请输入您要查询的百科知识：

　

词条 Lewy body dementia
释义

  1. Signs and symptoms

  2. Diagnosis

  3. Pathophysiology

  4. Epidemiology

  5. Society and culture

     Advocacy and awareness  Notable individuals  In film 

  6. References

  7. External links

{{Distinguish|text = dementia with Lewy bodies, one of the Lewy body dementias, along with Parkinson's disease dementia}}Lewy body dementia (LBD, sometimes referred to as Lewy body disorder) is an umbrella term[1] that includes Parkinson's disease dementia (PDD) and dementia with Lewy bodies (DLB), two dementias characterized by abnormal deposits of the protein alpha-synuclein in the brain.[2][3][4]

Signs and symptoms

{{See|Dementia with Lewy bodies#Signs and symptoms}}

The synucleinopathies (DLB, PDD and Parkinson's disease) have shared features of parkinsonism, impaired cognition, sleep disorders, and visual hallucinations.[3] A core feature is REM sleep behavior disorder (RBD), in which individuals lose normal muscle paralysis during REM sleep, and act out their dreams.[6][5] Other frequent symptoms include visual hallucinations; marked fluctuations in attention or alertness; and slowness of movement, trouble walking, or rigidity.[6] The autonomic nervous system is usually affected, and can result in symptoms like changes in blood pressure, heart and gastrointestinal function, and constipation.[6] Mood changes such as depression and apathy are common.[7]

REM sleep behavior disorder may appear decades before any other symptoms.[8] On autopsy, 94 to 98% of individuals with polysomnography-confirmed RBD are found to have a synucleinopathy—most commonly DLB or Parkinson's disease,[9][10][11] in about equal proportions.[12] Other symptoms of the specific synucleinopathy usually manifest within 15 years of the diagnosis of RBD,[13] but may emerge up to 50 years after RBD diagnosis.[9]

Diagnosis

{{See|Dementia with Lewy bodies#Diagnosis}}

Dementia with Lewy bodies is distinguished from Parkinson's disease dementia by the time frame in which dementia symptoms appear relative to parkinsonian symptoms. DLB is diagnosed when cognitive symptoms begin before or at the same time as parkinsonism, while PDD is the diagnosis when Parkinson's disease is well established before the dementia occurs.[7]

Pathophysiology

{{See|Dementia with Lewy bodies#Pathophysiology}}

Dementia with Lewy bodies and Parkinson's disease dementia are similar in many ways, suggesting there may be a common pathophysiological mechanism, with PDD and DLB at opposite ends of a LBD spectrum, and a shared component of protein deposits in Lewy bodies and Lewy neurites.[14] Despite differences in the timing of the appearance of symptoms, the two dementias "show remarkably convergent neuropathological changes at autopsy".[2]

Epidemiology

The Lewy body dementias affect about 1.3 million people in the US and 140,000 in the UK.[15] LBD usually develops after the age of 50.[16]

Society and culture

Advocacy and awareness

Lewy body dementias are more often misdiagnosed than any other common dementia.[15] Most people with DLB had not heard of the condition prior to diagnosis; general awareness about LBD lags well behind that of Parkinson's and Alzheimer's diseases, even though LBD is the second most common dementia, after Alzheimer's.[17] It is not only frustrating for families and caregivers to find that few people, including many healthcare professionals, are knowledgeable about LBD; lack of knowledge can have significant health consequences because people with LBD have severe sensitivity to antipsychotics often used to treat the symptoms.[15] The Lewy Body Dementia Association (LBDA) and the Lewy Body Society promote awareness and provide support that helps society, by reducing costly use of healthcare, and families with LBD, by reducing stress.[15] These organizations, and others in Argentina, Australia and Japan, help raise knowledge and help families with LBD become advocates to raise awareness about the disease.[15]

Notable individuals

{{further|List of people diagnosed with Parkinson's disease}}

The British author and poet Mervyn Peake died in 1968 and was diagnosed posthumously as a probable case of DLB in a 2003 paper published in JAMA Neurology.[18] Sahlas said his death was "variously ascribed to Alzheimer disease, Parkinson disease, or postencephalitic parkinsonism".[18] Based on signs in his work and letters of progressive deterioration, fluctuating cognitive decline, deterioration in visuospatial function, declining attention span, and visual hallucinations and delusions, his may be the earliest known case where DLB was found to have been the likely cause of death.[18]

