“MED30”的意思、由来-开放百科全书

Mediator of RNA polymerase II transcription subunit 30 is an enzyme that in humans is encoded by the MED30 gene.^[1] It represents subunit Med30 of the Mediator complex and is metazoan-specific,^[2] having no homologues in yeasts.

References

1. ^{{cite web | title = Entrez Gene: THRAP6 thyroid hormone receptor associated protein 6| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=90390| accessdate = }}
2. ^{{cite journal | vauthors = Baek HJ, Malik S, Qin J, Roeder RG | title = Requirement of TRAP/mediator for both activator-independent and activator-dependent transcription in conjunction with TFIID-associated TAF(II)s | journal = Molecular and Cellular Biology | volume = 22 | issue = 8 | pages = 2842–52 | date = Apr 2002 | pmid = 11909976 | pmc = 133729 | doi = 10.1128/MCB.22.8.2842-2852.2002 }}
3. ^{{cite journal | vauthors = Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, Jin J, Cai Y, Lane WS, Brower CS, Conaway RC, Conaway JW | title = Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 17 | pages = 15123–7 | date = Apr 2003 | pmid = 12584197 | doi = 10.1074/jbc.C300054200 }}

Further reading

{{cite journal | vauthors = Sato S, Tomomori-Sato C, Parmely TJ, Florens L, Zybailov B, Swanson SK, Banks CA, Jin J, Cai Y, Washburn MP, Conaway JW, Conaway RC | title = A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology | journal = Molecular Cell | volume = 14 | issue = 5 | pages = 685–91 | date = Jun 2004 | pmid = 15175163 | doi = 10.1016/j.molcel.2004.05.006 }}

{{cite journal | vauthors = Tomomori-Sato C, Sato S, Parmely TJ, Banks CA, Sorokina I, Florens L, Zybailov B, Washburn MP, Brower CS, Conaway RC, Conaway JW | title = A mammalian mediator subunit that shares properties with Saccharomyces cerevisiae mediator subunit Cse2 | journal = The Journal of Biological Chemistry | volume = 279 | issue = 7 | pages = 5846–51 | date = Feb 2004 | pmid = 14638676 | doi = 10.1074/jbc.M312523200 }}

{{cite journal | vauthors = Sato S, Tomomori-Sato C, Banks CA, Parmely TJ, Sorokina I, Brower CS, Conaway RC, Conaway JW | title = A mammalian homolog of Drosophila melanogaster transcriptional coactivator intersex is a subunit of the mammalian Mediator complex | journal = The Journal of Biological Chemistry | volume = 278 | issue = 50 | pages = 49671–4 | date = Dec 2003 | pmid = 14576168 | doi = 10.1074/jbc.C300444200 }}

{{cite journal | vauthors = Sato S, Tomomori-Sato C, Banks CA, Sorokina I, Parmely TJ, Kong SE, Jin J, Cai Y, Lane WS, Brower CS, Conaway RC, Conaway JW | title = Identification of mammalian Mediator subunits with similarities to yeast Mediator subunits Srb5, Srb6, Med11, and Rox3 | journal = The Journal of Biological Chemistry | volume = 278 | issue = 17 | pages = 15123–7 | date = Apr 2003 | pmid = 12584197 | doi = 10.1074/jbc.C300054200 }}

{{cite journal | vauthors = Wang Q, Sharma D, Ren Y, Fondell JD | title = A coregulatory role for the TRAP-mediator complex in androgen receptor-mediated gene expression | journal = The Journal of Biological Chemistry | volume = 277 | issue = 45 | pages = 42852–8 | date = Nov 2002 | pmid = 12218053 | doi = 10.1074/jbc.M206061200 }}

{{cite journal | vauthors = Kutsenko AS, Gizatullin RZ, Al-Amin AN, Wang F, Kvasha SM, Podowski RM, Matushkin YG, Gyanchandani A, Muravenko OV, Levitsky VG, Kolchanov NA, Protopopov AI, Kashuba VI, Kisselev LL, Wasserman W, Wahlestedt C, Zabarovsky ER | title = NotI flanking sequences: a tool for gene discovery and verification of the human genome | journal = Nucleic Acids Research | volume = 30 | issue = 14 | pages = 3163–70 | date = Jul 2002 | pmid = 12136098 | pmc = 135748 | doi = 10.1093/nar/gkf428 }}

{{cite journal | vauthors = Baek HJ, Malik S, Qin J, Roeder RG | title = Requirement of TRAP/mediator for both activator-independent and activator-dependent transcription in conjunction with TFIID-associated TAF(II)s | journal = Molecular and Cellular Biology | volume = 22 | issue = 8 | pages = 2842–52 | date = Apr 2002 | pmid = 11909976 | pmc = 133729 | doi = 10.1128/MCB.22.8.2842-2852.2002 }}

{{cite journal | vauthors = Suzuki H, Fukunishi Y, Kagawa I, Saito R, Oda H, Endo T, Kondo S, Bono H, Okazaki Y, Hayashizaki Y | title = Protein-protein interaction panel using mouse full-length cDNAs | journal = Genome Research | volume = 11 | issue = 10 | pages = 1758–65 | date = Oct 2001 | pmid = 11591653 | pmc = 311163 | doi = 10.1101/gr.180101 }}

{{cite journal | vauthors = Näär AM, Beaurang PA, Zhou S, Abraham S, Solomon W, Tjian R | title = Composite co-activator ARC mediates chromatin-directed transcriptional activation | journal = Nature | volume = 398 | issue = 6730 | pages = 828–32 | date = Apr 1999 | pmid = 10235267 | doi = 10.1038/19789 }}

{{cite journal | vauthors = Rachez C, Lemon BD, Suldan Z, Bromleigh V, Gamble M, Näär AM, Erdjument-Bromage H, Tempst P, Freedman LP | title = Ligand-dependent transcription activation by nuclear receptors requires the DRIP complex | journal = Nature | volume = 398 | issue = 6730 | pages = 824–8 | date = Apr 1999 | pmid = 10235266 | doi = 10.1038/19783 }}

{{cite journal | vauthors = Ito M, Yuan CX, Malik S, Gu W, Fondell JD, Yamamura S, Fu ZY, Zhang X, Qin J, Roeder RG | title = Identity between TRAP and SMCC complexes indicates novel pathways for the function of nuclear receptors and diverse mammalian activators | journal = Molecular Cell | volume = 3 | issue = 3 | pages = 361–70 | date = Mar 1999 | pmid = 10198638 | doi = 10.1016/S1097-2765(00)80463-3 }}

1 : Protein domains

Interactions

References

Further reading