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词条 MCM3AP
释义

  1. Function

  2. Interactions

  3. References

  4. Further reading

{{Infobox_gene}}80 kDa MCM3-associated protein is a protein that in humans is encoded by the MCM3AP gene.[1][2]

Function

The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is an MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization.[2]

Interactions

MCM3AP has been shown to interact with:

  • MCM3[1][3][4] and
  • TRIB3.[5]

References

1. ^1 {{cite journal | vauthors = Takei Y, Tsujimoto G | title = Identification of a novel MCM3-associated protein that facilitates MCM3 nuclear localization | journal = J. Biol. Chem. | volume = 273 | issue = 35 | pages = 22177–80 | date = September 1998 | pmid = 9712829 | pmc = | doi = 10.1074/jbc.273.35.22177 }}
2. ^1 {{cite web | title = Entrez Gene: MCM3AP MCM3 minichromosome maintenance deficient 3 (S. cerevisiae) associated protein| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8888| accessdate = }}
3. ^{{cite journal | vauthors = Takei Y, Assenberg M, Tsujimoto G, Laskey R | title = The MCM3 acetylase MCM3AP inhibits initiation, but not elongation, of DNA replication via interaction with MCM3 | journal = J. Biol. Chem. | volume = 277 | issue = 45 | pages = 43121–5 | date = November 2002 | pmid = 12226073 | doi = 10.1074/jbc.C200442200 }}
4. ^{{cite journal | vauthors = Kuwahara K, Yoshida M, Kondo E, Sakata A, Watanabe Y, Abe E, Kouno Y, Tomiyasu S, Fujimura S, Tokuhisa T, Kimura H, Ezaki T, Sakaguchi N | title = A novel nuclear phosphoprotein, GANP, is up-regulated in centrocytes of the germinal center and associated with MCM3, a protein essential for DNA replication | journal = Blood | volume = 95 | issue = 7 | pages = 2321–8 | date = April 2000 | pmid = 10733502 | doi = }}
5. ^{{cite journal | vauthors = Zhou Y, Li L, Liu Q, Xing G, Kuai X, Sun J, Yin X, Wang J, Zhang L, He F | title = E3 ubiquitin ligase SIAH1 mediates ubiquitination and degradation of TRB3 | journal = Cell. Signal. | volume = 20 | issue = 5 | pages = 942–8 | date = May 2008 | pmid = 18276110 | doi = 10.1016/j.cellsig.2008.01.010 }}

Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Res. | volume = 5 | issue = 1 | pages = 31–9 | year = 1998 | pmid = 9628581 | doi = 10.1093/dnares/5.1.31 }}
  • {{cite journal | vauthors = Kuwahara K, Yoshida M, Kondo E, Sakata A, Watanabe Y, Abe E, Kouno Y, Tomiyasu S, Fujimura S, Tokuhisa T, Kimura H, Ezaki T, Sakaguchi N | title = A novel nuclear phosphoprotein, GANP, is up-regulated in centrocytes of the germinal center and associated with MCM3, a protein essential for DNA replication | journal = Blood | volume = 95 | issue = 7 | pages = 2321–8 | year = 2000 | pmid = 10733502 | doi = }}
  • {{cite journal | vauthors = Abe E, Kuwahara K, Yoshida M, Suzuki M, Terasaki H, Matsuo Y, Takahashi EI, Sakaguchi N | title = Structure, expression, and chromosomal localization of the human gene encoding a germinal center-associated nuclear protein (GANP) that associates with MCM3 involved in the initiation of DNA replication | journal = Gene | volume = 255 | issue = 2 | pages = 219–27 | year = 2000 | pmid = 11024281 | doi = 10.1016/S0378-1119(00)00336-X }}
  • {{cite journal | vauthors = Takei Y, Swietlik M, Tanoue A, Tsujimoto G, Kouzarides T, Laskey R | title = MCM3AP, a novel acetyltransferase that acetylates replication protein MCM3 | journal = EMBO Rep. | volume = 2 | issue = 2 | pages = 119–23 | year = 2001 | pmid = 11258703 | pmc = 1083822 | doi = 10.1093/embo-reports/kve026 }}
  • {{cite journal | vauthors = Kuwahara K, Tomiyasu S, Fujimura S, Nomura K, Xing Y, Nishiyama N, Ogawa M, Imajoh-Ohmi S, Izuta S, Sakaguchi N | title = Germinal center-associated nuclear protein (GANP) has a phosphorylation-dependent DNA-primase activity that is up-regulated in germinal center regions | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 18 | pages = 10279–83 | year = 2001 | pmid = 11526238 | pmc = 56952 | doi = 10.1073/pnas.181335698 }}
  • {{cite journal | vauthors = EL-Gazzar MA, Maeda K, Nomiyama H, Nakao M, Kuwahara K, Sakaguchi N | title = PU.1 is involved in the regulation of B lineage-associated and developmental stage-dependent expression of the germinal center-associated DNA primase GANP | journal = J. Biol. Chem. | volume = 276 | issue = 51 | pages = 48000–8 | year = 2001 | pmid = 11641399 | doi = 10.1074/jbc.M106696200 }}
  • {{cite journal | vauthors = Kono Y, Maeda K, Kuwahara K, Yamamoto H, Miyamoto E, Yonezawa K, Takagi K, Sakaguchi N | title = MCM3-binding GANP DNA-primase is associated with a novel phosphatase component G5PR | journal = Genes Cells | volume = 7 | issue = 8 | pages = 821–34 | year = 2002 | pmid = 12167160 | doi = 10.1046/j.1365-2443.2002.00562.x }}
  • {{cite journal | vauthors = Takei Y, Assenberg M, Tsujimoto G, Laskey R | title = The MCM3 acetylase MCM3AP inhibits initiation, but not elongation, of DNA replication via interaction with MCM3 | journal = J. Biol. Chem. | volume = 277 | issue = 45 | pages = 43121–5 | year = 2002 | pmid = 12226073 | doi = 10.1074/jbc.C200442200 }}
  • {{cite journal | vauthors = Nakayama M, Kikuno R, Ohara O | title = Protein-protein interactions between large proteins: two-hybrid screening using a functionally classified library composed of long cDNAs | journal = Genome Res. | volume = 12 | issue = 11 | pages = 1773–84 | year = 2002 | pmid = 12421765 | pmc = 187542 | doi = 10.1101/gr.406902 }}
  • {{cite journal | vauthors = Sakaguchi N, Fujimura S, Kuwahara K | title = Involvement of GANP in B cell activation in T cell-dependent antigen response | journal = Dev. Immunol. | volume = 9 | issue = 3 | pages = 169–72 | year = 2002 | pmid = 12885157 | pmc = 2276099 | doi = 10.1080/1044667031000137647 }}
  • {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional proteomics mapping of a human signaling pathway | journal = Genome Res. | volume = 14 | issue = 7 | pages = 1324–32 | year = 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}
  • {{cite journal | vauthors = Hu YH, Warnatz HJ, Vanhecke D, Wagner F, Fiebitz A, Thamm S, Kahlem P, Lehrach H, Yaspo ML, Janitz M | title = Cell array-based intracellular localization screening reveals novel functional features of human chromosome 21 proteins | journal = BMC Genomics | volume = 7 | pages = 155 | year = 2006 | pmid = 16780588 | pmc = 1526728 | doi = 10.1186/1471-2164-7-155 }}
{{refend}}{{gene-21-stub}}
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