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词条 MAP3K7IP1
释义

  1. Function

  2. Interactions

  3. References

  4. Further reading

{{Infobox_gene}}Mitogen-activated protein kinase kinase kinase 7-interacting protein 1 is an enzyme that in humans is encoded by the MAP3K7IP1 gene.[1][2][3]

Function

The protein encoded by this gene was identified as a regulator of the MAP kinase kinase kinase MAP3K7/TAK1, which is known to mediate various intracellular signaling pathways, such as those induced by TGF beta, interleukin 1, and WNT-1. This protein interacts and thus activates TAK1 kinase. It has been shown that the C-terminal portion of this protein is sufficient for binding and activation of TAK1, while a portion of the N-terminus acts as a dominant-negative inhibitor of TGF beta, suggesting that this protein may function as a mediator between TGF beta receptors and TAK1. This protein can also interact with and activate the mitogen-activated protein kinase 14 (MAPK14/p38alpha), and thus represents an alternative activation pathway, in addition to the MAPKK pathways, which contributes to the biological responses of MAPK14 to various stimuli. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[3]

This protein plays an important role in skin homeostasis,[4][5] wound repair,[6][7] and oncogenesis.[8]

Interactions

MAP3K7IP1 has been shown to interact with:

{{div col|colwidth=20em}}
  • MAP3K7IP2,[10][9][10]
  • MAP3K7IP3,[10]
  • MAP3K7,[10][15][11][12]
  • MAPK14,[13]
  • Mothers against decapentaplegic homolog 7,[14][15]
  • TRAF6,[16][17][18]
  • XIAP,[19][20] and
  • ZMYND11.[21]
{{Div col end}}

