| 释义 |
- Interactions
- See also
- References
- Further reading
- External links
{{Infobox_gene}}Myocyte-specific enhancer factor 2D is a protein that in humans is encoded by the MEF2D gene.[1][2] Interactions MEF2D has been shown to interact with: {{div col|colwidth=20em}}- CABIN1,[3][3]
- EP300,[4][5]
- MAPK7,[6]
- Myocyte-specific enhancer factor 2A,[7]
- NFATC2[8]
- Sp1 transcription factor,[9] and
- YWHAQ.[10]
{{Div col end}} See also References 1. ^{{cite journal | vauthors = Breitbart RE, Liang CS, Smoot LB, Laheru DA, Mahdavi V, Nadal-Ginard B | title = A fourth human MEF2 transcription factor, hMEF2D, is an early marker of the myogenic lineage | journal = Development | volume = 118 | issue = 4 | pages = 1095–106 | date = Aug 1993 | pmid = 8269842 | pmc = | doi = }}
2. ^{{cite web | title = Entrez Gene: MEF2D MADS box transcription enhancer factor 2, polypeptide D (myocyte enhancer factor 2D)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4209| accessdate = }}
3. ^{{cite journal | vauthors = Youn HD, Sun L, Prywes R, Liu JO | title = Apoptosis of T cells mediated by Ca2+-induced release of the transcription factor MEF2 | journal = Science | volume = 286 | issue = 5440 | pages = 790–3 | date = Oct 1999 | pmid = 10531067 | doi = 10.1126/science.286.5440.790}}
4. ^{{cite journal | vauthors = Youn HD, Grozinger CM, Liu JO | title = Calcium regulates transcriptional repression of myocyte enhancer factor 2 by histone deacetylase 4 | journal = The Journal of Biological Chemistry | volume = 275 | issue = 29 | pages = 22563–7 | date = Jul 2000 | pmid = 10825153 | doi = 10.1074/jbc.C000304200 }}
5. ^1 {{cite journal | vauthors = Youn HD, Liu JO | title = Cabin1 represses MEF2-dependent Nur77 expression and T cell apoptosis by controlling association of histone deacetylases and acetylases with MEF2 | journal = Immunity | volume = 13 | issue = 1 | pages = 85–94 | date = Jul 2000 | pmid = 10933397 | doi = 10.1016/s1074-7613(00)00010-8}}
6. ^{{cite journal | vauthors = Yang CC, Ornatsky OI, McDermott JC, Cruz TF, Prody CA | title = Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1 | journal = Nucleic Acids Research | volume = 26 | issue = 20 | pages = 4771–7 | date = Oct 1998 | pmid = 9753748 | pmc = 147902 | doi = 10.1093/nar/26.20.4771}}
7. ^{{cite journal | vauthors = Ornatsky OI, McDermott JC | title = MEF2 protein expression, DNA binding specificity and complex composition, and transcriptional activity in muscle and non-muscle cells | journal = The Journal of Biological Chemistry | volume = 271 | issue = 40 | pages = 24927–33 | date = Oct 1996 | pmid = 8798771 | doi = 10.1074/jbc.271.40.24927}}
8. ^{{cite journal | vauthors = Youn HD, Chatila TA, Liu JO | title = Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis | journal = The EMBO Journal | volume = 19 | issue = 16 | pages = 4323–31 | date = Aug 2000 | pmid = 10944115 | pmc = 302027 | doi = 10.1093/emboj/19.16.4323 }}
9. ^{{cite journal | vauthors = Park SY, Shin HM, Han TH | title = Synergistic interaction of MEF2D and Sp1 in activation of the CD14 promoter | journal = Molecular Immunology | volume = 39 | issue = 1–2 | pages = 25–30 | date = Sep 2002 | pmid = 12213324 | doi = 10.1016/s0161-5890(02)00055-x}}
10. ^{{cite journal | vauthors = Choi SJ, Park SY, Han TH | title = 14-3-3tau associates with and activates the MEF2D transcription factor during muscle cell differentiation | journal = Nucleic Acids Research | volume = 29 | issue = 13 | pages = 2836–42 | date = Jul 2001 | pmid = 11433030 | pmc = 55772 | doi = 10.1093/nar/29.13.2836}}
Further reading {{refbegin|33em}}- {{cite journal | vauthors = Hobson GM, Krahe R, Garcia E, Siciliano MJ, Funanage VL | title = Regional chromosomal assignments for four members of the MADS domain transcription enhancer factor 2 (MEF2) gene family to human chromosomes 15q26, 19p12, 5q14, and 1q12-q23 | journal = Genomics | volume = 29 | issue = 3 | pages = 704–11 | date = Oct 1995 | pmid = 8575763 | doi = 10.1006/geno.1995.9007 }}
- {{cite journal | vauthors = Ornatsky OI, McDermott JC | title = MEF2 protein expression, DNA binding specificity and complex composition, and transcriptional activity in muscle and non-muscle cells | journal = The Journal of Biological Chemistry | volume = 271 | issue = 40 | pages = 24927–33 | date = Oct 1996 | pmid = 8798771 | doi = 10.1074/jbc.271.40.24927 }}
- {{cite journal | vauthors = Yang CC, Ornatsky OI, McDermott JC, Cruz TF, Prody CA | title = Interaction of myocyte enhancer factor 2 (MEF2) with a mitogen-activated protein kinase, ERK5/BMK1 | journal = Nucleic Acids Research | volume = 26 | issue = 20 | pages = 4771–7 | date = Oct 1998 | pmid = 9753748 | pmc = 147902 | doi = 10.1093/nar/26.20.4771 }}
