“MAP3K7IP2”的意思、由来-开放百科全书

The protein encoded by this gene is an activator of MAP3K7/TAK1, which is required for the IL-1 induced activation of nuclear factor kappaB and MAPK8/JNK. This protein forms a kinase complex with TRAF6, MAP3K7 and TAB1, thus serves as an adaptor linking MAP3K7 and TRAF6. This protein, TAB1, and MAP3K7 also participate in the signal transduction induced by TNFSF11/RANKL through the activation of the receptor activator of NF-kappB (TNFRSF11A/RANK), which may regulate the development and function of osteoclasts.^[3] Mutations in MAP3K7IP2 have been associated with human congenital heart defects.^[4]

References

1. ^{{cite journal | vauthors = Nagase T, Ishikawa K, Suyama M, Kikuno R, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro | journal = DNA Res | volume = 5 | issue = 5 | pages = 277–86 | date = Apr 1999 | pmid = 9872452 | pmc = | doi = 10.1093/dnares/5.5.277 }}
2. ^¹²³⁴{{cite journal | vauthors = Takaesu G, Kishida S, Hiyama A, Yamaguchi K, Shibuya H, Irie K, Ninomiya-Tsuji J, Matsumoto K | title = TAB2, a novel adaptor protein, mediates activation of TAK1 MAPKKK by linking TAK1 to TRAF6 in the IL-1 signal transduction pathway | journal = Mol Cell | volume = 5 | issue = 4 | pages = 649–58 | date = Jul 2000 | pmid = 10882101 | pmc = | doi = 10.1016/S1097-2765(00)80244-0 }}
3. ^¹{{cite web | title = Entrez Gene: MAP3K7IP2 mitogen-activated protein kinase kinase kinase 7 interacting protein 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23118| accessdate = }}
4. ^{{cite journal | vauthors = Thienpont B, Zhang L, Postma AV, Breckpot J, Tranchevent LC, Van Loo P, Møllgård K, Tommerup N, Bache I, Tümer Z, van Engelen K, Menten B, Mortier G, Waggoner D, Gewillig M, Moreau Y, Devriendt K, Larsen LA | title = Haploinsufficiency of TAB2 causes congenital heart defects in humans. | journal = Am J Hum Genet | volume = 86 | issue = 6 | pages = 839–49 | year = 2010 | pmid = 20493459 | pmc = 3032066 | doi = 10.1016/j.ajhg.2010.04.011 }}
5. ^{{cite journal | vauthors = Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G | title = A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway | journal = Nat. Cell Biol. | volume = 6 | issue = 2 | pages = 97–105 | date = Feb 2004 | pmid = 14743216 | doi = 10.1038/ncb1086 }}
6. ^¹{{cite journal | vauthors = Cheung PC, Nebreda AR, Cohen P | title = TAB3, a new binding partner of the protein kinase TAK1 | journal = Biochem. J. | volume = 378 | issue = Pt 1 | pages = 27–34 | date = Feb 2004 | pmid = 14670075 | pmc = 1223947 | doi = 10.1042/BJ20031794 }}
7. ^¹²{{cite journal | vauthors = Baek SH, Ohgi KA, Rose DW, Koo EH, Glass CK, Rosenfeld MG | title = Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein | journal = Cell | volume = 110 | issue = 1 | pages = 55–67 | date = Jul 2002 | pmid = 12150997 | doi = 10.1016/S0092-8674(02)00809-7}}
8. ^¹{{cite journal | vauthors = Ma Q, Zhou L, Shi H, Huo K | title = NUMBL interacts with TAB2 and inhibits TNFalpha and IL-1beta-induced NF-kappaB activation | journal = Cell. Signal. | volume = 20 | issue = 6 | pages = 1044–51 | date = Jun 2008 | pmid = 18299187 | doi = 10.1016/j.cellsig.2008.01.015 }}
9. ^{{cite journal | vauthors = Li S, Wang L, Dorf ME | title = PKC phosphorylation of TRAF2 mediates IKKalpha/beta recruitment and K63-linked polyubiquitination | journal = Mol. Cell | volume = 33 | issue = 1 | pages = 30–42 | date = Jan 2009 | pmid = 19150425 | pmc = 2643372 | doi = 10.1016/j.molcel.2008.11.023 }}
10. ^¹{{cite journal | vauthors = Ishitani T, Takaesu G, Ninomiya-Tsuji J, Shibuya H, Gaynor RB, Matsumoto K | title = Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling | journal = EMBO J. | volume = 22 | issue = 23 | pages = 6277–88 | date = Dec 2003 | pmid = 14633987 | pmc = 291846 | doi = 10.1093/emboj/cdg605 }}
11. ^¹{{cite journal | vauthors = Takaesu G, Ninomiya-Tsuji J, Kishida S, Li X, Stark GR, Matsumoto K | title = Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway | journal = Mol. Cell. Biol. | volume = 21 | issue = 7 | pages = 2475–84 | date = Apr 2001 | pmid = 11259596 | pmc = 86880 | doi = 10.1128/MCB.21.7.2475-2484.2001 }}
12. ^{{cite journal | vauthors = Walsh MC, Kim GK, Maurizio PL, Molnar EE, Choi Y | title = TRAF6 autoubiquitination-independent activation of the NFkappaB and MAPK pathways in response to IL-1 and RANKL | journal = PLoS ONE | volume = 3 | issue = 12 | pages = e4064 | pmid = 19112497 | pmc = 2603309 | doi = 10.1371/journal.pone.0004064 | editor1-last = Unutmaz | editor1-first = Derya }}
13. ^{{cite journal | vauthors = Windheim M, Stafford M, Peggie M, Cohen P | title = Interleukin-1 (IL-1) induces the Lys63-linked polyubiquitination of IL-1 receptor-associated kinase 1 to facilitate NEMO binding and the activation of IkappaBalpha kinase | journal = Mol. Cell. Biol. | volume = 28 | issue = 5 | pages = 1783–91 | date = Mar 2008 | pmid = 18180283 | pmc = 2258775 | doi = 10.1128/MCB.02380-06 }}

