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词条 MED22
释义

  1. Function

  2. Interactions

  3. Model organisms

  4. References

  5. Further reading

{{Infobox_gene}}Mediator of RNA polymerase II transcription subunit 22 is an enzyme that in humans is encoded by the MED22 gene.[1][2][3]

Function

This gene is located in the surfeit gene cluster, a group of very tightly linked housekeeping genes that do not share sequence similarity. The gene is oriented in a head-to-head fashion with RPL7A (SURF3) and the two genes share a bidirectional promoter. The encoded proteins are localized to the cytoplasm. Two alternative transcript variants encoding different isoforms have been identified for this gene.[3]

Interactions

MED22 has been shown to interact with MED30.[4]

Model organisms

Model organisms have been used in the study of MED22 function. A conditional knockout mouse line called Med22tm1a(EUCOMM)Wtsi was generated at the Wellcome Trust Sanger Institute.[5] Male and female animals underwent a standardized phenotypic screen[6] to determine the effects of deletion.[7][8][9][10] Additional screens performed: - In-depth immunological phenotyping[11]{{clear}}

References

1. ^{{cite journal | vauthors = Yon J, Jones T, Garson K, Sheer D, Fried M | title = The organization and conservation of the human Surfeit gene cluster and its localization telomeric to the c-abl and can proto-oncogenes at chromosome band 9q34.1 | journal = Human Molecular Genetics | volume = 2 | issue = 3 | pages = 237–40 | date = Mar 1993 | pmid = 8499913 | pmc = | doi = 10.1093/hmg/2.3.237 }}
2. ^{{cite journal | vauthors = Sato S, Tomomori-Sato C, Parmely TJ, Florens L, Zybailov B, Swanson SK, Banks CA, Jin J, Cai Y, Washburn MP, Conaway JW, Conaway RC | title = A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology | journal = Molecular Cell | volume = 14 | issue = 5 | pages = 685–91 | date = Jun 2004 | pmid = 15175163 | pmc = | doi = 10.1016/j.molcel.2004.05.006 }}
3. ^1 {{cite web | title = Entrez Gene: SURF5 surfeit 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6837| accessdate = }}
4. ^{{cite journal | vauthors = Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, Jin J, Cai Y, Lane WS, Brower CS, Conaway RC, Conaway JW | title = Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 17 | pages = 15123–7 | date = Apr 2003 | pmid = 12584197 | doi = 10.1074/jbc.C300054200 }}
5. ^{{cite journal |title=The Sanger Mouse Genetics Programme: high throughput characterisation of knockout mice |author=Gerdin AK |year=2010 |doi=10.1111/j.1755-3768.2010.4142.x |volume=88 |journal=Acta Ophthalmologica}}
6. ^1 {{cite web |url=http://www.mousephenotype.org/data/search?q=Med22#fq=**&facet=gene |title=International Mouse Phenotyping Consortium}}
7. ^{{cite journal | vauthors = Skarnes WC, Rosen B, West AP, Koutsourakis M, Bushell W, Iyer V, Mujica AO, Thomas M, Harrow J, Cox T, Jackson D, Severin J, Biggs P, Fu J, Nefedov M, de Jong PJ, Stewart AF, Bradley A | title = A conditional knockout resource for the genome-wide study of mouse gene function | journal = Nature | volume = 474 | issue = 7351 | pages = 337–42 | date = Jun 2011 | pmid = 21677750 | pmc = 3572410 | doi = 10.1038/nature10163 }}
8. ^{{cite journal | vauthors = Dolgin E | title = Mouse library set to be knockout | journal = Nature | volume = 474 | issue = 7351 | pages = 262–3 | date = Jun 2011 | pmid = 21677718 | doi = 10.1038/474262a }}
9. ^{{cite journal | vauthors = Collins FS, Rossant J, Wurst W | title = A mouse for all reasons | journal = Cell | volume = 128 | issue = 1 | pages = 9–13 | date = Jan 2007 | pmid = 17218247 | doi = 10.1016/j.cell.2006.12.018 }}
10. ^{{cite journal | vauthors = White JK, Gerdin AK, Karp NA, Ryder E, Buljan M, Bussell JN, Salisbury J, Clare S, Ingham NJ, Podrini C, Houghton R, Estabel J, Bottomley JR, Melvin DG, Sunter D, Adams NC, Tannahill D, Logan DW, Macarthur DG, Flint J, Mahajan VB, Tsang SH, Smyth I, Watt FM, Skarnes WC, Dougan G, Adams DJ, Ramirez-Solis R, Bradley A, Steel KP | title = Genome-wide generation and systematic phenotyping of knockout mice reveals new roles for many genes | journal = Cell | volume = 154 | issue = 2 | pages = 452–64 | date = Jul 2013 | pmid = 23870131 | doi = 10.1016/j.cell.2013.06.022 | pmc=3717207}}
11. ^1 {{cite web |url= http://www.immunophenotyping.org/data/search?keys=Med22&field_gene_construct_tid=All |title=Infection and Immunity Immunophenotyping (3i) Consortium}}

