| 释义 |
- References
- Further reading
{{Underlinked|date=March 2014}}{{Infobox_gene}}Beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the MGAT3 gene.[1][2]{{PBB_Summary
| section_title =
| summary_text = There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. The enzyme encoded by this gene transfers a GlcNAc residue to the beta-linked mannose of the trimannosyl core of N-linked oligosaccharides and produces a bisecting GlcNAc. Multiple alternatively spliced variants, encoding the same protein, have been identified.[2]
}}References1. ^{{cite journal |vauthors=Ihara Y, Nishikawa A, Tohma T, Soejima H, Niikawa N, Taniguchi N | title = cDNA cloning, expression, and chromosomal localization of human N-acetylglucosaminyltransferase III (GnT-III) | journal = J Biochem | volume = 113 | issue = 6 | pages = 692–8 |date=Oct 1993 | pmid = 8370666 | pmc = | doi = }}
2. ^1 {{cite web | title = Entrez Gene: MGAT3 mannosyl (beta-1,4-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4248| accessdate = }}
Further reading{{refbegin | 2}}- {{cite journal |vauthors=Kim YJ, Park JH, Kim KS, etal |title=Sequence analysis of the 5'-flanking region of the gene encoding human N-acetylglucosaminyltransferase III. |journal=Gene |volume=170 |issue= 2 |pages= 281–3 |year= 1996 |pmid= 8666260 |doi=10.1016/0378-1119(95)00818-7 }}
- {{cite journal |vauthors=Koyama N, Miyoshi E, Ihara Y, etal |title=Human N-acetylglucosaminyltransferase III gene is transcribed from multiple promoters. |journal=Eur. J. Biochem. |volume=238 |issue= 3 |pages= 853–61 |year= 1996 |pmid= 8706690 |doi=10.1111/j.1432-1033.1996.0853w.x }}
- {{cite journal |vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
- {{cite journal |vauthors=Dunham I, Shimizu N, Roe BA, etal |title=The DNA sequence of human chromosome 22. |journal=Nature |volume=402 |issue= 6761 |pages= 489–95 |year= 1999 |pmid= 10591208 |doi= 10.1038/990031 }}
- {{cite journal |vauthors=Ikeda Y, Koyota S, Ihara H, etal |title=Kinetic basis for the donor nucleotide-sugar specificity of beta1, 4-N-acetylglucosaminyltransferase III. |journal=J. Biochem. |volume=128 |issue= 4 |pages= 609–19 |year= 2000 |pmid= 11011143 |doi= 10.1093/oxfordjournals.jbchem.a022793}}
- {{cite journal |vauthors=Song EY, Kang SK, Lee YC, etal |title=Expression of bisecting N-acetylglucosaminyltransferase-III in human hepatocarcinoma tissues, fetal liver tissues, and hepatoma cell lines of Hep3B and HepG2. |journal=Cancer Invest. |volume=19 |issue= 8 |pages= 799–807 |year= 2002 |pmid= 11768033 |doi=10.1081/CNV-100107741 }}
- {{cite journal |vauthors=Shibukawa Y, Takahashi M, Laffont I, etal |title=Down-regulation of hydrogen peroxide-induced PKC delta activation in N-acetylglucosaminyltransferase III-transfected HeLaS3 cells. |journal=J. Biol. Chem. |volume=278 |issue= 5 |pages= 3197–203 |year= 2003 |pmid= 12427758 |doi= 10.1074/jbc.M207870200 }}
- {{cite journal |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
- {{cite journal |vauthors=Sasai K, Ikeda Y, Ihara H, etal |title=Caveolin-1 regulates the functional localization of N-acetylglucosaminyltransferase III within the golgi apparatus. |journal=J. Biol. Chem. |volume=278 |issue= 28 |pages= 25295–301 |year= 2003 |pmid= 12716887 |doi= 10.1074/jbc.M301913200 }}
- {{cite journal |vauthors=Millar JK, Christie S, Porteous DJ |title=Yeast two-hybrid screens implicate DISC1 in brain development and function. |journal=Biochem. Biophys. Res. Commun. |volume=311 |issue= 4 |pages= 1019–25 |year= 2004 |pmid= 14623284 |doi=10.1016/j.bbrc.2003.10.101 }}
- {{cite journal |vauthors=Isaji T, Gu J, Nishiuchi R, etal |title=Introduction of bisecting GlcNAc into integrin alpha5beta1 reduces ligand binding and down-regulates cell adhesion and cell migration. |journal=J. Biol. Chem. |volume=279 |issue= 19 |pages= 19747–54 |year= 2004 |pmid= 14998999 |doi= 10.1074/jbc.M311627200 }}
- {{cite journal |vauthors=Collins JE, Wright CL, Edwards CA, etal |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84 | pmc=545604 }}
- {{cite journal |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
- {{cite journal |vauthors=Kimura K, Wakamatsu A, Suzuki Y, etal |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 | pmc=1356129 }}
- {{cite journal |vauthors=Fiala M, Liu PT, Espinosa-Jeffrey A, etal |title=Innate immunity and transcription of MGAT-III and Toll-like receptors in Alzheimer's disease patients are improved by bisdemethoxycurcumin. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 31 |pages= 12849–54 |year= 2007 |pmid= 17652175 |doi= 10.1073/pnas.0701267104 | pmc=1937555 }}
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