Further reading

{{cite journal | vauthors = Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T | title = Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones | journal = DNA Res. | volume = 9 | issue = 3 | pages = 99–106 | year = 2003 | pmid = 12168954 | doi = 10.1093/dnares/9.3.99 }}

{{cite journal | vauthors = Shibuya H, Yamaguchi K, Shirakabe K, Tonegawa A, Gotoh Y, Ueno N, Irie K, Nishida E, Matsumoto K | title = TAB1: an activator of the TAK1 MAPKKK in TGF-beta signal transduction | journal = Science | volume = 272 | issue = 5265 | pages = 1179–82 | year = 1996 | pmid = 8638164 | doi = 10.1126/science.272.5265.1179 }}

{{cite journal | vauthors = Takaesu G, Ninomiya-Tsuji J, Kishida S, Li X, Stark GR, Matsumoto K | title = Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway | journal = Mol. Cell. Biol. | volume = 21 | issue = 7 | pages = 2475–84 | year = 2001 | pmid = 11259596 | pmc = 86880 | doi = 10.1128/MCB.21.7.2475-2484.2001 }}

{{cite journal | vauthors = Qian Y, Commane M, Ninomiya-Tsuji J, Matsumoto K, Li X | title = IRAK-mediated translocation of TRAF6 and TAB2 in the interleukin-1-induced activation of NFkappa B | journal = J. Biol. Chem. | volume = 276 | issue = 45 | pages = 41661–7 | year = 2001 | pmid = 11518704 | doi = 10.1074/jbc.M102262200 }}

{{cite journal | vauthors = Mizukami J, Takaesu G, Akatsuka H, Sakurai H, Ninomiya-Tsuji J, Matsumoto K, Sakurai N | title = Receptor activator of NF-kappaB ligand (RANKL) activates TAK1 mitogen-activated protein kinase kinase kinase through a signaling complex containing RANK, TAB2, and TRAF6 | journal = Mol. Cell. Biol. | volume = 22 | issue = 4 | pages = 992–1000 | year = 2002 | pmid = 11809792 | pmc = 134634 | doi = 10.1128/MCB.22.4.992-1000.2002 }}

{{cite journal | vauthors = Sanna MG, da Silva Correia J, Luo Y, Chuang B, Paulson LM, Nguyen B, Deveraux QL, Ulevitch RJ | title = ILPIP, a novel anti-apoptotic protein that enhances XIAP-mediated activation of JNK1 and protection against apoptosis | journal = J. Biol. Chem. | volume = 277 | issue = 34 | pages = 30454–62 | year = 2002 | pmid = 12048196 | doi = 10.1074/jbc.M203312200 }}