References

1. ^{{cite journal | vauthors = Shibuya H, Yamaguchi K, Shirakabe K, Tonegawa A, Gotoh Y, Ueno N, Irie K, Nishida E, Matsumoto K | title = TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction | journal = Science | volume = 272 | issue = 5265 | pages = 1179–82 | date = July 1996 | pmid = 8638164 | pmc = | doi = 10.1126/science.272.5265.1179 }}
2. ^{{cite journal | vauthors = Sakurai H, Miyoshi H, Toriumi W, Sugita T | title = Functional interactions of transforming growth factor beta-activated kinase 1 with IkappaB kinases to stimulate NF-kappaB activation | journal = J Biol Chem | volume = 274 | issue = 15 | pages = 10641–8 | date = May 1999 | pmid = 10187861 | pmc = | doi = 10.1074/jbc.274.15.10641 }}
3. ^1 {{cite web | title = Entrez Gene: MAP3K7IP1 mitogen-activated protein kinase kinase kinase 7 interacting protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10454| accessdate = }}
4. ^{{cite journal | vauthors = Omori E, Matsumoto K, Sanjo H, Sato S, Akira S, Smart RC, Ninomiya-Tsuji J | title = TAK1 is a master regulator of epidermal homeostasis involving skin inflammation and apoptosis. | journal = J. Biol. Chem. | volume = 281 | issue = 28 | pages = 19610–19617 | date = July 2006 | pmid = 16675448 | pmc = 1797070 | doi = 10.1074/jbc.M603384200 }}
5. ^{{cite journal | vauthors = Sayama K, Hanakawa Y, Nagai H, Shirakata Y, Dai X, Hirakawa S, Tokumaru S, Tohyama M, Yang L, Sato S, Shizuo A, Hashimoto K | title = Transforming growth factor-beta-activated kinase 1 is essential for differentiation and the prevention of apoptosis in epidermis. | journal = J. Biol. Chem. | volume = 281 | issue = 31 | pages = 22013–22020 | date = August 2006 | pmid = 16754690 | doi = 10.1074/jbc.M601065200 }}
6. ^{{cite journal | vauthors = Tan SH, Pal M, Tan MJ, Wong MH, Tam FU, Teo JW, Chong HC, Tan CK, Goh YY, Tang MB, Cheung PC, Tan NS | title = Regulation of cell proliferation and migration by TAK1 via transcriptional control of von Hippel-Lindau tumor suppressor. | journal = J. Biol. Chem. | volume = 284 | issue = 27 | pages = 18047–18058 | date = July 2009 | pmid = 19419968 | pmc = 2709347 | doi = 10.1074/jbc.M109.002691 }}
7. ^{{cite journal | vauthors = Lam CR, Tan MJ, Tan SH, Tang MB, Cheung PC, Tan NS | title = TAK1 regulates SCF expression to modulate PKBα activity that protects keratinocytes from ROS-induced apoptosis. | journal = Cell Death Differ. | volume = 18 | issue = 7 | pages = 1120–9 | date = January 2011 | pmid = 21233843 | doi = 10.1038/cdd.2010.182 | pmc = 3131962 }}
8. ^{{cite journal | vauthors = Omori E, Matsumoto K, Zhu S, Smart RC, Ninomiya-Tsuji J | title = Ablation of TAK1 upregulates reactive oxygen species and selectively kills tumor cells. | journal = Cancer Res. | volume = 70 | issue = 21 | pages = 8417–8425 | date = November 2010 | pmid = 20959492 | pmc = 2970664 | doi = 10.1158/0008-5472.CAN-10-1227 }}
9. ^{{cite journal | vauthors = Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G | title = A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway | journal = Nat. Cell Biol. | volume = 6 | issue = 2 | pages = 97–105 | date = February 2004 | pmid = 14743216 | doi = 10.1038/ncb1086 }}
10. ^1 2 {{cite journal | vauthors = Cheung PC, Nebreda AR, Cohen P | title = TAB3, a new binding partner of the protein kinase TAK1 | journal = Biochem. J. | volume = 378 | issue = Pt 1 | pages = 27–34 | date = February 2004 | pmid = 14670075 | pmc = 1223947 | doi = 10.1042/BJ20031794 }}
11. ^{{cite journal | vauthors = Channavajhala PL, Wu L, Cuozzo JW, Hall JP, Liu W, Lin LL, Zhang Y | title = Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling | journal = J. Biol. Chem. | volume = 278 | issue = 47 | pages = 47089–97 | date = November 2003 | pmid = 12975377 | doi = 10.1074/jbc.M306002200 }}
