The Mark of Cain mainly refers to the Curse and mark of Cain from the Bible.

Mark of Cain may also refer to:ham son of Cain, and had Cain's mark .

• The Mark of Cain (band), an Australian band
• The Mark of Cain (1916 film), a 1916 American silent film starring Lon Chaney, Sr.
• The Mark of Cain (1917 film), a 1917 American silent mystery film directed by George Fitzmaurice
• The Mark of Cain (1947 film), a British film directed by Brian Desmond Hurt
• The Mark of Cain (2000 film), a 2000 documentary by Alix Lambert on Russian criminal tattoos
• The Mark of Cain (2007 film), a 2007 television film by Channel 4
• Mark of Cain (novel), a novel by Israeli author Ram Oren
• "Mark of Cain", a song by Therion from the album Crowning of Atlantis

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