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词条 MDM4
释义

  1. Function

  2. Interactions

  3. References

  4. Further reading

{{Infobox_gene}}Protein Mdm4 is a protein that in humans is encoded by the MDM4 gene.[1][2]

Function

The human MDM4 gene, which plays a role in apoptosis, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins contain, is located in the C-terminal region of the protein. The mRNA is expressed at a high level in thymus and at lower levels in all other tissues tested. MDM4 protein produced by in vitro translation interacts with p53 via a binding domain located in the N-terminal region of the MDM4 protein. MDM4 shows significant structural similarity to p53-binding protein MDM2[3]

Interactions

MDM4 has been shown to interact with E2F1,[4] Mdm2[5][6][7][8] and P53.[1][7]

References

1. ^1 {{cite journal | vauthors = Shvarts A, Bazuine M, Dekker P, Ramos YF, Steegenga WT, Merckx G, van Ham RC, van der Houven van Oordt W, van der Eb AJ, Jochemsen AG | title = Isolation and identification of the human homolog of a new p53-binding protein, Mdmx | journal = Genomics | volume = 43 | issue = 1 | pages = 34–42 | date = Sep 1997 | pmid = 9226370 | pmc = | doi = 10.1006/geno.1997.4775 }}
2. ^{{cite web | title = Entrez Gene: MDM4 Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4194| accessdate = }}
3. ^{{cite web | title = Entrez Gene: MDM4 Mdm4, transformed 3T3 cell double minute 4, p53 binding protein (mouse)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4194| accessdate = }}
4. ^{{cite journal | vauthors = Strachan GD, Jordan-Sciutto KL, Rallapalli R, Tuan RS, Hall DJ | title = The E2F-1 transcription factor is negatively regulated by its interaction with the MDMX protein | journal = J. Cell. Biochem. | volume = 88 | issue = 3 | pages = 557–68 | date = Feb 2003 | pmid = 12532331 | doi = 10.1002/jcb.10318 }}
5. ^{{cite journal | vauthors = Kadakia M, Brown TL, McGorry MM, Berberich SJ | title = MdmX inhibits Smad transactivation | journal = Oncogene | volume = 21 | issue = 57 | pages = 8776–85 | date = Dec 2002 | pmid = 12483531 | doi = 10.1038/sj.onc.1205993 }}
6. ^{{cite journal | vauthors = Tanimura S, Ohtsuka S, Mitsui K, Shirouzu K, Yoshimura A, Ohtsubo M | title = MDM2 interacts with MDMX through their RING finger domains | journal = FEBS Lett. | volume = 447 | issue = 1 | pages = 5–9 | date = Mar 1999 | pmid = 10218570 | doi = 10.1016/S0014-5793(99)00254-9 }}
7. ^1 {{cite journal | vauthors = Badciong JC, Haas AL | title = MdmX is a RING finger ubiquitin ligase capable of synergistically enhancing Mdm2 ubiquitination | journal = J. Biol. Chem. | volume = 277 | issue = 51 | pages = 49668–75 | date = Dec 2002 | pmid = 12393902 | doi = 10.1074/jbc.M208593200 }}
8. ^{{cite journal | vauthors = Linke K, Mace PD, Smith CA, Vaux DL, Silke J, Day CL | title = Structure of the MDM2/MDMX RING domain heterodimer reveals dimerization is required for their ubiquitylation in trans | journal = Cell Death Differ. | volume = 15 | issue = 5 | pages = 841–8 | date = May 2008 | pmid = 18219319 | doi = 10.1038/sj.cdd.4402309 }}
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Further reading

