| 词条 | Mannosulfan |
| 释义 |
| verifiedrevid = 444359259 | IUPAC_name = 1,2,5,6-Tetrakis-O-(methylsulfonyl)-D-mannitol | image = Mannosulfan.png | tradename = | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number = | ATC_prefix = L01 | ATC_suffix = AB03 | ATC_supplemental = | PubChem = 24140 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 135FQ40L36 | ChemSpiderID = 16736959 | chemical_formula = | C=10 | H=22 | O=14 | S=4 | molecular_weight = 494.53 g/mol | smiles = CS(=O)(=O)OC[C@H]([C@H]([C@@H]([C@@H](COS(=O)(=O)C)OS(=O)(=O)C)O)O)OS(=O)(=O)C | synonyms = [(2R,3S,4S,5R)-3,4-dihydroxy-2,5,6-tris(methylsulfonyloxy)hexyl] methanesulfonate | StdInChI = 1S/C10H22O14S4/c1-25(13,14)21-5-7(23-27(3,17)18)9(11)10(12)8(24-28(4,19)20)6-22-26(2,15)16/h7-12H,5-6H2,1-4H3/t7-,8-,9-,10-/m1/s1 | StdInChIKey = UUVIQYKKKBJYJT-ZYUZMQFOSA-N}}Mannosulfan (INN) is an alkylating agent with potential for treatment of cancer. It is not approved by the United States FDA for cancer treatment. Research suggests it is less toxic than the alkyl sulfonate Busulfan.[1] References1. ^{{Cite book|doi=10.1016/B978-0-323-52727-9.00015-7 |chapter=Recent Advances in the Delivery of Chemotherapeutic Agents |title=Nano- and Microscale Drug Delivery Systems |pages=281–98 |year=2017 |last1=Jeswani |first1=Gunjan |last2=Paul |first2=Swarnali D |isbn=978-0-323-52727-9 }} External links
4 : Sulfonate esters|Monosaccharides|Alkylating antineoplastic agents|Sugar alcohols |
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