| 释义 |
- Clinical significance
- See also
- References
- External links
- Further reading
{{Infobox gene}}Melanin-concentrating hormone receptor 2 (MCH2) also known as G-protein coupled receptor 145 (GPR145) is a protein that in humans is encoded by the MCHR2 gene.[1][2][3]MCH2 is also found in dogs, ferrets, and some other primates and carnivores, but is not found in mice or rats. This has delayed research into the receptor as a therapeutic target, due to most early pharmaceutical research usually being conducted in small mammals such as mice, rats or rabbits which lack the MCH2 gene and its receptor product. Clinical significanceTreatment of human cells expressing MCHR2 with MCH resulted in upregulation of IDH3A, PCK1 and PFKFB4 and the downregulation of INSIG2 and ACOT8.[4] See also- Melanin-concentrating hormone receptor
References1. ^{{cite web | title = Entrez Gene: MCHR2 melanin-concentrating hormone receptor 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=84539| accessdate = }}
2. ^{{cite journal |vauthors=Mori M, Harada M, Terao Y, Sugo T, Watanabe T, Shimomura Y, Abe M, Shintani Y, Onda H, Nishimura O, Fujino M | title = Cloning of a novel G protein-coupled receptor, SLT, a subtype of the melanin-concentrating hormone receptor | journal = Biochem. Biophys. Res. Commun. | volume = 283 | issue = 5 | pages = 1013–8 |date=May 2001 | pmid = 11355873 | doi = 10.1006/bbrc.2001.4893 }}
3. ^{{cite journal |vauthors=Hill J, Duckworth M, Murdock P, Rennie G, Sabido-David C, Ames RS, Szekeres P, Wilson S, Bergsma DJ, Gloger IS, Levy DS, Chambers JK, Muir AI | title = Molecular cloning and functional characterization of MCH2, a novel human MCH receptor | journal = J. Biol. Chem. | volume = 276 | issue = 23 | pages = 20125–9 |date=June 2001 | pmid = 11274220 | doi = 10.1074/jbc.M102068200 }}
4. ^{{cite journal |vauthors=Zhang Q, Yuan CF, Wu MJ, Wang YG, Qin Q, Shi YY, Liu GL, Song FZ | title = Comparative proteomic analysis of proteins influenced by melanin-concentrating hormone and melanin-concentrating hormone receptor 2 interaction | journal = Horm. Metab. Res. | volume = 42 | issue = 7 | pages = 521–7 |date=June 2010 | pmid = 20340065 | doi = 10.1055/s-0030-1249019 }}
External links- {{cite web | url = http://www.iuphar-db.org/GPCR/ReceptorDisplayForward?receptorID=2999 | title = Melanin-Concentrating Hormone Receptors: MCH2 | accessdate = | date = | format = | work = IUPHAR Database of Receptors and Ion Channels | publisher = International Union of Basic and Clinical Pharmacology | pages = | language = | archiveurl = | archivedate = | quote = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Sailer AW, Sano H, Zeng Z, etal |title=Identification and characterization of a second melanin-concentrating hormone receptor, MCH-2R. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 13 |pages= 7564–9 |year= 2001 |pmid= 11404457 |doi= 10.1073/pnas.121170598 | pmc=34708 }}
- {{cite journal |vauthors=An S, Cutler G, Zhao JJ, etal |title=Identification and characterization of a melanin-concentrating hormone receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 13 |pages= 7576–81 |year= 2001 |pmid= 11416225 |doi= 10.1073/pnas.131200698 | pmc=34710 }}
- {{cite journal |vauthors=Wang S, Behan J, O'Neill K, etal |title=Identification and pharmacological characterization of a novel human melanin-concentrating hormone receptor, mch-r2. |journal=J. Biol. Chem. |volume=276 |issue= 37 |pages= 34664–70 |year= 2001 |pmid= 11459838 |doi= 10.1074/jbc.M102601200 }}
- {{cite journal |vauthors=Bednarek MA, Feighner SD, Hreniuk DL, etal |title=Short segment of human melanin-concentrating hormone that is sufficient for full activation of human melanin-concentrating hormone receptors 1 and 2. |journal=Biochemistry |volume=40 |issue= 31 |pages= 9379–86 |year= 2001 |pmid= 11478907 |doi=10.1021/bi010867p }}
- {{cite journal |vauthors=Bednarek MA, Tan C, Hreniuk DL, etal |title=Synthesis and biological evaluation in vitro of a selective, high potency peptide agonist of human melanin-concentrating hormone action at human melanin-concentrating hormone receptor 1. |journal=J. Biol. Chem. |volume=277 |issue= 16 |pages= 13821–6 |year= 2002 |pmid= 11839762 |doi= 10.1074/jbc.M200563200 }}
- {{cite journal |vauthors=Audinot V, Lahaye C, Suply T, etal |title=SVK14 cells express an MCH binding site different from the MCH1 or MCH2 receptor. |journal=Biochem. Biophys. Res. Commun. |volume=295 |issue= 4 |pages= 841–8 |year= 2002 |pmid= 12127971 |doi=10.1016/S0006-291X(02)00763-5 }}
- {{cite journal |vauthors=Logan DW, Bryson-Richardson RJ, Pagán KE, etal |title=The structure and evolution of the melanocortin and MCH receptors in fish and mammals. |journal=Genomics |volume=81 |issue= 2 |pages= 184–91 |year= 2003 |pmid= 12620396 |doi=10.1016/S0888-7543(02)00037-X }}
- {{cite journal |vauthors=Vitale RM, Pedone C, De Benedetti PG, Fanelli F |title=Structural features of the inactive and active states of the melanin-concentrating hormone receptors: insights from molecular simulations. |journal=Proteins |volume=56 |issue= 3 |pages= 430–48 |year= 2004 |pmid= 15229878 |doi= 10.1002/prot.20125 }}
- {{cite journal |vauthors=Hawes BE, Green B, O'Neill K, etal |title=Identification and characterization of single-nucleotide polymorphisms in MCH-R1 and MCH-R2. |journal=Obes. Res. |volume=12 |issue= 8 |pages= 1327–34 |year= 2004 |pmid= 15340116 |doi=10.1038/oby.2004.167 }}
{{refend}}{{G protein-coupled receptors}}{{Neuropeptidergics}}{{transmembranereceptor-stub}} 2 : G protein-coupled receptors|Human proteins |