Matheson House may refer to:

• Matheson House (Gainesville, Florida), a historic home on the National Register of Historic Places in the United States
• Matheson House (Perth), a National Historic Site of Canada in Perth, Ontario

• Oklahoma populism
• Oklahoma Presbyterian College
• Oklahoma primary electoral system
• Oklahoma Regents for Higher Education
• Oklahoma Renegades
• Oklahoma Republican primary, 2012
• Oklahoma rose
• Oklahoma Rough Riders
• Oklahoma Route 66 Association
• Oklahoma Route 66 Museum
• Oklahoma Salamander
• Oklahoma's At-large congressional district
• Oklahoma's At-large congressional seat
• Oklahoma Seminole
• Oklahoma Senate Majority Leader
• Oklahoma Smiles
• Oklahoma Smiles Dental Centers
• Oklahoma Sooners football, 1895–1899
• Oklahoma Sooners football, 1900–1909
• Oklahoma Sooners football, 1910–1919
• Oklahoma Sooners football, 1920–1929
• Oklahoma Sooners football, 1930–1939
• Oklahoma Sooners football, 1940–1949
• Oklahoma Sooners football statistical leaders
• Oklahoma Sooners men's cross country