| 词条 | Melarsomine |
| 释义 |
| verifiedrevid = 444367111 | IUPAC_name = Bis(2-aminoethyl) {4-[(4,6-diamino-1,3,5-triazin-2-yl)amino]phenyl}arsonodithioite | image = melaminylthioarsenate.png | alt = Skeletal formula of melarsomine | width = 240 | image2 = Melarsomine 3D spacefill.png | alt2 = Space-filling model of the melarsomine molecule | tradename = Immiticide, Diroban | Drugs.com = {{drugs.com|international|melarsomine}} | pregnancy_AU = | pregnancy_US = | pregnancy_category = | legal_AU = | legal_CA = | legal_UK = | legal_US = | legal_status = | routes_of_administration = | bioavailability = | protein_bound = | metabolism = | elimination_half-life = | excretion = | CAS_number = 128470-15-5 | ATC_prefix = none | ATC_suffix = | PubChem = 65962 | DrugBank_Ref = {{drugbankcite|correct|drugbank}} | DrugBank = | UNII_Ref = {{fdacite|correct|FDA}} | UNII = 374GJ0S41A | KEGG_Ref = {{keggcite|correct|kegg}} | KEGG = D08168 | ChemSpiderID = 59365 | chemical_formula = | C=13 | H=21 | As=1 | N=8 | S=2 | molecular_weight = 428.41 g/mol | smiles = C1=CC(=CC=C1NC2=NC(=NC(=N2)N)N)[As](SCCN)SCCN | StdInChI = 1S/C13H21AsN8S2/c15-5-7-23-14(24-8-6-16)9-1-3-10(4-2-9)19-13-21-11(17)20-12(18)22-13/h1-4H,5-8,15-16H2,(H5,17,18,19,20,21,22) | StdInChIKey = MGEOLZFMLHYCFZ-UHFFFAOYSA-N }}Melarsomine (melaminylthioarsenate) is a trypanocidal agent. In the U.S., it is marketed under the trade names Immiticide (Merial) and Diroban (Zoetis), and is approved by the FDA's Center for Veterinary Medicine for the treatment of adult heartworm (Dirofilaria immitis) infection in dogs. It is not approved for treatment in cats, or dogs in late-stage infection.[1][2] References1. ^{{cite book|last1=Tilley|first1=Lawrence P.|title=Manual of Canine and Feline Cardiology|url=https://books.google.com/books?id=nggxUPtJsAYC&pg=PA196|year=2008|publisher=Elsevier Health Sciences|isbn=1-4160-2398-4|pages=194–197}} 2. ^{{cite book|last1=Bonagura|first1=John D. |last2=Twedt|first2=David C.|title=Kirk's Current Veterinary Therapy XV|url=https://books.google.com/books?id=KlJKAgAAQBAJ&pg=PT2502|year=2013|publisher=Elsevier Health Sciences|isbn=978-0-323-22762-9|page=2502}} External links
5 : Antiparasitic agents|Organoarsenic dithiolates|Triazines|Organosulfur compounds|Drugs with unknown mechanisms of action |
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