| 词条 | Methuselah-like proteins |
| 释义 |
| Symbol = Methuselah_N | Name = Methuselah N-terminus | image = PDB 1fjr EBI.jpg | width = | caption = Structure of the ectodomain of Methuselah, a Drosophila G protein-coupled receptor associated with extended lifespan.[1] | Pfam = PF06652 | InterPro = IPR010596 | SMART = | PROSITE = | SCOP = 1fjr | TCDB = | OPM family = | OPM protein = | PDB = {{PDB2|1fjr}} }} The Methuselah-like proteins are a family of G protein-coupled receptors found in insects that play a role in aging and reproduction. Antagonizing these receptors can extend the life span of the animal and make it more resistant to free radicals and starvation, but also reduce reproduction and increase cold sensitivity. The age dependent decline in olfaction and motor function is unaffected.[2] Methuselah-like proteins are related to G protein-coupled receptors of the secretin receptor family.[1] References1. ^1 {{cite journal |vauthors=West AP, Llamas LL, Snow PM, Benzer S, Bjorkman PJ |title=Crystal structure of the ectodomain of Methuselah, a Drosophila G protein-coupled receptor associated with extended lifespan |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue=7 |pages=3744–9 |date=March 2001 |pmid=11274391 |pmc=31123 |doi=10.1073/pnas.051625298 |url=}} {{G protein-coupled receptors}}{{protein-stub}}2. ^{{cite journal |vauthors=Alic N, Partridge L | title = Antagonizing Methuselah to extend life span | journal = Genome Biology | volume = 8 | issue = 8 | pages = 222 | year = 2007 | pmid = 17764591 | pmc = 2374980 | doi = 10.1186/gb-2007-8-8-222 | url = }} 3 : G protein-coupled receptors|Life extension|Aging-related proteins |
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