“MCF2”的意思、由来-开放百科全书

MCF2 is a member of a large family of GDP-GTP exchange factors that modulate the activity of small GTPases of the Rho family. Five-prime recombinations result in the loss of N-terminal codons, producing MCF2 variants with oncogenic potential.[supplied by OMIM]^[3]

References

1. ^{{cite journal |vauthors=Noguchi T, Galland F, Batoz M, Mattei MG, Birnbaum D | title = Activation of a mcf.2 oncogene by deletion of amino-terminal coding sequences | journal = Oncogene | volume = 3 | issue = 6 | pages = 709–15 |date=Apr 1994 | pmid = 2577874 | pmc = | doi = }}
2. ^{{cite journal |vauthors=Galland F, Stefanova M, Lafage M, Birnbaum D | title = Localization of the 5' end of the MCF2 oncogene to human chromosome 15q15----q23 | journal = Cytogenet Cell Genet | volume = 60 | issue = 2 | pages = 114–6 |date=Jul 1992 | pmid = 1611909 | pmc = | doi =10.1159/000133316 }}
3. ^¹{{cite web | title = Entrez Gene: MCF2 MCF.2 cell line derived transforming sequence| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4168| accessdate = }}

Further reading

{{cite journal | author=Ron D |title=A region of proto-dbl essential for its transforming activity shows sequence similarity to a yeast cell cycle gene, CDC24, and the human breakpoint cluster gene, bcr |journal=New Biol. |volume=3 |issue= 4 |pages= 372–9 |year= 1991 |pmid= 2065022 |doi= |name-list-format=vanc| author2=Zannini M | author3=Lewis M | display-authors=3 | last4=Wickner | first4=RB | last5=Hunt | first5=LT | last6=Graziani | first6=G | last7=Tronick | first7=SR | last8=Aaronson | first8=SA | last9=Eva | first9=A }}

{{cite journal |vauthors=Tronick SR, McBride OW, Popescu NC, Eva A |title=Chromosomal localization of DBL oncogene sequences |journal=Genomics |volume=5 |issue= 3 |pages= 546–53 |year= 1990 |pmid= 2613238 |doi=10.1016/0888-7543(89)90022-0 |url=https://zenodo.org/record/1258565 |format=Submitted manuscript }}

{{cite journal | author=Ron D, Tronick SR, Aaronson SA, Eva A |title=Molecular cloning and characterization of the human dbl proto-oncogene: evidence that its overexpression is sufficient to transform NIH/3T3 cells |journal=EMBO J. |volume=7 |issue= 8 |pages= 2465–73 |year= 1989 |pmid= 3056717 |doi= | pmc=457116 }}

{{cite journal | author=Eva A |title=The predicted DBL oncogene product defines a distinct class of transforming proteins |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=85 |issue= 7 |pages= 2061–5 |year= 1988 |pmid= 3281159 |doi=10.1073/pnas.85.7.2061 | pmc=279928 |name-list-format=vanc| author2=Vecchio G | author3=Rao CD | display-authors=3 | last4=Tronick | first4=SR | last5=Aaronson | first5=SA }}

{{cite journal |vauthors=Srivastava SK, Wheelock RH, Aaronson SA, Eva A |title=Identification of the protein encoded by the human diffuse B-cell lymphoma (dbl) oncogene |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=83 |issue= 23 |pages= 8868–72 |year= 1987 |pmid= 3491366 |doi=10.1073/pnas.83.23.8868 | pmc=387034 }}

{{cite journal | author=Hart MJ |title=Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product |journal=J. Biol. Chem. |volume=269 |issue= 1 |pages= 62–5 |year= 1994 |pmid= 8276860 |doi= |name-list-format=vanc| author2=Eva A | author3=Zangrilli D | display-authors=3 | last4=Aaronson | first4=SA | last5=Evans | first5=T | last6=Cerione | first6=RA | last7=Zheng | first7=Y }}

{{cite journal |vauthors=Nishida K, Kaziro Y, Satoh T |title=Association of the proto-oncogene product dbl with G protein betagamma subunits |journal=FEBS Lett. |volume=459 |issue= 2 |pages= 186–90 |year= 1999 |pmid= 10518015 |doi=10.1016/S0014-5793(99)01244-2 }}

{{cite journal |vauthors=Kato J, Kaziro Y, Satoh T |title=Activation of the guanine nucleotide exchange factor Dbl following ACK1-dependent tyrosine phosphorylation |journal=Biochem. Biophys. Res. Commun. |volume=268 |issue= 1 |pages= 141–7 |year= 2000 |pmid= 10652228 |doi= 10.1006/bbrc.2000.2106 }}

