| 词条 | Meclocycline |
| 释义 |
| Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 407756887 | IUPAC_name = (2E,4S,4aR,5S,5aR,12aS)-2-[Amino(hydroxy)methylene]-7-chloro-4-(dimethylamino)-5,10,11,12a-tetrahydroxy-6-methylene-4a,5a,6,12a-tetrahydrotetracene-1,3,12(2H,4H,5H)-trione | image = Meclocycline.svg | alt = Skeletal formula of meclocycline | width = 240 | image2 = Meclocycline 3D ball.png | alt2 = Ball-and-stick model of the meclocycline molecule | tradename = | Drugs.com = {{drugs.com|CONS|meclocycline}} | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = Rx-only | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number_Ref = {{cascite|correct|??}} | CAS_number = 2013-58-3 | ATC_prefix = D10 | ATC_suffix = AF04 | ATC_supplemental = | PubChem = 54676539 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | UNII_Ref = {{fdacite|changed|FDA}} | UNII = 23Q8M2HE6S | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D02476 | ChEMBL_Ref = {{ebicite|changed|EBI}} | ChEMBL = 1237124 | ChemSpiderID_Ref = {{chemspidercite|changed|chemspider}} | ChemSpiderID = 16735890 | chemical_formula = | C=22 | H=21 | Cl=1 | N=2 | O=8 | molecular_weight = 476.86 g/mol | smiles = CN(C)[C@H]1[C@@H]2[C@H]([C@@H]3C(=C)C4=C(C=CC(=C4C(=O)C3=C([C@@]2(C(=O)C(=C1O)C(=O)N)O)O)O)Cl)O | StdInChI_Ref = {{stdinchicite|changed|chemspider}} | StdInChI = 1S/C22H21ClN2O8/c1-6-9-7(23)4-5-8(26)11(9)16(27)12-10(6)17(28)14-15(25(2)3)18(29)13(21(24)32)20(31)22(14,33)19(12)30/h4-5,10,14-15,17,26,28-30,33H,1H2,2-3H3,(H2,24,32)/t10-,14-,15+,17+,22+/m1/s1 | StdInChIKey_Ref = {{stdinchicite|changed|chemspider}} | StdInChIKey = GGQJXCQBBONZFX-IWVLMIASSA-N }} Meclocycline (INN) is a tetracycline antibiotic.[1] It is used topically (i.e. for skin infections) as it is totally insoluble in water and may cause liver and kidney damage if given systemically. Its production for medical use has been discontinued.[2] References1. ^{{cite web |title=Meclocycline sulfosalicylate |url=https://pubchem.ncbi.nlm.nih.gov/compound/Meclocycline_sulfosalicylate#section=Drug-and-Medication-Information |website=pubchem.ncbi.nlm.nih.gov |accessdate=3 January 2019 |language=en}} {{TetracyclineAntiBiotics}}{{antibiotic-stub}}{{dermatologic-drug-stub}}2. ^{{cite web |title=Orange Book: Approved Drug Products with Therapeutic Equivalence Evaluations |url=https://www.accessdata.fda.gov/scripts/cder/ob/results_product.cfm?Appl_Type=N&Appl_No=050518 |website=www.accessdata.fda.gov |accessdate=3 January 2019}} 3 : Chloroarenes|Tetracycline antibiotics|Triketones |
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