Robin Williams, the American actor and comedian, committed suicide on August 11, 2014. He had been diagnosed with Parkinson's disease,[19] and according to his widow he experienced depression, anxiety, and increasing paranoia.[20] Upon autopsy his widow said he was found to have diffuse DLB.[21] Ian G. McKeith, a dementia researcher and professor of old age psychiatry, commented that DLB was still too little known, and that Williams' symptoms were explained by DLB.[22] The LBDA clarified the distinction between the term used in the autopsy report, diffuse Lewy body dementia, which is more commonly called diffuse Lewy body disease and refers to the underlying disease process, and the umbrella term, Lewy body dementia, which encompasses both PDD and DLB.[23] According to Dennis Dickson, the LBDA spokesperson, "The report confirms he experienced depression, anxiety and paranoia, which may occur in either Parkinson's disease or dementia with Lewy bodies," adding that, in Parkinson's, "Lewy bodies are generally limited in distribution, but in DLB, the Lewy bodies are spread widely throughout the brain, as was the case with Robin Williams."[23]

Other entertainers and artists who had or died from LBD include Estelle Getty, an actress known for her role in the television series The Golden Girls,[24] Nicholas King, a US actor and horticulturist,[25] actress Dina Merrill,[26] Donald Featherstone, who created the plastic pink flamingo,[27] American radio and television host Casey Kasem,[28] and Canadian singer Pierre Lalonde.[29][30]

Individuals from industry or government who had or died from LBD are Seymour Berry, US Director of the Bureau of Engraving and Printing,[31] Los Angeles Times publisher Otis Chandler,[32] Philip J. Rock,

a US Democratic politician of the Illinois Senate,[33] and U.S. media mogul and philanthropist Ted Turner.[34]

Arnold R. Hirsch, a US historian who taught at the University of New Orleans,[35] and Jessie Isabelle Price, a US veterinary microbiologist[36] died from LBD.

In the sports realm, Stan Mikita, Canadian ice hockey player,[37] and Jerry Sloan, American professional basketball player and coach,[38] have been diagnosed with DLB. Andy Carey was a US Major League Baseball player for the New York Yankees who died from LBD.[39]

In film

Hand of God, the Amazon Prime series, deals with a judge who claims to have this type of dementia.

Sleepwalk with Me is a book, one-man comedy, and film about a young man with relationship problems and REM sleep behavior disorder, a precursor to synucleinopathy, including LBD.[40]