12. ^{{cite journal | vauthors = Sakurai H, Miyoshi H, Mizukami J, Sugita T | title = Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1 | journal = FEBS Lett. | volume = 474 | issue = 2–3 | pages = 141–5 | date = June 2000 | pmid = 10838074 | doi = 10.1016/s0014-5793(00)01588-x}}
13. ^{{cite journal | vauthors = Ge B, Gram H, Di Padova F, Huang B, New L, Ulevitch RJ, Luo Y, Han J | title = MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha | journal = Science | volume = 295 | issue = 5558 | pages = 1291–4 | date = February 2002 | pmid = 11847341 | doi = 10.1126/science.1067289 }}
14. ^{{cite journal | vauthors = Edlund S, Bu S, Schuster N, Aspenström P, Heuchel R, Heldin NE, ten Dijke P, Heldin CH, Landström M | title = Transforming growth factor-beta1 (TGF-beta)-induced apoptosis of prostate cancer cells involves Smad7-dependent activation of p38 by TGF-beta-activated kinase 1 and mitogen-activated protein kinase kinase 3 | journal = Mol. Biol. Cell | volume = 14 | issue = 2 | pages = 529–44 | date = February 2003 | pmid = 12589052 | pmc = 149990 | doi = 10.1091/mbc.02-03-0037 }}
15. ^{{cite journal | vauthors = Yanagisawa M, Nakashima K, Takeda K, Ochiai W, Takizawa T, Ueno M, Takizawa M, Shibuya H, Taga T | title = Inhibition of BMP2-induced, TAK1 kinase-mediated neurite outgrowth by Smad6 and Smad7 | journal = Genes Cells | volume = 6 | issue = 12 | pages = 1091–9 | date = December 2001 | pmid = 11737269 | doi = 10.1046/j.1365-2443.2001.00483.x}}
16. ^1 {{cite journal | vauthors = Takaesu G, Kishida S, Hiyama A, Yamaguchi K, Shibuya H, Irie K, Ninomiya-Tsuji J, Matsumoto K | title = TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway | journal = Mol. Cell | volume = 5 | issue = 4 | pages = 649–58 | date = April 2000 | pmid = 10882101 | doi = 10.1016/s1097-2765(00)80244-0}}
17. ^1 {{cite journal | vauthors = Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K | title = The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway | journal = Nature | volume = 398 | issue = 6724 | pages = 252–6 | date = March 1999 | pmid = 10094049 | doi = 10.1038/18465 }}
18. ^{{cite journal | vauthors = Walsh MC, Kim GK, Maurizio PL, Molnar EE, Choi Y | title = TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL | journal = PLoS ONE | volume = 3 | issue = 12 | pages = e4064 | pmid = 19112497 | pmc = 2603309 | doi = 10.1371/journal.pone.0004064 | editor1-last = Unutmaz | editor1-first = Derya | year = 2008 }}
19. ^{{cite journal | vauthors = Yamaguchi K, Nagai S, Ninomiya-Tsuji J, Nishita M, Tamai K, Irie K, Ueno N, Nishida E, Shibuya H, Matsumoto K | title = XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway | journal = EMBO J. | volume = 18 | issue = 1 | pages = 179–87 | date = January 1999 | pmid = 9878061 | pmc = 1171113 | doi = 10.1093/emboj/18.1.179 }}
20. ^{{cite journal | vauthors = Sanna MG, da Silva Correia J, Luo Y, Chuang B, Paulson LM, Nguyen B, Deveraux QL, Ulevitch RJ | title = ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis | journal = J. Biol. Chem. | volume = 277 | issue = 34 | pages = 30454–62 | date = August 2002 | pmid = 12048196 | doi = 10.1074/jbc.M203312200 }}
21. ^{{cite journal | vauthors = Kurozumi K, Nishita M, Yamaguchi K, Fujita T, Ueno N, Shibuya H | title = BRAM1, a BMP receptor-associated molecule involved in BMP signalling | journal = Genes Cells | volume = 3 | issue = 4 | pages = 257–64 | date = April 1998 | pmid = 9663660 | doi = 10.1046/j.1365-2443.1998.00186.x}}