Further reading

{{refbegin|33em}}
  • {{cite journal | vauthors = De Falco S, Russo G, Angiolillo A, Pietropaolo C | title = Human L7a ribosomal protein: sequence, structural organization, and expression of a functional gene | journal = Gene | volume = 126 | issue = 2 | pages = 227–35 | date = Apr 1993 | pmid = 8482538 | doi = 10.1016/0378-1119(93)90371-9 }}
  • {{cite journal | vauthors = Garson K, Duhig T, Armes N, Colombo P, Fried M | title = Surf5: a gene in the tightly clustered mouse surfeit locus is highly conserved and transcribed divergently from the rpL7A (Surf3) gene | journal = Genomics | volume = 30 | issue = 2 | pages = 163–70 | date = Nov 1995 | pmid = 8586415 | doi = 10.1006/geno.1995.9889 }}
  • {{cite journal | vauthors = Garson K, Duhig T, Fried M | title = Tissue-specific processing of the Surf-5 and Surf-4 mRNAs | journal = Gene Expression | volume = 6 | issue = 4 | pages = 209–18 | year = 1997 | pmid = 9196076 | pmc = 6148271 | doi = }}
  • {{cite journal | vauthors = Duhig T, Ruhrberg C, Mor O, Fried M | title = The human Surfeit locus | journal = Genomics | volume = 52 | issue = 1 | pages = 72–8 | date = Aug 1998 | pmid = 9740673 | doi = 10.1006/geno.1998.5372 }}
  • {{cite journal | vauthors = Angiolillo A, Russo G, Porcellini A, Smaldone S, D'Alessandro F, Pietropaolo C | title = The human homologue of the mouse Surf5 gene encodes multiple alternatively spliced transcripts | journal = Gene | volume = 284 | issue = 1–2 | pages = 169–78 | date = Feb 2002 | pmid = 11891058 | doi = 10.1016/S0378-1119(02)00379-7 }}
  • {{cite journal | vauthors = Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, Jin J, Cai Y, Lane WS, Brower CS, Conaway RC, Conaway JW | title = Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 17 | pages = 15123–7 | date = Apr 2003 | pmid = 12584197 | doi = 10.1074/jbc.C300054200 }}
  • {{cite journal | vauthors = Sato S, Tomomori-Sato C, Banks CA, Parmely TJ, Sorokina I, Brower CS, Conaway RC, Conaway JW | title = A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex | journal = The Journal of Biological Chemistry | volume = 278 | issue = 50 | pages = 49671–4 | date = Dec 2003 | pmid = 14576168 | doi = 10.1074/jbc.C300444200 }}
  • {{cite journal | vauthors = Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW | title = A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2 | journal = The Journal of Biological Chemistry | volume = 279 | issue = 7 | pages = 5846–51 | date = Feb 2004 | pmid = 14638676 | doi = 10.1074/jbc.M312523200 }}
  • {{cite journal | vauthors = Hillman RT, Green RE, Brenner SE | title = An unappreciated role for RNA surveillance | journal = Genome Biology | volume = 5 | issue = 2 | pages = R8 | year = 2005 | pmid = 14759258 | pmc = 395752 | doi = 10.1186/gb-2004-5-2-r8 }}
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