“MAPKAP1”的意思、由来-开放百科全书

Target of rapamycin complex 2 subunit MAPKAP1 is a protein that in humans is encoded by the MAPKAP1 gene.^[1]^[2] As the name indicates, it is a subunit of mTOR complex 2.

References

1. ^{{cite journal |vauthors=Schroder W, Cloonan N, Bushell G, Sculley T | title = Alternative polyadenylation and splicing of mRNAs transcribed from the human Sin1 gene | journal = Gene | volume = 339 | issue = | pages = 17–23 |date=Sep 2004 | pmid = 15363842 | pmc = | doi = 10.1016/j.gene.2004.07.001 }}
2. ^¹{{cite web | title = Entrez Gene: MAPKAP1 mitogen-activated protein kinase associated protein 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79109| accessdate = }}

Further reading

{{cite journal | author=Colicelli J |title=Expression of three mammalian cDNAs that interfere with RAS function in Saccharomyces cerevisiae |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 7 |pages= 2913–7 |year= 1991 |pmid= 1849280 |doi=10.1073/pnas.88.7.2913 | pmc=51350 |name-list-format=vanc| author2=Nicolette C | author3=Birchmeier C | display-authors=3 | last4=Rodgers | first4=L | last5=Riggs | first5=M | last6=Wigler | first6=M }}

{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD }}

{{cite journal | author=Jin J |title=Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization |journal=Curr. Biol. |volume=14 |issue= 16 |pages= 1436–50 |year= 2004 |pmid= 15324660 |doi= 10.1016/j.cub.2004.07.051 |name-list-format=vanc| author2=Smith FD | author3=Stark C | display-authors=3 | last4=Wells | first4=Clark D. | last5=Fawcett | first5=James P. | last6=Kulkarni | first6=Sarang | last7=Metalnikov | first7=Pavel | last8=O'Donnell | first8=Paul | last9=Taylor | first9=Paul }}

{{cite journal | author=Gerhard DS |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }}

{{cite journal |vauthors=Schroder W, Bushell G, Sculley T |title=The human stress-activated protein kinase-interacting 1 gene encodes JNK-binding proteins |journal=Cell. Signal. |volume=17 |issue= 6 |pages= 761–7 |year= 2005 |pmid= 15722200 |doi= 10.1016/j.cellsig.2004.10.015 }}

{{cite journal | author=Benzinger A |title=Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer |journal=Mol. Cell. Proteomics |volume=4 |issue= 6 |pages= 785–95 |year= 2005 |pmid= 15778465 |doi= 10.1074/mcp.M500021-MCP200 |name-list-format=vanc| author2=Muster N | author3=Koch HB | display-authors=3 | last4=Yates Jr | first4=3rd | last5=Hermeking | first5=H }}

{{cite journal | author=Cheng J |title=Mip1, an MEKK2-Interacting Protein, Controls MEKK2 Dimerization and Activation |journal=Mol. Cell. Biol. |volume=25 |issue= 14 |pages= 5955–64 |year= 2005 |pmid= 15988011 |doi= 10.1128/MCB.25.14.5955-5964.2005 | pmc=1168836 |name-list-format=vanc| author2=Zhang D | author3=Kim K | display-authors=3 | last4=Zhao | first4=Y. | last5=Zhao | first5=Y. | last6=Su | first6=B. }}

{{cite journal | author=Venables JP |title=Up-regulation of the ubiquitous alternative splicing factor Tra2beta causes inclusion of a germ cell-specific exon |journal=Hum. Mol. Genet. |volume=14 |issue= 16 |pages= 2289–303 |year= 2005 |pmid= 16000324 |doi= 10.1093/hmg/ddi233 |name-list-format=vanc| author2=Bourgeois CF | author3=Dalgliesh C | display-authors=3 | last4=Kister | first4=L | last5=Stevenin | first5=J | last6=Elliott | first6=DJ }}

{{cite journal | author=Rual JF |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |name-list-format=vanc| author2=Venkatesan K | author3=Hao T | display-authors=3 | last4=Hirozane-Kishikawa | first4=Tomoko | last5=Dricot | first5=Amélie | last6=Li | first6=Ning | last7=Berriz | first7=Gabriel F. | last8=Gibbons | first8=Francis D. | last9=Dreze | first9=Matija }}

{{cite journal | author=Frias MA |title=mSin1 is necessary for Akt/PKB phosphorylation, and its isoforms define three distinct mTORC2s |journal=Curr. Biol. |volume=16 |issue= 18 |pages= 1865–70 |year= 2006 |pmid= 16919458 |doi= 10.1016/j.cub.2006.08.001 |name-list-format=vanc| author2=Thoreen CC | author3=Jaffe JD | display-authors=3 | last4=Schroder | first4=Wayne | last5=Sculley | first5=Tom | last6=Carr | first6=Steven A. | last7=Sabatini | first7=David M. }}

{{cite journal | author=Jacinto E |title=SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity |journal=Cell |volume=127 |issue= 1 |pages= 125–37 |year= 2006 |pmid= 16962653 |doi= 10.1016/j.cell.2006.08.033 |name-list-format=vanc| author2=Facchinetti V | author3=Liu D | display-authors=3 | last4=Soto | first4=Nelyn | last5=Wei | first5=Shiniu | last6=Jung | first6=Sung Yun | last7=Huang | first7=Qiaojia | last8=Qin | first8=Jun | last9=Su | first9=Bing }}

{{cite journal |vauthors=Yang Q, Inoki K, Ikenoue T, Guan KL |title=Identification of Sin1 as an essential TORC2 component required for complex formation and kinase activity |journal=Genes Dev. |volume=20 |issue= 20 |pages= 2820–32 |year= 2006 |pmid= 17043309 |doi= 10.1101/gad.1461206 | pmc=1619946 }}

{{cite journal | author=Makino C |title=Sin1 binds to both ATF-2 and p38 and enhances ATF-2-dependent transcription in an SAPK signaling pathway |journal=Genes Cells |volume=11 |issue= 11 |pages= 1239–51 |year= 2007 |pmid= 17054722 |doi= 10.1111/j.1365-2443.2006.01016.x |name-list-format=vanc| author2=Sano Y | author3=Shinagawa T | display-authors=3 | last4=Millar | first4=Jonathan B. A. | last5=Ishii | first5=Shunsuke }}

{{cite journal | author=Olsen JV |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 |name-list-format=vanc| author2=Blagoev B | author3=Gnad F | display-authors=3 | last4=Macek | first4=Boris | last5=Kumar | first5=Chanchal | last6=Mortensen | first6=Peter | last7=Mann | first7=Matthias }}

{{cite journal | author=Schroder WA |title=Human Sin1 contains Ras-binding and pleckstrin homology domains and suppresses Ras signalling |journal=Cell. Signal. |volume=19 |issue= 6 |pages= 1279–89 |year= 2007 |pmid= 17303383 |doi= 10.1016/j.cellsig.2007.01.013 |name-list-format=vanc| author2=Buck M | author3=Cloonan N | display-authors=3 | last4=Hancock | first4=John F. | last5=Suhrbier | first5=Andreas | last6=Sculley | first6=Tom | last7=Bushell | first7=Gillian }}