{{refbegin | 2}}
  • {{cite journal | vauthors = Meulmeester E, Pereg Y, Shiloh Y, Jochemsen AG | title = ATM-mediated phosphorylations inhibit Mdmx/Mdm2 stabilization by HAUSP in favor of p53 activation. | journal = Cell Cycle | volume = 4 | issue = 9 | pages = 1166–70 | year = 2006 | pmid = 16082221 | doi = 10.4161/cc.4.9.1981 }}
  • {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. | journal = Gene | volume = 138 | issue = 1–2 | pages = 171–4 | year = 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
  • {{cite journal | vauthors = Shvarts A, Steegenga WT, Riteco N, van Laar T, Dekker P, Bazuine M, van Ham RC, van der Houven van Oordt W, Hateboer G, van der Eb AJ, Jochemsen AG | title = MDMX: a novel p53-binding protein with some functional properties of MDM2 | journal = EMBO J. | volume = 15 | issue = 19 | pages = 5349–57 | year = 1996 | pmid = 8895579 | pmc = 452278 | doi = }}
  • {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1–2 | pages = 149–56 | year = 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
  • {{cite journal | vauthors = Tanimura S, Ohtsuka S, Mitsui K, Shirouzu K, Yoshimura A, Ohtsubo M | title = MDM2 interacts with MDMX through their RING finger domains | journal = FEBS Lett. | volume = 447 | issue = 1 | pages = 5–9 | year = 1999 | pmid = 10218570 | doi = 10.1016/S0014-5793(99)00254-9 }}
  • {{cite journal | vauthors = Ongkeko WM, Wang XQ, Siu WY, Lau AW, Yamashita K, Harris AL, Cox LS, Poon RY | title = MDM2 and MDMX bind and stabilize the p53-related protein p73 | journal = Curr. Biol. | volume = 9 | issue = 15 | pages = 829–32 | year = 1999 | pmid = 10469568 | doi = 10.1016/S0960-9822(99)80367-4 }}
  • {{cite journal | vauthors = Sharp DA, Kratowicz SA, Sank MJ, George DL | title = Stabilization of the MDM2 oncoprotein by interaction with the structurally related MDMX protein | journal = J. Biol. Chem. | volume = 274 | issue = 53 | pages = 38189–96 | year = 2000 | pmid = 10608892 | doi = 10.1074/jbc.274.53.38189 }}
  • {{cite journal | vauthors = Jackson MW, Lindstrom MS, Berberich SJ | title = MdmX binding to ARF affects Mdm2 protein stability and p53 transactivation | journal = J. Biol. Chem. | volume = 276 | issue = 27 | pages = 25336–41 | year = 2001 | pmid = 11297540 | doi = 10.1074/jbc.M010685200 }}
  • {{cite journal | vauthors = Parant J, Chavez-Reyes A, Little NA, Yan W, Reinke V, Jochemsen AG, Lozano G | title = Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53 | journal = Nat. Genet. | volume = 29 | issue = 1 | pages = 92–5 | year = 2001 | pmid = 11528400 | doi = 10.1038/ng714 }}
  • {{cite journal | vauthors = Gentiletti F, Mancini F, D'Angelo M, Sacchi A, Pontecorvi A, Jochemsen AG, Moretti F | title = MDMX stability is regulated by p53-induced caspase cleavage in NIH3T3 mouse fibroblasts | journal = Oncogene | volume = 21 | issue = 6 | pages = 867–77 | year = 2002 | pmid = 11840332 | doi = 10.1038/sj.onc.1205137 }}
  • {{cite journal | vauthors = Harris RA, Yang A, Stein RC, Lucy K, Brusten L, Herath A, Parekh R, Waterfield MD, O'Hare MJ, Neville MA, Page MJ, Zvelebil MJ | title = Cluster analysis of an extensive human breast cancer cell line protein expression map database | journal = Proteomics | volume = 2 | issue = 2 | pages = 212–23 | year = 2002 | pmid = 11840567 | doi = 10.1002/1615-9861(200202)2:2<212::AID-PROT212>3.0.CO;2-H }}
  • {{cite journal | vauthors = Gu J, Kawai H, Nie L, Kitao H, Wiederschain D, Jochemsen AG, Parant J, Lozano G, Yuan ZM | title = Mutual dependence of MDM2 and MDMX in their functional inactivation of p53 | journal = J. Biol. Chem. | volume = 277 | issue = 22 | pages = 19251–4 | year = 2002 | pmid = 11953423 | doi = 10.1074/jbc.C200150200 }}
  • {{cite journal | vauthors = Migliorini D, Lazzerini Denchi E, Danovi D, Jochemsen A, Capillo M, Gobbi A, Helin K, Pelicci PG, Marine JC | title = Mdm4 (Mdmx) regulates p53-induced growth arrest and neuronal cell death during early embryonic mouse development | journal = Mol. Cell. Biol. | volume = 22 | issue = 15 | pages = 5527–38 | year = 2002 | pmid = 12101245 | pmc = 133932 | doi = 10.1128/MCB.22.15.5527-5538.2002 }}
  • {{cite journal | vauthors = Wistow G, Bernstein SL, Wyatt MK, Fariss RN, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K | title = Expressed sequence tag analysis of human RPE/choroid for the NEIBank Project: over 6000 non-redundant transcripts, novel genes and splice variants | journal = Mol. Vis. | volume = 8 | issue = | pages = 205–20 | year = 2002 | pmid = 12107410 | doi = }}
  • {{cite journal | vauthors = Sabbatini P, McCormick F | title = MDMX inhibits the p300/CBP-mediated acetylation of p53 | journal = DNA Cell Biol. | volume = 21 | issue = 7 | pages = 519–25 | year = 2002 | pmid = 12162806 | doi = 10.1089/104454902320219077 }}
  • {{cite journal | vauthors = Li C, Chen L, Chen J | title = DNA damage induces MDMX nuclear translocation by p53-dependent and -independent mechanisms | journal = Mol. Cell. Biol. | volume = 22 | issue = 21 | pages = 7562–71 | year = 2002 | pmid = 12370303 | pmc = 135668 | doi = 10.1128/MCB.22.21.7562-7571.2002 }}
  • {{cite journal | vauthors = Badciong JC, Haas AL | title = MdmX is a RING finger ubiquitin ligase capable of synergistically enhancing Mdm2 ubiquitination | journal = J. Biol. Chem. | volume = 277 | issue = 51 | pages = 49668–75 | year = 2003 | pmid = 12393902 | doi = 10.1074/jbc.M208593200 }}
  • {{cite journal | vauthors = Kadakia M, Brown TL, McGorry MM, Berberich SJ | title = MdmX inhibits Smad transactivation | journal = Oncogene | volume = 21 | issue = 57 | pages = 8776–85 | year = 2003 | pmid = 12483531 | doi = 10.1038/sj.onc.1205993 }}
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