| 释义 |
- References
- Further reading
{{Underlinked|date=March 2019}}{{Infobox_gene}}Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the MGAT1 gene.[1][2]{{PBB_Summary
| section_title =
| summary_text = There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis.[2]
}}References1. ^{{cite journal |vauthors=Hull E, Sarkar M, Spruijt MP, Hoppener JW, Dunn R, Schachter H | title = Organization and localization to chromosome 5 of the human UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I gene | journal = Biochem Biophys Res Commun | volume = 176 | issue = 2 | pages = 608–15 |date=Jun 1991 | pmid = 1827260 | pmc = | doi =10.1016/S0006-291X(05)80227-X }}
2. ^1 {{cite web | title = Entrez Gene: MGAT1 mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4245| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Kumar R, Yang J, Eddy RL, etal |title=Cloning and expression of the murine gene and chromosomal location of the human gene encoding N-acetylglucosaminyltransferase I |journal=Glycobiology |volume=2 |issue= 4 |pages= 383–93 |year= 1992 |pmid= 1421759 |doi=10.1093/glycob/2.4.383 }}
- {{cite journal |vauthors=Kumar R, Yang J, Larsen RD, Stanley P |title=Cloning and expression of N-acetylglucosaminyltransferase I, the medial Golgi transferase that initiates complex N-linked carbohydrate formation |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 24 |pages= 9948–52 |year= 1991 |pmid= 1702225 |doi=10.1073/pnas.87.24.9948 | pmc=55291 }}
- {{cite journal |vauthors=Tan J, D'Agostaro AF, Bendiak B, etal |title=The human UDP-N-acetylglucosamine: alpha-6-D-mannoside-beta-1,2- N-acetylglucosaminyltransferase II gene (MGAT2). Cloning of genomic DNA, localization to chromosome 14q21, expression in insect cells and purification of the recombinant protein |journal=Eur. J. Biochem. |volume=231 |issue= 2 |pages= 317–28 |year= 1995 |pmid= 7635144 |doi=10.1111/j.1432-1033.1995.tb20703.x }}
- {{cite journal |vauthors=Yip B, Chen SH, Mulder H, etal |title=Organization of the human beta-1,2-N-acetylglucosaminyltransferase I gene (MGAT1), which controls complex and hybrid N-glycan synthesis |journal=Biochem. J. |volume=321 |issue= 2|pages= 465–74 |year= 1997 |pmid= 9020882 |doi= | pmc=1218092 }}
- {{cite journal |vauthors=Yen CL, Stone SJ, Cases S, etal |title=Identification of a gene encoding MGAT1, a monoacylglycerol acyltransferase |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 13 |pages= 8512–7 |year= 2002 |pmid= 12077311 |doi= 10.1073/pnas.132274899 | pmc=124292 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
- {{cite journal |vauthors=Colland F, Jacq X, Trouplin V, etal |title=Functional proteomics mapping of a human signaling pathway |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 | pmc=442148 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
- {{cite journal |vauthors=Otsuki T, Ota T, Nishikawa T, etal |title=Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries |journal=DNA Res. |volume=12 |issue= 2 |pages= 117–26 |year= 2007 |pmid= 16303743 |doi= 10.1093/dnares/12.2.117 }}
- {{cite journal |vauthors=Saribas AS, Johnson K, Liu L, etal |title=Refolding of human beta-1-2 GlcNAc transferase (GnT1) and the role of its unpaired Cys 121 |journal=Biochem. Biophys. Res. Commun. |volume=362 |issue= 2 |pages= 381–6 |year= 2007 |pmid= 17716624 |doi= 10.1016/j.bbrc.2007.07.199 }}
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