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词条 MCF-7
释义

  1. Characteristics of MCF-7 cells

  2. References

  3. External links

MCF-7 is a breast cancer cell line isolated in 1970 from a 69-year-old Caucasian woman.[1] MCF-7 is the acronym of Michigan Cancer Foundation-7, referring to the institute in Detroit where the cell line was established in 1973 by Herbert Soule and co-workers.[2] The Michigan Cancer Foundation is now known as the Barbara Ann Karmanos Cancer Institute.[3]

Prior to MCF-7, it was not possible for cancer researchers to obtain a mammary cell line that was capable of living longer than a few months.[4]

The patient, Frances Mallon died in 1970. Her cells were the source of much of current knowledge about breast cancer.[2][5] At the time of sampling, she was a nun in the convent of Immaculate Heart of Mary in Monroe, Michigan under the name of Sister Catherine Frances.

MCF-7 and two other breast cancer cell lines, named T-47D and MDA-MB-231, account for more than two-thirds of all abstracts reporting studies on mentioned breast cancer cell lines, as concluded from a Medline-based survey.[6]

Characteristics of MCF-7 cells

MCF-7 cells have the following characteristics:[2][5][6][7][8][9]

  • Primary tumor (invasive breast ductal carcinoma)
  • Originate from pleural effusion
  • Estrogen receptors present[10]
  • Proliferative response to estrogens
  • Presence of progesterone receptors
  • Cannot have ERBB2 gene amplification (with Her2/neu protein overexpression)
  • Tumorigenic in mice but only with estrogen supplementation if engrafted into the subcutaneous fat or mammary fat pad
  • Tumorigenic in mice without estrogen supplementation if engrafted intraductally[11]
  • Luminal epithelial phenotype

This cell line retained several characteristics of differentiated mammary epithelium, including the ability to process estradiol via cytoplasmic estrogen receptors and the capability of forming domes.{{citation needed|date=December 2017}}

Tumor necrosis factor alpha (TNF alpha) inhibits the growth of MCF-7 breast cancer cells. Treatment with anti-estrogens can modulate the secretion of insulin-like growth factor binding proteins. Omega-3 and 6 fatty acids such as EPA, DHA and AA has been reported to inhibit MCF-7 cell line growth and proliferation.[12]

PIK3CA helical mutations were identified in MCF-7,[13] but with low AKT activation.[14]

