = }}
- {{cite journal | vauthors = Pal R, Hoke GM, Sarngadharan MG | title = Role of oligosaccharides in the processing and maturation of envelope glycoproteins of human immunodeficiency virus type 1 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 86 | issue = 9 | pages = 3384–8 | date = May 1989 | pmid = 2541446 | pmc = 287137 | doi = 10.1073/pnas.86.9.3384 }}
- {{cite journal | vauthors = Dewar RL, Vasudevachari MB, Natarajan V, Salzman NP | title = Biosynthesis and processing of human immunodeficiency virus type 1 envelope glycoproteins: effects of monensin on glycosylation and transport | journal = Journal of Virology | volume = 63 | issue = 6 | pages = 2452–6 | date = Jun 1989 | pmid = 2542563 | pmc = 250699 | doi = }}
- {{cite journal | vauthors = Kozarsky K, Penman M, Basiripour L, Haseltine W, Sodroski J, Krieger M | title = Glycosylation and processing of the human immunodeficiency virus type 1 envelope protein | journal = Journal of Acquired Immune Deficiency Syndromes | volume = 2 | issue = 2 | pages = 163–9 | year = 1989 | pmid = 2649653 | doi = }}
- {{cite journal | vauthors = Robinson WE, Montefiori DC, Mitchell WM | title = Evidence that mannosyl residues are involved in human immunodeficiency virus type 1 (HIV-1) pathogenesis | journal = AIDS Research and Human Retroviruses | volume = 3 | issue = 3 | pages = 265–82 | year = 1988 | pmid = 2829950 | doi = 10.1089/aid.1987.3.265 }}
- {{cite journal | vauthors = Blough HA, Pauwels R, De Clercq E, Cogniaux J, Sprecher-Goldberger S, Thiry L | title = Glycosylation inhibitors block the expression of LAV/HTLV-III (HIV) glycoproteins | journal = Biochemical and Biophysical Research Communications | volume = 141 | issue = 1 | pages = 33–8 | date = Nov 1986 | pmid = 3099781 | doi = 10.1016/S0006-291X(86)80330-8 }}
- {{cite journal | vauthors = Montefiori DC, Robinson WE, Mitchell WM | title = Role of protein N-glycosylation in pathogenesis of human immunodeficiency virus type 1 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 85 | issue = 23 | pages = 9248–52 | date = Dec 1988 | pmid = 3264072 | pmc = 282716 | doi = 10.1073/pnas.85.23.9248 }}
- {{cite journal | vauthors = Moremen KW, Touster O | title = Biosynthesis and modification of Golgi mannosidase II in HeLa and 3T3 cells | journal = The Journal of Biological Chemistry | volume = 260 | issue = 11 | pages = 6654–62 | date = Jun 1985 | pmid = 3922977 | doi = }}
- {{cite journal | vauthors = Fenouillet E, Jones I, Powell B, Schmitt D, Kieny MP, Gluckman JC | title = Functional role of the glycan cluster of the human immunodeficiency virus type 1 transmembrane glycoprotein (gp41) ectodomain | journal = Journal of Virology | volume = 67 | issue = 1 | pages = 150–60 | date = Jan 1993 | pmid = 8093218 | pmc = 237347 | doi = }}
- {{cite journal | vauthors = Yeh JC, Seals JR, Murphy CI, van Halbeek H, Cummings RD | title = Site-specific N-glycosylation and oligosaccharide structures of recombinant HIV-1 gp120 derived from a baculovirus expression system | journal = Biochemistry | volume = 32 | issue = 41 | pages = 11087–99 | date = Oct 1993 | pmid = 8218172 | doi = 10.1021/bi00092a019 }}
- {{cite journal | vauthors = Velasco A, Hendricks L, Moremen KW, Tulsiani DR, Touster O, Farquhar MG | title = Cell type-dependent variations in the subcellular distribution of alpha-mannosidase I and II | journal = The Journal of Cell Biology | volume = 122 | issue = 1 | pages = 39–51 | date = Jul 1993 | pmid = 8314846 | pmc = 2119607 | doi = 10.1083/jcb.122.1.39 }}
- {{cite journal | vauthors = Misago M, Liao YF, Kudo S, Eto S, Mattei MG, Moremen KW, Fukuda MN | title = Molecular cloning and expression of cDNAs encoding human alpha-mannosidase II and a previously unrecognized alpha-mannosidase IIx isozyme | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 92 | issue = 25 | pages = 11766–70 | date = Dec 1995 | pmid = 8524845 | pmc = 40483 | doi = 10.1073/pnas.92.25.11766 }}
- {{cite journal | vauthors = Bolmstedt A, Sjölander S, Hansen JE, Akerblom L, Hemming A, Hu SL, Morein B, Olofsson S | title = Influence of N-linked glycans in V4-V5 region of human immunodeficiency virus type 1 glycoprotein gp160 on induction of a virus-neutralizing humoral response | journal = Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology | volume = 12 | issue = 3 | pages = 213–20 | date = Jul 1996 | pmid = 8673525 | doi = 10.1097/00042560-199607000-00001 }}
- {{cite journal | vauthors = Hu H, Shioda T, Moriya C, Xin X, Hasan MK, Miyake K, Shimada T, Nagai Y | title = Infectivities of human and other primate lentiviruses are activated by desialylation of the virion surface | journal = Journal of Virology | volume = 70 | issue = 11 | pages = 7462–70 | date = Nov 1996 | pmid = 8892864 | pmc = 190813 | doi = }}
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