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词条 MAP3K14
释义

  1. Function

  2. Interactions

  3. References

  4. Further reading

{{Infobox_gene}}Mitogen-activated protein kinase kinase kinase 14 also known as NF-kappa-B-inducing kinase (NIK) is an enzyme that in humans is encoded by the MAP3K14 gene.[1][2]

Function

This gene encodes mitogen-activated protein kinase kinase kinase 14, NIK, which is a serine/threonine protein-kinase. This kinase binds to TRAF2 and stimulates NF-κB activity. It is a critical kinase of the alternative NF-κB activation pathway. It shares sequence similarity with several other MAPKK kinases. It participates in an NF-κB-inducing signalling cascade common to receptors of the tumour-necrosis/nerve-growth factor (TNF/NGF) family and to the interleukin-1 type-I receptor.[2]

Interactions

MAP3K14 has been shown to interact with:

  • CHUK,[4][3][4][5]
  • IKK2,[4][6] and
  • TRAF2.[1][7]

References

1. ^1 {{cite journal | vauthors = Malinin NL, Boldin MP, Kovalenko AV, Wallach D | title = MAP3K-related kinase involved in NF-kappaB induction by TNF, CD95 and IL-1 | journal = Nature | volume = 385 | issue = 6616 | pages = 540–4 | date = March 1997 | pmid = 9020361 | pmc = | doi = 10.1038/385540a0 }}
2. ^1 {{cite web | title = Entrez Gene: MAP3K14 mitogen-activated protein ki kinase kinase 14| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9020| accessdate = }}
3. ^{{cite journal | vauthors = Régnier CH, Song HY, Gao X, Goeddel DV, Cao Z, Rothe M | title = Identification and characterization of an IkappaB kinase | journal = Cell | volume = 90 | issue = 2 | pages = 373–83 | date = July 1997 | pmid = 9244310 | doi = 10.1016/S0092-8674(00)80344-X}}
4. ^{{cite journal | vauthors = Xiao G, Sun SC | title = Negative regulation of the nuclear factor kappa B-inducing kinase by a cis-acting domain | journal = J. Biol. Chem. | volume = 275 | issue = 28 | pages = 21081–5 | date = July 2000 | pmid = 10887201 | doi = 10.1074/jbc.M002552200 }}
5. ^{{cite journal | vauthors = Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K | title = The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway | journal = Nature | volume = 398 | issue = 6724 | pages = 252–6 | date = March 1999 | pmid = 10094049 | doi = 10.1038/18465 }}
6. ^{{cite journal | vauthors = Woronicz JD, Gao X, Cao Z, Rothe M, Goeddel DV | title = IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK | journal = Science | volume = 278 | issue = 5339 | pages = 866–9 | date = October 1997 | pmid = 9346485 | doi = 10.1126/science.278.5339.866}}
7. ^1 2 {{cite journal | vauthors = Luftig MA, Cahir-McFarland E, Mosialos G, Kieff E | title = Effects of the NIK aly mutation on NF-kappaB activation by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40 | journal = J. Biol. Chem. | volume = 276 | issue = 18 | pages = 14602–6 | date = May 2001 | pmid = 11278268 | doi = 10.1074/jbc.C100103200 }}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Régnier CH, Song HY, Gao X, Goeddel DV, Cao Z, Rothe M | title = Identification and characterization of an IkappaB kinase | journal = Cell | volume = 90 | issue = 2 | pages = 373–83 | year = 1997 | pmid = 9244310 | doi = 10.1016/S0092-8674(00)80344-X }}
  • {{cite journal | vauthors = Song HY, Régnier CH, Kirschning CJ, Goeddel DV, Rothe M | title = Tumor necrosis factor (TNF)-mediated kinase cascades: Bifurcation of Nuclear Factor-κB and c-jun N-terminal kinase (JNK/SAPK) pathways at TNF receptor-associated factor 2 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 94 | issue = 18 | pages = 9792–6 | year = 1997 | pmid = 9275204 | pmc = 23270 | doi = 10.1073/pnas.94.18.9792 }}
  • {{cite journal | vauthors = Woronicz JD, Gao X, Cao Z, Rothe M, Goeddel DV | title = IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK | journal = Science | volume = 278 | issue = 5339 | pages = 866–9 | year = 1997 | pmid = 9346485 | doi = 10.1126/science.278.5339.866 }}
  • {{cite journal | vauthors = Ling L, Cao Z, Goeddel DV | title = NF-κB-inducing kinase activates IKK-α by phosphorylation of Ser-176 | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 7 | pages = 3792–7 | year = 1998 | pmid = 9520446 | pmc = 19916 | doi = 10.1073/pnas.95.7.3792 }}
  • {{cite journal | vauthors = Lee FS, Peters RT, Dang LC, Maniatis T | title = MEKK1 activates both IκB kinase α and IκB kinase β | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 95 | issue = 16 | pages = 9319–24 | year = 1998 | pmid = 9689078 | pmc = 21336 | doi = 10.1073/pnas.95.16.9319 }}
