“Mannotetraose 2-alpha-N-acetylglucosaminyltransferase”的意思、由来-开放百科全书

词条

Mannotetraose 2-alpha-N-acetylglucosaminyltransferase

释义

References

{{enzyme
| Name = mannotetraose 2-alpha-N-acetylglucosaminyltransferase
| EC_number = 2.4.1.138
| CAS_number = 81032-47-5
| IUBMB_EC_number = 2/4/1/138
| GO_code = 0047222
| image =
| width =
| caption =
}}

In enzymology, a mannotetraose 2-alpha-N-acetylglucosaminyltransferase ({{EC number|2.4.1.138}}) is an enzyme that catalyzes the chemical reaction

UDP-N-acetyl-D-glucosamine + 1,3-alpha-D-mannosyl-1,2-alpha-D-mannosyl-1,2-alpha-D-mannosyl-D-mannose UDP + 1,3-alpha-D-mannosyl-1,2-(N-acetyl-alpha-D-glucosaminyl-alpha-D-mannosyl)-1,2-alpha-D-mannosyl-D-mannose

The 2 substrates of this enzyme are UDP-N-acetyl-D-glucosamine and 1,3-alpha-D-mannosyl-1,2-alpha-D-mannosyl-1,2-alpha-D-mannosyl-D-mannose, whereas its 2 products are UDP and 1,3-alpha-D-mannosyl-1,2-(N-acetyl-alpha-D-glucosaminyl-alpha-D-mannosyl)-1,2-alpha-D-mannosyl-D-mannose.

This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is UDP-N-acetyl-D-glucosamine:mannotetraose alpha-N-acetyl-D-glucosaminyltransferase. Other names in common use include alpha-N-acetylglucosaminyltransferase, uridine diphosphoacetylglucosamine mannoside, and alpha1->2-alphacetylglucosaminyltransferase.

References

{{cite journal | vauthors = Douglas RH, Ballou CE | date = 1982 | title = Purification of an alpha-N-acetylglucosaminyltransferase from the yeast Kluyveromyces lactis and a study of mutants defective in this enzyme activity | journal = Biochemistry | volume = 21 | pages = 1561–70 | pmid = 6211189 | doi = 10.1021/bi00536a015 | issue = 7 }}

2 : EC 2.4.1|Enzymes of unknown structure

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