“Methiodide”的意思、由来-开放百科全书

词条

Methiodide

释义

References

In organic chemistry, a methiodide is a chemical derivative produced by the reaction of a compound with methyl iodide. Methiodides may be formed through the methylation of amines:

R₃N + CH₃I → (CH₃)R₃N⁺I⁻

Methiodides are generally prepared to alter chemical or pharmacological properties. Examples include:

Cocaine methiodide, a charged cocaine analog which cannot pass the blood brain barrier and enter the brain^[1]
Bicuculline methiodide, a water-soluble form of bicuculline

References

1. ^{{cite journal | title = Potencies of Cocaine Methiodide on Major Cocaine Targets in Mice | vauthors = Hill ER, Tian J, Tilley MR, Zhu MX, Gu HH | journal = PLoS ONE | year = 2009 | volume = 4 | pmid = 19855831 | issue = 10 | pmc = 2762027 | pages = e7578 | doi = 10.1371/journal.pone.0007578 | url = http://www.plosone.org/article/info:doi%2F10.1371%2Fjournal.pone.0007578 | editor1-last = Manzoni | editor1-first = Olivier Jacques|bibcode = 2009PLoSO...4.7578H }}

1 : Quaternary ammonium compounds

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