- {{cite journal | vauthors = Zhao M, New L, Kravchenko VV, Kato Y, Gram H, di Padova F, Olson EN, Ulevitch RJ, Han J | title = Regulation of the MEF2 family of transcription factors by p38 | journal = Molecular and Cellular Biology | volume = 19 | issue = 1 | pages = 21–30 | date = Jan 1999 | pmid = 9858528 | pmc = 83862 | doi = 10.1128/mcb.19.1.21 }}
- {{cite journal | vauthors = Wang AH, Bertos NR, Vezmar M, Pelletier N, Crosato M, Heng HH, Th'ng J, Han J, Yang XJ | title = HDAC4, a human histone deacetylase related to yeast HDA1, is a transcriptional corepressor | journal = Molecular and Cellular Biology | volume = 19 | issue = 11 | pages = 7816–27 | date = Nov 1999 | pmid = 10523670 | pmc = 84849 | doi = 10.1128/mcb.19.11.7816 }}
- {{cite journal | vauthors = Lu J, McKinsey TA, Nicol RL, Olson EN | title = Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 8 | pages = 4070–5 | date = Apr 2000 | pmid = 10737771 | pmc = 18151 | doi = 10.1073/pnas.080064097 }}
- {{cite journal | vauthors = Kato Y, Zhao M, Morikawa A, Sugiyama T, Chakravortty D, Koide N, Yoshida T, Tapping RI, Yang Y, Yokochi T, Lee JD | title = Big mitogen-activated kinase regulates multiple members of the MEF2 protein family | journal = The Journal of Biological Chemistry | volume = 275 | issue = 24 | pages = 18534–40 | date = Jun 2000 | pmid = 10849446 | doi = 10.1074/jbc.M001573200 }}
- {{cite journal | vauthors = Youn HD, Chatila TA, Liu JO | title = Integration of calcineurin and MEF2 signals by the coactivator p300 during T-cell apoptosis | journal = The EMBO Journal | volume = 19 | issue = 16 | pages = 4323–31 | date = Aug 2000 | pmid = 10944115 | pmc = 302027 | doi = 10.1093/emboj/19.16.4323 }}
- {{cite journal | vauthors = Slepak TI, Webster KA, Zang J, Prentice H, O'Dowd A, Hicks MN, Bishopric NH | title = Control of cardiac-specific transcription by p300 through myocyte enhancer factor-2D | journal = The Journal of Biological Chemistry | volume = 276 | issue = 10 | pages = 7575–85 | date = Mar 2001 | pmid = 11096067 | doi = 10.1074/jbc.M004625200 }}
- {{cite journal | vauthors = Choi SJ, Park SY, Han TH | title = 14-3-3tau associates with and activates the MEF2D transcription factor during muscle cell differentiation | journal = Nucleic Acids Research | volume = 29 | issue = 13 | pages = 2836–42 | date = Jul 2001 | pmid = 11433030 | pmc = 55772 | doi = 10.1093/nar/29.13.2836 }}
- {{cite journal | vauthors = Okamoto S, Li Z, Ju C, Scholzke MN, Mathews E, Cui J, Salvesen GS, Bossy-Wetzel E, Lipton SA | title = Dominant-interfering forms of MEF2 generated by caspase cleavage contribute to NMDA-induced neuronal apoptosis | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 99 | issue = 6 | pages = 3974–9 | date = Mar 2002 | pmid = 11904443 | pmc = 122633 | doi = 10.1073/pnas.022036399 }}
- {{cite journal | vauthors = Park SY, Shin HM, Han TH | title = Synergistic interaction of MEF2D and Sp1 in activation of the CD14 promoter | journal = Molecular Immunology | volume = 39 | issue = 1–2 | pages = 25–30 | date = Sep 2002 | pmid = 12213324 | doi = 10.1016/S0161-5890(02)00055-X }}
- {{cite journal | vauthors = Linseman DA, Bartley CM, Le SS, Laessig TA, Bouchard RJ, Meintzer MK, Li M, Heidenreich KA | title = Inactivation of the myocyte enhancer factor-2 repressor histone deacetylase-5 by endogenous Ca(2+) //calmodulin-dependent kinase II promotes depolarization-mediated cerebellar granule neuron survival | journal = The Journal of Biological Chemistry | volume = 278 | issue = 42 | pages = 41472–81 | date = Oct 2003 | pmid = 12896970 | doi = 10.1074/jbc.M307245200 }}
- {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5 | date = Aug 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
- {{cite journal | vauthors = Grégoire S, Yang XJ | title = Association with class IIa histone deacetylases upregulates the sumoylation of MEF2 transcription factors | journal = Molecular and Cellular Biology | volume = 25 | issue = 6 | pages = 2273–87 | date = Mar 2005 | pmid = 15743823 | pmc = 1061617 | doi = 10.1128/MCB.25.6.2273-2287.2005 }}
- {{cite journal | vauthors = Prima V, Gore L, Caires A, Boomer T, Yoshinari M, Imaizumi M, Varella-Garcia M, Hunger SP | title = Cloning and functional characterization of MEF2D/DAZAP1 and DAZAP1/MEF2D fusion proteins created by a variant t(1;19)(q23;p13.3) in acute lymphoblastic leukemia | journal = Leukemia | volume = 19 | issue = 5 | pages = 806–13 | date = May 2005 | pmid = 15744350 | doi = 10.1038/sj.leu.2403684 }}
{{refend}} External links - {{MeshName|MEF2D+protein,+human}}
{{PDB Gallery|geneid=4209}}{{Transcription factors|g4}} 1 : Transcription factors |