{{cite journal | vauthors = Baek SH, Ohgi KA, Rose DW, Koo EH, Glass CK, Rosenfeld MG | title = Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein | journal = Cell | volume = 110 | issue = 1 | pages = 55–67 | year = 2002 | pmid = 12150997 | doi = 10.1016/S0092-8674(02)00809-7 }}

{{cite journal | vauthors = Jiang Z, Ninomiya-Tsuji J, Qian Y, Matsumoto K, Li X | title = Interleukin-1 (IL-1) receptor-associated kinase-dependent IL-1-induced signaling complexes phosphorylate TAK1 and TAB2 at the plasma membrane and activate TAK1 in the cytosol | journal = Mol. Cell. Biol. | volume = 22 | issue = 20 | pages = 7158–67 | year = 2002 | pmid = 12242293 | pmc = 139807 | doi = 10.1128/MCB.22.20.7158-7167.2002 }}

{{cite journal | vauthors = Jiang Z, Zamanian-Daryoush M, Nie H, Silva AM, Williams BR, Li X | title = Poly(I-C)-induced Toll-like receptor 3 (TLR3)-mediated activation of NFkappa B and MAP kinase is through an interleukin-1 receptor-associated kinase (IRAK)-independent pathway employing the signaling components TLR3-TRAF6-TAK1-TAB2-PKR | journal = J. Biol. Chem. | volume = 278 | issue = 19 | pages = 16713–9 | year = 2003 | pmid = 12609980 | doi = 10.1074/jbc.M300562200 }}

{{cite journal | vauthors = Matsuda A, Suzuki Y, Honda G, Muramatsu S, Matsuzaki O, Nagano Y, Doi T, Shimotohno K, Harada T, Nishida E, Hayashi H, Sugano S | title = Large-scale identification and characterization of human genes that activate NF-kappaB and MAPK signaling pathways | journal = Oncogene | volume = 22 | issue = 21 | pages = 3307–18 | year = 2003 | pmid = 12761501 | doi = 10.1038/sj.onc.1206406 }}

{{cite journal | vauthors = Ishitani T, Takaesu G, Ninomiya-Tsuji J, Shibuya H, Gaynor RB, Matsumoto K | title = Role of the TAB2-related protein TAB3 in IL-1 and TNF signaling | journal = EMBO J. | volume = 22 | issue = 23 | pages = 6277–88 | year = 2004 | pmid = 14633987 | pmc = 291846 | doi = 10.1093/emboj/cdg605 }}

{{cite journal | vauthors = Cheung PC, Nebreda AR, Cohen P | title = TAB3, a new binding partner of the protein kinase TAK1 | journal = Biochem. J. | volume = 378 | issue = Pt 1 | pages = 27–34 | year = 2004 | pmid = 14670075 | pmc = 1223947 | doi = 10.1042/BJ20031794 }}

{{cite journal | vauthors = Bouwmeester T, Bauch A, Ruffner H, Angrand PO, Bergamini G, Croughton K, Cruciat C, Eberhard D, Gagneur J, Ghidelli S, Hopf C, Huhse B, Mangano R, Michon AM, Schirle M, Schlegl J, Schwab M, Stein MA, Bauer A, Casari G, Drewes G, Gavin AC, Jackson DB, Joberty G, Neubauer G, Rick J, Kuster B, Superti-Furga G | title = A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway | journal = Nat. Cell Biol. | volume = 6 | issue = 2 | pages = 97–105 | year = 2004 | pmid = 14743216 | doi = 10.1038/ncb1086 }}

{{cite journal | vauthors = Owerbach D, Piña L, Gabbay KH | title = A 212-kb region on chromosome 6q25 containing the TAB2 gene is associated with susceptibility to type 1 diabetes | journal = Diabetes | volume = 53 | issue = 7 | pages = 1890–3 | year = 2004 | pmid = 15220215 | doi = 10.2337/diabetes.53.7.1890 }}

{{cite journal | vauthors = Kanayama A, Seth RB, Sun L, Ea CK, Hong M, Shaito A, Chiu YH, Deng L, Chen ZJ | title = TAB2 and TAB3 activate the NF-kappaB pathway through binding to polyubiquitin chains | journal = Mol. Cell | volume = 15 | issue = 4 | pages = 535–48 | year = 2004 | pmid = 15327770 | doi = 10.1016/j.molcel.2004.08.008 }}

Interactions

References

Further reading