References

1. ^{{cite journal |vauthors=Walker Z, Possin KL, Boeve BF, Aarsland D |title=Lewy body dementias |journal=Lancet |volume=386 |issue=10004 |pages=1683–97 |date=October 2015 |pmid=26595642 |pmc=5792067 |doi=10.1016/S0140-6736(15)00462-6 |type=Review}}
2. ^1 {{cite journal |vauthors=Gomperts SN |title=Lewy Body Dementias: Dementia With Lewy Bodies and Parkinson Disease Dementia |journal=Continuum (Minneap Minn) |volume=22 |issue=2 Dementia |pages=435–63 |date=April 2016 |pmid=27042903 |pmc=5390937 |doi=10.1212/CON.0000000000000309}}
3. ^1 {{cite journal |vauthors=Pezzoli S, Cagnin A, Bandmann O, Venneri A |title=Structural and Functional Neuroimaging of Visual Hallucinations in Lewy Body Disease: A Systematic Literature Review |journal=Brain Sci |volume=7 |issue=7 |pages= 84|date=July 2017 |pmid=28714891 |pmc=5532597 |doi=10.3390/brainsci7070084 }}
4. ^{{cite journal |vauthors=Galasko D |title=Lewy Body Disorders |journal=Neurol Clin |volume=35 |issue=2 |pages=325–338 |date=May 2017 |pmid=28410662 |pmc=5912679 |doi=10.1016/j.ncl.2017.01.004 }}
5. ^{{cite journal |vauthors=St Louis EK, Boeve AR, Boeve BF |title=REM sleep behavior disorder in Parkinson's disease and other synucleinopathies |journal=Mov. Disord. |volume=32 |issue=5 |pages=645–58 |date=May 2017 |pmid=28513079 |doi=10.1002/mds.27018|type=Review }}
6. ^ {{cite journal |vauthors=Palma JA, Kaufmann H |title=Treatment of autonomic dysfunction in Parkinson disease and other synucleinopathies |journal=Mov. Disord. |volume=33 |issue=3 |pages=372–90 |date=March 2018 |pmid=29508455 |pmc=5844369 |doi=10.1002/mds.27344 |type=Review}}
7. ^1 2 3 {{cite journal |vauthors=McKeith IG, Boeve BF, Dickson DW, et al |title=Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium |journal=Neurology |volume=89 |issue=1 |pages=88–100 |date=July 2017 |pmid=28592453 |pmc=5496518 |doi=10.1212/WNL.0000000000004058 |type=Review }}
8. ^{{cite journal |vauthors=St Louis EK, Boeve AR, Boeve BF |title=REM sleep behavior disorder in Parkinson's disease and other synucleinopathies |journal=Mov. Disord. |volume=32 |issue=5 |pages=645–58 |date=May 2017 |pmid=28513079 |doi=10.1002/mds.27018|type=Review }}
9. ^1 {{cite journal |vauthors=St Louis EK, Boeve BF |title=REM sleep behavior disorder: Diagnosis, clinical implications, and future directions |journal=Mayo Clin. Proc. |volume=92 |issue=11 |pages=1723–36 |date=November 2017 |pmid=29101940 |pmc=6095693 |doi=10.1016/j.mayocp.2017.09.007 |type=Review |url=http://www.mayoclinicproceedings.org/article/S0025-6196(17)30688-2/fulltext}}
10. ^{{cite journal |vauthors=Boot BP, McDade EM, McGinnis SM, Boeve BF |title=Treatment of dementia with Lewy bodies |journal=Curr Treat Options Neurol |volume=15 |issue=6 |pages=738–64 |date=December 2013 |pmid=24222315 |pmc=3913181 |doi=10.1007/s11940-013-0261-6 |type=Review}}
11. ^{{cite journal |vauthors=Boot BP |title=Comprehensive treatment of dementia with Lewy bodies |journal=Alzheimers Res Ther |volume=7 |issue=1 |page=45 |date=2015 |pmid=26029267 |pmc=4448151 |doi=10.1186/s13195-015-0128-z |type=Review}}
12. ^{{cite journal | vauthors = Arnaldi D, Antelmi E, St Louis EK, Postuma RB, Arnulf I | title = Idiopathic REM sleep behavior disorder and neurodegenerative risk: To tell or not to tell to the patient? How to minimize the risk? | journal = Sleep Med Rev | volume = 36 | pages = 82–95 | date = December 2017 | pmid = 28082168 | doi = 10.1016/j.smrv.2016.11.002 | type= Review }}
13. ^{{cite journal |vauthors=Walker Z, Possin KL, Boeve BF, Aarsland D |title=Lewy body dementias |journal=Lancet |volume=386 |issue=10004 |pages=1683–97 |date=October 2015 |pmid=26595642 |pmc=5792067 |doi=10.1016/S0140-6736(15)00462-6 |type=Review}}
14. ^{{cite journal |vauthors=Weil RS, Lashley TL, Bras J, Schrag AE, Schott JM |title=Current concepts and controversies in the pathogenesis of Parkinson's disease dementia and Dementia with Lewy Bodies |journal=F1000Res |volume=6 |issue= |pages=1604 |date=2017 |pmid=28928962 |pmc=5580419 |doi=10.12688/f1000research.11725.1 |type=Review}}
15. ^1 2 3 4 {{cite journal |vauthors=Taylor A, Yardley C |title=Advocacy, education, and the role of not-for-profit organizations in Lewy body dementias |journal=Alzheimers Res Ther |volume=6 |issue=5 |pages=59 |date=2014 |pmid=26082807 |pmc=4468791 |doi=10.1186/s13195-014-0059-0 |type=Review}}
