The Middle East may refer to:

• Middle East, a historical and political region of Afro-Eurasia
• Greater Middle East, a new proposed political region
• Middle East Airlines, the flag carrier airline of Lebanon
• The Middle East (nightclub), a live music venue, bar, and restaurant in Cambridge, Massachusetts, USA
• Middle East, Baltimore, Maryland, United States, a neighborhood
• Middle East Television, a Christian television station
• The Middle East (band), an Australian Indie band from Townsville, Queensland
• The Middle East (magazine), a London-based magazine
• Mideast Youth, a Bahrain-based regional digital network
• Mid-East Region, Ireland, a region of the Republic of Ireland

• Two Creeks, WI
• Two Creeks, Wisconsin
• Two Days in the Valley
• Two-decker
• Two demons
• Two dimension
• Two-dimensional
• Two dimensional
• Two Dimensional Gel Electrophoresis
• Two-dimensional gel electrophoresis
• Two dimensional gel electrophoresis
• Two dimensions
• Two (disambiguation)
• Two dogmas of empiricism
• Two Dogmas of Empiricism
• Two dollar bill
• Two Dollar Coin (Canada)
• Two Dudes with Attitudes
• Two Eighty
• Two Eighty (web comic)
• Two-element Boolean algebra
• Two element boolean algebra
• Two Emperors
• Two-empire system
• Two English Girls