Further reading

{{refbegin |35em}}
  • {{cite journal | vauthors = Kurozumi K, Nishita M, Yamaguchi K, Fujita T, Ueno N, Shibuya H | title = BRAM1, a BMP receptor-associated molecule involved in BMP signalling. | journal = Genes Cells | volume = 3 | issue = 4 | pages = 257–64 | year = 1998 | pmid = 9663660 | doi = 10.1046/j.1365-2443.1998.00186.x }}
  • {{cite journal | vauthors = Yamaguchi K, Nagai S, Ninomiya-Tsuji J, Nishita M, Tamai K, Irie K, Ueno N, Nishida E, Shibuya H, Matsumoto K | title = XIAP, a cellular member of the inhibitor of apoptosis protein family, links the receptors to TAB1-TAK1 in the BMP signaling pathway. | journal = EMBO J. | volume = 18 | issue = 1 | pages = 179–87 | year = 1999 | pmid = 9878061 | pmc = 1171113 | doi = 10.1093/emboj/18.1.179 }}
  • {{cite journal | vauthors = Ninomiya-Tsuji J, Kishimoto K, Hiyama A, Inoue J, Cao Z, Matsumoto K | title = The kinase TAK1 can activate the NIK-I kappaB as well as the MAP kinase cascade in the IL-1 signalling pathway. | journal = Nature | volume = 398 | issue = 6724 | pages = 252–6 | year = 1999 | pmid = 10094049 | doi = 10.1038/18465 }}
  • {{cite journal | vauthors = Dunham I, Shimizu N, Roe BA, Chissoe S, Hunt AR, Collins JE, Bruskiewich R, Beare DM, Clamp M, Smink LJ, Ainscough R, Almeida JP, Babbage A, Bagguley C, Bailey J, Barlow K, Bates KN, Beasley O, Bird CP, Blakey S, Bridgeman AM, Buck D, Burgess J, Burrill WD, O'Brien KP | title = The DNA sequence of human chromosome 22. | journal = Nature | volume = 402 | issue = 6761 | pages = 489–95 | year = 1999 | pmid = 10591208 | doi = 10.1038/990031 }}
  • {{cite journal | vauthors = Kishimoto K, Matsumoto K, Ninomiya-Tsuji J | title = TAK1 mitogen-activated protein kinase kinase kinase is activated by autophosphorylation within its activation loop. | journal = J. Biol. Chem. | volume = 275 | issue = 10 | pages = 7359–64 | year = 2000 | pmid = 10702308 | doi = 10.1074/jbc.275.10.7359 }}
  • {{cite journal | vauthors = Sakurai H, Miyoshi H, Mizukami J, Sugita T | title = Phosphorylation-dependent activation of TAK1 mitogen-activated protein kinase kinase kinase by TAB1. | journal = FEBS Lett. | volume = 474 | issue = 2–3 | pages = 141–5 | year = 2000 | pmid = 10838074 | doi = 10.1016/S0014-5793(00)01588-X }}
  • {{cite journal | vauthors = Ono K, Ohtomo T, Sato S, Sugamata Y, Suzuki M, Hisamoto N, Ninomiya-Tsuji J, Tsuchiya M, Matsumoto K | title = An evolutionarily conserved motif in the TAB1 C-terminal region is necessary for interaction with and activation of TAK1 MAPKKK. | journal = J. Biol. Chem. | volume = 276 | issue = 26 | pages = 24396–400 | year = 2001 | pmid = 11323434 | doi = 10.1074/jbc.M102631200 }}
  • {{cite journal | vauthors = Qian Y, Commane M, Ninomiya-Tsuji J, Matsumoto K, Li X | title = IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B. | journal = J. Biol. Chem. | volume = 276 | issue = 45 | pages = 41661–7 | year = 2001 | pmid = 11518704 | doi = 10.1074/jbc.M102262200 }}
  • {{cite journal | vauthors = Yanagisawa M, Nakashima K, Takeda K, Ochiai W, Takizawa T, Ueno M, Takizawa M, Shibuya H, Taga T | title = Inhibition of BMP2-induced, TAK1 kinase-mediated neurite outgrowth by Smad6 and Smad7. | journal = Genes Cells | volume = 6 | issue = 12 | pages = 1091–9 | year = 2002 | pmid = 11737269 | doi = 10.1046/j.1365-2443.2001.00483.x }}
  • {{cite journal | vauthors = Ge B, Gram H, Di Padova F, Huang B, New L, Ulevitch RJ, Luo Y, Han J | title = MAPKK-independent activation of p38alpha mediated by TAB1-dependent autophosphorylation of p38alpha. | journal = Science | volume = 295 | issue = 5558 | pages = 1291–4 | year = 2002 | pmid = 11847341 | doi = 10.1126/science.1067289 }}
  • {{cite journal | vauthors = Sakurai H, Nishi A, Sato N, Mizukami J, Miyoshi H, Sugita T | title = TAK1-TAB1 fusion protein: a novel constitutively active mitogen-activated protein kinase kinase kinase that stimulates AP-1 and NF-kappaB signaling pathways. | journal = Biochem. Biophys. Res. Commun. | volume = 297 | issue = 5 | pages = 1277–81 | year = 2002 | pmid = 12372426 | doi = 10.1016/S0006-291X(02)02379-3 }}
  • {{cite journal | vauthors = Ge B, Xiong X, Jing Q, Mosley JL, Filose A, Bian D, Huang S, Han J | title = TAB1beta (transforming growth factor-beta-activated protein kinase 1-binding protein 1beta ), a novel splicing variant of TAB1 that interacts with p38alpha but not TAK1. | journal = J. Biol. Chem. | volume = 278 | issue = 4 | pages = 2286–93 | year = 2003 | pmid = 12429732 | doi = 10.1074/jbc.M210918200 }}
  • {{cite journal | vauthors = Ishitani T, Kishida S, Hyodo-Miura J, Ueno N, Yasuda J, Waterman M, Shibuya H, Moon RT, Ninomiya-Tsuji J, Matsumoto K | title = The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling. | journal = Mol. Cell. Biol. | volume = 23 | issue = 1 | pages = 131–9 | year = 2003 | pmid = 12482967 | pmc = 140665 | doi = 10.1128/MCB.23.1.131-139.2003 }}
  • {{cite journal | vauthors = Suzawa M, Takada I, Yanagisawa J, Ohtake F, Ogawa S, Yamauchi T, Kadowaki T, Takeuchi Y, Shibuya H, Gotoh Y, Matsumoto K, Kato S | title = Cytokines suppress adipogenesis and PPAR-gamma function through the TAK1/TAB1/NIK cascade. | journal = Nat. Cell Biol. | volume = 5 | issue = 3 | pages = 224–30 | year = 2003 | pmid = 12598905 | doi = 10.1038/ncb942 }}
  • {{cite journal | vauthors = Tanno M, Bassi R, Gorog DA, Saurin AT, Jiang J, Heads RJ, Martin JL, Davis RJ, Flavell RA, Marber MS | title = Diverse mechanisms of myocardial p38 mitogen-activated protein kinase activation: evidence for MKK-independent activation by a TAB1-associated mechanism contributing to injury during myocardial ischemia. | journal = Circ. Res. | volume = 93 | issue = 3 | pages = 254–61 | year = 2003 | pmid = 12829618 | doi = 10.1161/01.RES.0000083490.43943.85 }}
  • {{cite journal | vauthors = Channavajhala PL, Wu L, Cuozzo JW, Hall JP, Liu W, Lin LL, Zhang Y | title = Identification of a novel human kinase supporter of Ras (hKSR-2) that functions as a negative regulator of Cot (Tpl2) signaling. | journal = J. Biol. Chem. | volume = 278 | issue = 47 | pages = 47089–97 | year = 2004 | pmid = 12975377 | doi = 10.1074/jbc.M306002200 }}
  • {{cite journal | vauthors = Cheung PC, Nebreda AR, Cohen P | title = TAB3, a new binding partner of the protein kinase TAK1. | journal = Biochem. J. | volume = 378 | issue = Pt 1 | pages = 27–34 | year = 2004 | pmid = 14670075 | pmc = 1223947 | doi = 10.1042/BJ20031794 }}
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