16. ^{{cite web|title=Lewy body dementia: Hope through research |url= https://www.ninds.nih.gov/Disorders/Patient-Caregiver-Education/Hope-Through-Research/Lewy-Body-Dementia-Hope-Through-Research |website= National Institute of Neurological Disorders and Stroke |publisher = US National Institutes of Health |accessdate= April 6, 2018|date=December 8, 2017}}
17. ^{{cite journal |vauthors=Taylor A, Yardley C |title=Advocacy, education, and the role of not-for-profit organizations in Lewy body dementias |journal=Alzheimers Res Ther |volume=6 |issue=5 |pages=59 |date=2014 |pmid=26082807 |pmc=4468791 |doi=10.1186/s13195-014-0059-0 |type=Review}}
18. ^1 2 {{cite journal |vauthors=Sahlas DJ |title=Dementia with Lewy bodies and the neurobehavioral decline of Mervyn Peake |journal=Arch. Neurol. |volume=60 |issue=6 |pages=889–92 |date=June 2003 |pmid=12810496 |doi=10.1001/archneur.60.6.889 }}
19. ^1 {{Cite news|author= Gallman S |title = Robin Williams' widow speaks: Depression didn't kill my husband |url = http://www.cnn.com/2015/11/03/health/robin-williams-widow-susan-williams/index.html|work = CNN|accessdate = April 6, 2018 |deadurl = no|archiveurl = https://web.archive.org/web/20151104002632/http://www.cnn.com/2015/11/03/health/robin-williams-widow-susan-williams/index.html|archivedate = April 11, 2015 |date= November 4, 2015}}
20. ^1 {{cite journal |vauthors=Williams SS |title=The terrorist inside my husband's brain |journal=Neurology |volume=87 |issue=13 |pages=1308–11 |date=September 2016 |pmid=27672165 |doi=10.1212/WNL.0000000000003162 }}
21. ^{{cite news |url= https://www.scientificamerican.com/article/how-lewy-body-dementia-gripped-robin-williams1/ |title= How Lewy body dementia gripped Robin Williams |author= Robbins R |work= Scientific American |date= September 30, 2016 |accessdate= April 9, 2018}}
22. ^{{Cite news |url= https://theconversation.com/robin-williams-had-dementia-with-lewy-bodies-so-what-is-it-and-why-has-it-been-eclipsed-by-alzheimers-50221 |title= Robin Williams had dementia with Lewy bodies -- so, what is it and why has it been eclipsed by Alzheimer's? |author-link = Ian G. McKeith | last = McKeith | first = IG | name-list-format = vanc |newspaper= The Conversation |access-date= April 6, 2018 |deadurl=no|archiveurl=https://web.archive.org/web/20161104010452/https://theconversation.com/robin-williams-had-dementia-with-lewy-bodies-so-what-is-it-and-why-has-it-been-eclipsed-by-alzheimers-50221 |archivedate= April 11, 2016 }}
23. ^1 {{cite web |url=https://www.lbda.org/content/lbda-clarifies-autopsy-report-comedian-robin-williams |publisher= Lewy Body Dementia Association |title= LBDA Clarifies Autopsy Report on Comedian, Robin Williams |date= November 10, 2014 | accessdate = April 19, 2018}}
24. ^{{cite news |author=Carlson M |title=Obituary: Estelle Getty |url=https://www.theguardian.com/culture/2008/jul/24/television.television |accessdate=October 13, 2013 |newspaper=theguardian.com |date=July 24, 2008 |deadurl=no |archiveurl=https://web.archive.org/web/20130902115947/http://www.theguardian.com/culture/2008/jul/24/television.television |archivedate=September 2, 2013}}
25. ^{{cite news | url= http://www.latimes.com/news/obituaries/la-me-nicholas-king-20120423,0,3790852.story |author= McLellan D |date= April 23, 2012 |title= Nicholas King dies at 79; actor helped preserve the Watts Towers |work= The Los Angeles Times |accessdate= April 19, 2018}}
26. ^{{cite news |url=https://www.townandcountrymag.com/society/a9914626/dina-merrill-obituary/ |title=Actress and philanthropist Dina Merrill dies at 93 |accessdate=March 22, 2018 |work= Town and Country Magazine |date= May 23, 2017 |author= Dangremond S }}
27. ^{{Cite news | url=http://www.latimes.com/local/obituaries/la-me-0624-donald-featherstone-20150624-story.html | title= Don Featherstone dies at 79; creator of the plastic pink flamingo |author= Woo E |date= June 24, 2015 | accessdate= March 22, 2018 |work= Los Angeles Times}}
28. ^{{cite news |url=https://www.cnn.com/2014/06/20/health/casey-kasem-end-of-life-care/index.html | title= Casey Kasem and a lesson about end-of-life care |author= Caffrey J |publisher= CNN |date= April 18, 2016 | accessdate= March 22, 2018}}
29. ^{{cite news|author = Papineau P |url=https://www.ledevoir.com/culture/actualites-culturelles/474105/deces-de-pierre-lalonde| title = L'idole d'une génération s'éteint|publisher=Le Devoir|date=June 23, 2016|accessdate=April 9, 2018 |language= fr}}