  • {{cite journal | vauthors = Lin X, Mu Y, Cunningham ET, Marcu KB, Geleziunas R, Greene WC | title = Molecular Determinants of NF-κB-Inducing Kinase Action | journal = Mol. Cell. Biol. | volume = 18 | issue = 10 | pages = 5899–907 | year = 1998 | pmid = 9742107 | pmc = 109176 | doi = 10.1128/mcb.18.10.5899}}
  • {{cite journal | vauthors = Cohen L, Henzel WJ, Baeuerle PA | title = IKAP is a scaffold protein of the IkappaB kinase complex | journal = Nature | volume = 395 | issue = 6699 | pages = 292–6 | year = 1998 | pmid = 9751059 | doi = 10.1038/26254 }}
  • {{cite journal | vauthors = Aronsson FC, Magnusson P, Andersson B, Karsten SL, Shibasaki Y, Lendon CL, Goate AM, Brookes AJ | title = The NIK protein kinase and C17orf1 genes: chromosomal mapping, gene structures and mutational screening in frontotemporal dementia and parkinsonism linked to chromosome 17 | journal = Hum. Genet. | volume = 103 | issue = 3 | pages = 340–5 | year = 1998 | pmid = 9799091 | doi = 10.1007/s004390050827 }}
  • {{cite journal | vauthors = Nemoto S, DiDonato JA, Lin A | title = Coordinate Regulation of IκB Kinases by Mitogen-Activated Protein Kinase Kinase Kinase 1 and NF-κB-Inducing Kinase | journal = Mol. Cell. Biol. | volume = 18 | issue = 12 | pages = 7336–43 | year = 1998 | pmid = 9819420 | pmc = 109315 | doi = 10.1128/mcb.18.12.7336}}
  • {{cite journal | vauthors = Li Y, Kang J, Friedman J, Tarassishin L, Ye J, Kovalenko A, Wallach D, Horwitz MS | title = Identification of a cell protein (FIP-3) as a modulator of NF-κB activity and as a target of an adenovirus inhibitor of tumor necrosis factor α-induced apoptosis | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 96 | issue = 3 | pages = 1042–7 | year = 1999 | pmid = 9927690 | pmc = 15347 | doi = 10.1073/pnas.96.3.1042 }}
  • {{cite journal | vauthors = Lallena MJ, Diaz-Meco MT, Bren G, Payá CV, Moscat J | title = Activation of IκB Kinase β by Protein Kinase C Isoforms | journal = Mol. Cell. Biol. | volume = 19 | issue = 3 | pages = 2180–8 | year = 1999 | pmid = 10022904 | pmc = 84010 | doi = }}
  • {{cite journal | vauthors = Lin X, Cunningham ET, Mu Y, Geleziunas R, Greene WC | title = The proto-oncogene Cot kinase participates in CD3/CD28 induction of NF-kappaB acting through the NF-kappaB-inducing kinase and IkappaB kinases | journal = Immunity | volume = 10 | issue = 2 | pages = 271–80 | year = 1999 | pmid = 10072079 | doi = 10.1016/S1074-7613(00)80027-8 }}
  • {{cite journal | vauthors = Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K | title = The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway | journal = Nature | volume = 398 | issue = 6724 | pages = 252–6 | year = 1999 | pmid = 10094049 | doi = 10.1038/18465 }}
  • {{cite journal | vauthors = Delhase M, Hayakawa M, Chen Y, Karin M | title = Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation | journal = Science | volume = 284 | issue = 5412 | pages = 309–13 | year = 1999 | pmid = 10195894 | doi = 10.1126/science.284.5412.309 }}
  • {{cite journal | vauthors = Hu WH, Johnson H, Shu HB | title = Tumor necrosis factor-related apoptosis-inducing ligand receptors signal NF-kappaB and JNK activation and apoptosis through distinct pathways | journal = J. Biol. Chem. | volume = 274 | issue = 43 | pages = 30603–10 | year = 1999 | pmid = 10521444 | doi = 10.1074/jbc.274.43.30603 }}
  • {{cite journal | vauthors = Yamamoto Y, Yin MJ, Gaynor RB | title = IκB Kinase α (IKKα) Regulation of IKKβ Kinase Activity | journal = Mol. Cell. Biol. | volume = 20 | issue = 10 | pages = 3655–66 | year = 2000 | pmid = 10779355 | pmc = 85658 | doi = 10.1128/MCB.20.10.3655-3666.2000 }}
  • {{cite journal | vauthors = Xiao G, Sun SC | title = Negative regulation of the nuclear factor kappa B-inducing kinase by a cis-acting domain | journal = J. Biol. Chem. | volume = 275 | issue = 28 | pages = 21081–5 | year = 2000 | pmid = 10887201 | doi = 10.1074/jbc.M002552200 }}
  • {{cite journal | vauthors = Chaudhary PM, Eby MT, Jasmin A, Kumar A, Liu L, Hood L | title = Activation of the NF-kappaB pathway by caspase 8 and its homologs | journal = Oncogene | volume = 19 | issue = 39 | pages = 4451–60 | year = 2000 | pmid = 11002417 | doi = 10.1038/sj.onc.1203812 }}
  • {{cite journal | vauthors = Kumar A, Eby MT, Sinha S, Jasmin A, Chaudhary PM | title = The ectodermal dysplasia receptor activates the nuclear factor-kappaB, JNK, and cell death pathways and binds to ectodysplasin A | journal = J. Biol. Chem. | volume = 276 | issue = 4 | pages = 2668–77 | year = 2001 | pmid = 11035039 | doi = 10.1074/jbc.M008356200 }}
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