References

1. ^{{cite journal|journal=Journal of the National Cancer Institute|volume=107|issue=7|pages=djv073|date=1 July 2015|doi=10.1093/jnci/djv073|pmid = 25828948|first1=Adrian V. |last1=Lee|display-authors=etal|title=MCF-7 Cells—Changing the Course of Breast Cancer Research and Care for 45 Years}}
2. ^1 2 {{cite journal | first=HD | last= Soule |author2=Vazquez J |author3=Long A |author4=Albert S |author5=Brennan M. | title= A human cell line from a pleural effusion derived from a breast carcinoma | journal= Journal of the National Cancer Institute | year=1973 | volume=51 | issue=5 |pages=1409–1416 | pmid=4357757| doi= 10.1093/jnci/51.5.1409 }}
3. ^http://www.cancer.gov {{cite web |url=http://www.cancer.gov/ncicancerbulletin/NCI_Cancer_Bulletin_042908/page9 |title=Archived copy |accessdate=2010-04-28 |deadurl=yes |archiveurl=https://web.archive.org/web/20100527125836/http://www.cancer.gov/ncicancerbulletin/NCI_Cancer_Bulletin_042908/page9 |archivedate=2010-05-27 |df= }} Retrieved on 2010-04-28
4. ^Glodek, Cass, Ph.D., "A History of the Michigan Cancer Foundation, the Beginnings & Growth of Detroit's Anticancer Movement," 1990, page 68, Michigan Cancer Foundation, Detroit.
5. ^1 {{cite journal | first=AS | last= Levenson |author2=Jordan VC. | title= MCF-7: the first hormone-responsive breast cancer cell line | journal= Cancer Research | year=1997 | volume=57 | issue=15 |pages=3071–3078 | pmid=9242427}}
6. ^1 {{cite journal | doi=10.1023/B:BREA.0000014042.54925.cc | first=M | last= Lacroix |author2=Leclercq G. | title= Relevance of breast cancer cell lines as models for breast tumours: an update | journal= Breast Research and Treatment | year=2004 | volume=83 | issue=3 |pages=249–289 | pmid=14758095}}
7. ^{{cite journal | first=DT | last= Ross |author2=Perou CM. | title= A comparison of gene expression signatures from breast tumors and breast tissue derived cell lines | journal=Disease Markers | year=2001 | volume=17 | issue=2 |pages=99–109 | pmid=11673656 | pmc= 3850857 | doi=10.1155/2001/850531}}
8. ^{{cite journal | doi=10.1038/sj.onc.1209254 | first=E | last= Charafe-Jauffret |author2=Ginestier C |author3=Monville F |author4=Finetti P |author5=Adelaide J |author6=Cervera N |author7=Fekairi S |author8=Xerri L |author9=Jacquemier J |author10=Birnbaum D |author11=Bertucci F. | title= Gene expression profiling of breast cell lines identifies potential new basal markers | journal= Oncogene | year=2006 | volume=25 | issue=15 |pages=2273–2284 | pmid=16288205}}
9. ^{{cite journal | doi=10.1677/erc.1.01172 | first=M | last= Lacroix |author2=Toillon RA |author3=Leclercq G. | title= p53 and breast cancer, an update | journal= Endocrine-Related Cancer | publisher= Bioscientifica| year=2006 | volume=13 | issue=2 |pages=293–325 | pmid=16728565}}
10. ^{{cite web|title=MCF-7 Cells: human breast adenocarcinoma cell line|last1=Fanelli|first1=Alex|date=2016|access-date=3 December 2017|url=http://www.mcf7.com/}}
11. ^{{Cite journal|last=Sflomos|first=George|last2=Dormoy|first2=Valerian|last3=Metsalu|first3=Tauno|last4=Jeitziner|first4=Rachel|last5=Battista|first5=Laura|last6=Scabia|first6=Valentina|last7=Raffoul|first7=Wassim|last8=Delaloye|first8=Jean-Francois|last9=Treboux|first9=Assya|title=A Preclinical Model for ERα-Positive Breast Cancer Points to the Epithelial Microenvironment as Determinant of Luminal Phenotype and Hormone Response|journal=Cancer Cell|volume=29|issue=3|pages=407–422|doi=10.1016/j.ccell.2016.02.002|pmid=26947176|year=2016}}
12. ^{{cite journal|last1=Mansara|first1=Prakash P.|last2=Deshpande|first2=Rashmi A.|last3=Vaidya|first3=Milind M.|last4=Kaul-Ghanekar|first4=Ruchika|title=Differential Ratios of Omega Fatty Acids (AA/EPA+DHA) Modulate Growth, Lipid Peroxidation and Expression of Tumor Regulatory MARBPs in Breast Cancer Cell Lines MCF7 and MDA-MB-231|journal=PLOS ONE|date=1 September 2015|volume=10|issue=9|pages=e0136542|doi=10.1371/journal.pone.0136542|pmid=26325577|pmc=4556657|issn=1932-6203}}
13. ^{{Cite web|url=http://cancer.sanger.ac.uk/cosmic/sample/overview?id=1289391|title=COSMIC: Sample overview for 1289391|last=Cosmic|website=cancer.sanger.ac.uk|access-date=2017-05-10}}
14. ^{{Cite journal|last=Vasudevan|first=Krishna M.|last2=Barbie|first2=David A.|last3=Davies|first3=Michael A.|last4=Rabinovsky|first4=Rosalia|last5=McNear|first5=Chontelle J.|last6=Kim|first6=Jessica J.|last7=Hennessy|first7=Bryan T.|last8=Tseng|first8=Hsiuyi|last9=Pochanard|first9=Panisa|date=2009-07-07|title=AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer|journal=Cancer Cell|volume=16|issue=1|pages=21–32|doi=10.1016/j.ccr.2009.04.012|issn=1878-3686|pmc=2752826|pmid=19573809}}

External links

{{Commonscat|MCF-7 cells}}
  • The University of Texas MD Anderson Breast Cancer Cell Line Data Base
  • [https://web.expasy.org/cellosaurus/CVCL_0031 Cellosaurus entry for MCF-7]
{{DEFAULTSORT:Mcf-7}}

2 : Human cell lines|Breast cancer
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