30. ^{{cite web|url=http://www.journaldemontreal.com/2016/06/22/pierre-lalonde-souffrait-aussi-de-la-demence-de-corps-de-lewy/|title=Pierre Lalonde souffrait aussi de la démence à corps de Lewy|publisher= Le Journal de Montréal|accessdate=March 22, 2018 |author= Belanger C |language= fr |date= June 22, 2016}}
31. ^{{cite news |url= https://www.washingtonpost.com/wp-dyn/content/article/2008/12/26/AR2008122601714.html |title= Seymour Berry, 86; Headed U.S. Agency |date= December 27, 2008 |work= Washington Post |accessdate= April 19, 2018}}
32. ^{{cite news| author = Shaw D, Landsberg M| title = L.A. icon Otis Chandler dies at 78| work = The Los Angeles Times| date = February 27, 2006| url = http://www.latimes.com/news/local/la-me-chandler-obit,0,7195252.story?page=1&coll=la-home-headlines| accessdate = July 23, 2008| deadurl = no| archiveurl = https://web.archive.org/web/20070426114430/http://www.latimes.com/news/local/la-me-chandler-obit,0,7195252.story?page=1&coll=la-home-headlines| archivedate = April 26, 2007}}
33. ^{{cite news |url= http://chicago.suntimes.com/news/7/71/1288547/philip-rock-longest-serving-illinois-senate-president-dies |title= Philip Rock, ex-Senate leader known for mentoring and bipartisanship, dies |work= Chicago Sun-Times |date= January 29, 2016 |accessdate= April 19, 2018 | deadurl=yes |archiveurl=https://web.archive.org/web/20160201093023/http://chicago.suntimes.com/news/7/71/1288547/philip-rock-longest-serving-illinois-senate-president-dies |archivedate= February 1, 2016 }}
34. ^{{cite news |url= https://www.usatoday.com/story/life/people/2018/09/28/ted-turner-has-lewy-body-dementia-what-neurological-disorder/1456677002/ |author= Deerwester J |work= USA TODAY |date= September 28, 2018 |accessdate= September 30, 2018|title= Ted Turner has Lewy Body Dementia}}
35. ^{{cite news |author= O'Donnell M |title= Arnold R. Hirsch dies; analyzed Chicago segregation in influential book |url= https://chicago.suntimes.com/news/arnold-r-hirsch-dies-analyzed-chicago-segregation-in-influential-book/ |accessdate= April 19, 2018 |work= Chicago Sun Times |date= March 26, 2018}}
36. ^ {{cite news |title= Jessie Isabelle Price Dies On November 12 |url= http://www.27east.com/news/article.cfm/Quogue/131382/Jessie-Isabelle-Price-Dies-On-November-12 |accessdate= April 19, 2018 |work= The Southampton Press |date= November 23, 2015}}
37. ^{{cite news|author=Kuc C|title=For Stan Mikita, all the Blackhawks memories are gone|url=http://www.chicagotribune.com/sports/hockey/blackhawks/ct-stan-mikita-blackhawks-spt-0615-20150614-story.html#page=1|accessdate= March 22, 2018 |work= Chicago Tribune |date=June 15, 2015 |deadurl=no|archiveurl=https://web.archive.org/web/20150616044959/http://www.chicagotribune.com/sports/hockey/blackhawks/ct-stan-mikita-blackhawks-spt-0615-20150614-story.html#page=1|archivedate=June 16, 2015}}
38. ^{{cite news |author= Wood B| url= https://www.sltrib.com/news/health/2016/04/07/utah-doctor-diagnosing-parkinsons-lewy-body-dementia-has-improved-but-cure-remains-out-of-reach/ | title= Utah doctor: Diagnosing Parkinson’s, Lewy body dementia has improved, but cure remains out of reach | work= Salt Lake Tribune | date=April 6, 2016 | access-date=April 6, 2018}}
39. ^{{cite news |url= https://www.nytimes.com/2012/01/08/sports/baseball/andy-carey-third-baseman-for-1950s-yankees-dies-at-80.html |title= Andy Carey, Third Baseman for 1950s Yankees, Dies at 80 |accessdate= April 19, 2018 |author= Weber B |date= January 7, 2012}}
40. ^{{cite web |url= http://www.sleepeducation.org/news/2012/01/27/sleepwalk-with-me-comedian's-sleep-disorder-experience-comes-to-film |title= Sleepwalk with Me: Comedian's sleep disorder experience comes to film |publisher= American Academy of Sleep Medicine | date= January 26, 2012 |accessdate= April 22, 2018}}

External links

{{Medical resources
| DiseasesDB =
| ICD10 = {{ICD10|G31.8}}† {{ICD10|F02.8}}*
| ICD9 =
| ICDO =
| OMIM =
| MedlinePlus =
| eMedicineSubj =
| eMedicineTopic =
| MeshID =
}}{{Diseases of the nervous system}}{{DEFAULTSORT:Lewy Body dementias}}

1 : Lewy body dementia
随便看

　

开放百科全书收录14589846条英语、德语、日语等多语种百科知识，基本涵盖了大多数领域的百科知识，是一部内容自由、开放的电子版国际百科全书。

　

Copyright © 2023 OENC.NET All Rights Reserved
京ICP备2021023879号 更新时间：2024/9/25 12:25:55