{{cite journal |vauthors=Zhu K, Debreceni B, Li R, Zheng Y |title=Identification of Rho GTPase-dependent sites in the Dbl homology domain of oncogenic Dbl that are required for transformation |journal=J. Biol. Chem. |volume=275 |issue= 34 |pages= 25993–6001 |year= 2000 |pmid= 10854437 |doi= 10.1074/jbc.M003780200 }}

{{cite journal | author=Palmieri G |title=Human dbl proto-oncogene in 85 kb of xq26, and determination of the transcription initiation site |journal=Gene |volume=253 |issue= 1 |pages= 107–15 |year= 2000 |pmid= 10925207 |doi=10.1016/S0378-1119(00)00212-2 |name-list-format=vanc| author2=de Franciscis V | author3=Casamassimi A | display-authors=3 | last4=Romano | first4=G | last5=Torino | first5=A | last6=Pingitore | first6=P | last7=Califano | first7=D | last8=Santelli | first8=G | last9=Eva | first9=A }}

{{cite journal |vauthors=Jin S, Exton JH |title=Activation of RhoA by association of Galpha(13) with Dbl |journal=Biochem. Biophys. Res. Commun. |volume=277 |issue= 3 |pages= 718–21 |year= 2000 |pmid= 11062019 |doi= 10.1006/bbrc.2000.3744 }}

{{cite journal |vauthors=Zhu K, Debreceni B, Bi F, Zheng Y |title=Oligomerization of DH domain is essential for Dbl-induced transformation |journal=Mol. Cell. Biol. |volume=21 |issue= 2 |pages= 425–37 |year= 2001 |pmid= 11134331 |doi= 10.1128/MCB.21.2.425-437.2001 | pmc=86589 }}

{{cite journal | author=Vanni C |title=Regulation of proto-Dbl by intracellular membrane targeting and protein stability |journal=J. Biol. Chem. |volume=277 |issue= 22 |pages= 19745–53 |year= 2002 |pmid= 11907027 |doi= 10.1074/jbc.M111025200 |name-list-format=vanc| author2=Mancini P | author3=Gao Y | display-authors=3 | last4=Ottaviano | first4=C | last5=Guo | first5=F | last6=Salani | first6=B | last7=Torrisi | first7=MR | last8=Zheng | first8=Y | last9=Eva | first9=A }}

{{cite journal | author=Wennerberg K |title=RhoG signals in parallel with Rac1 and Cdc42 |journal=J. Biol. Chem. |volume=277 |issue= 49 |pages= 47810–7 |year= 2003 |pmid= 12376551 |doi= 10.1074/jbc.M203816200 |name-list-format=vanc| author2=Ellerbroek SM | author3=Liu RY | display-authors=3 | last4=Karnoub | first4=AE | last5=Burridge | first5=K | last6=Der | first6=CJ }}

{{cite journal | author=Komai K |title=Alternative splicing variants of the human DBL (MCF-2) proto-oncogene |journal=Biochem. Biophys. Res. Commun. |volume=299 |issue= 3 |pages= 455–8 |year= 2003 |pmid= 12445822 |doi=10.1016/S0006-291X(02)02645-1 |name-list-format=vanc| author2=Okayama R | author3=Kitagawa M | display-authors=3 | last4=Yagi | first4=H | last5=Chihara | first5=K | last6=Shiozawa | first6=S }}

{{cite journal |vauthors=Komai K, Mukae-Sakairi N, Kitagawa M, Shiozawa S |title=Characterization of novel splicing variants of the mouse MCF-2 (DBL) proto-oncogene |journal=Biochem. Biophys. Res. Commun. |volume=309 |issue= 4 |pages= 906–9 |year= 2003 |pmid= 13679059 |doi=10.1016/j.bbrc.2003.08.088 }}

{{cite journal | author=Ross MT |title=The DNA sequence of the human X chromosome |journal=Nature |volume=434 |issue= 7031 |pages= 325–37 |year= 2005 |pmid= 15772651 |doi= 10.1038/nature03440 | pmc=2665286 |name-list-format=vanc| author2=Grafham DV | author3=Coffey AJ | display-authors=3 | last4=Scherer | first4=Steven | last5=McLay | first5=Kirsten | last6=Muzny | first6=Donna | last7=Platzer | first7=Matthias | last8=Howell | first8=Gareth R. | last9=Burrows | first9=Christine }}

{{cite journal | author=Kimura K |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 |name-list-format=vanc| author2=Wakamatsu A | author3=Suzuki Y | display-authors=3 | last4=Ota | first4=T | last5=Nishikawa | first5=T | last6=Yamashita | first6=R | last7=Yamamoto | first7=J | last8=Sekine | first8=M | last9=Tsuritani | first9=K }}